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  • Cell & Developmental Biology  (7)
  • oat  (6)
  • pharmacokinetics  (6)
  • 1
    ISSN: 1432-1041
    Keywords: prednisolone ; hydrocortisone ; cushingoid syndrome ; pharmacokinetics ; renal transplant ; oral disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To establish if the appearance of cushingoid side effects in patients taking exogenous glucocorticoids is related to the disposition and metabolism of these steroids and endogenous hydrocortisone, 15 stable renal transplant patients and 12 patients treated with prednisone for oral mucocutaneous vesiculo-erosive diseases were investigated. All 27 patients were given their usual prednisone dose orally on one occasion, and 24 were given the same amount of prednisolone intravenously on another occasion. Following dosing, plasma samples were obtained for determination of the areas under the plasma concentration time curves of total prednisolone, prednisone and hydrocortisone by high performance liquid chromatography, and of unbound prednisolone by equilibrium dialysis. The bioavailability of prednisone, the interconversion of prednisone into prednisolone, the clearance of total and unbound prednisolone, the prednisolone binding capacity of albumin and transcortin, and the affinity of albumin for prednisolone did not differ between the 14 patients without cushingoid side effects and the 13 cushingoid patients. Compared to those who had cushingoid features, patients who developed no side effects had a higher affinity constant for prednisolone binding to transcortin − 2.04±0.27 × 107 L/M vs. 1.34±0.16×107 (X±SE;P〈0.05), more frequently exhibited peak hydrocortisone levels within the normal range (6/14 vs 1/13), more often had measurable (〉10ng/ml) hydrocortisone in the plasma samples collected during the kinetic studies (123/291 vs 74/325;P〈0.001) and had higher areas under the plasma concentration time curve of hydrocortisone (median, range), i.e. 8081 ng/ml · min (0–21 637 ng/ml · min) vs 386 ng/ml · min (0–16 329 ng/ml · min;P〈0.005). The data suggest that endogenous hydrocortisone production is not as suppressed in patients with visible cushingoid signs as in noncushingoid patients, and that there is no significant difference in the pharmacokinetics of exogenous glucocorticoids between patients with and without cushingoid side effects.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 26 (1984), S. 505-511 
    ISSN: 1432-1041
    Keywords: prednisolone ; prednisone ; oral contraceptives ; 6β-hydroxylase ; transcortin ; protein-binding ; steroid metabolism ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The oestrogenic component of oral contraceptives affects the activity of liver enzymes and the concentrations of plasma proteins implicated in steroid metabolism and transport. The present study was designed to determine these effects on the kinetics of prednisone and prednisolone. After an oral dose of prednisone, women on oral contraceptive steroids (n=10) had higher mean (±SD) area under the plasma concentration versus time curves of total (428±67 µg/ml/min vs 188±28 µg/ml/min, p〈0.001) and unbound prednisolone (64±10 µg/ml/min vs 41±10 µg/ml/min, p〈0.001) than women not taking oral contraceptive steroids (n=10). The differences were attributable to a lower non-renal clearance of prednisolone and to a higher apparent systemic availability of the drug in contraceptive users than in the controls. The affinity of albumin and transcortin for prednisolone was lower in women on oral contraceptives than in controls (p〈0.001). Thus, altered kinetics and protein binding may account for the known increase in glucocorticoid efficacy by oestrogens.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 19 (1981), S. 209-212 
    ISSN: 1432-1041
    Keywords: prednisone ; prednisolone ; azathioprine ; 11 β-hydroxydehydrogenase ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clinical and pharmacokinetic observations suggest that azathioprine may diminish the plasma level of prednisolone. To study the extent of this possible interaction, and to define the underlying mechanism, total and unbound prednisolone and total prednisone concentrations were assessed in 11 subjects following an oral dose of prednisone once with and once without concomitant oral administration of azathioprine. Azathioprine did not affect the area under the plasma concentration-time curve of total and unbound prednisolone; furthermore, the interconversion of prednisone into prednisolone was not influenced by azathioprine.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: cefoperazone ; peritoneal dialysis ; pharmacokinetics ; terminal renal failure ; peritonitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65±0.4 h, the total clearance amounting to 70.1±19.2 ml/min. Peritoneal clearance was calculated to be 6.9±1 ml/min. After peritoneal instillation, the bioavailability was 63.9±5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 389-393 
    ISSN: 1432-1041
    Keywords: ornidazole ; haemodialysis ; pharmacokinetics ; renal function ; metabolism ; urine concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of ornidazole was studied in 6 patients treated by haemodialysis and in 8 subjects with a creatinine clearance between 4 and 99 ml/min × 1.73 m2. Blood and urine collections were performed for 72 h after i.v. and oral administration of 1.0 g ornidazole. Total body clearance, half-life, volume of distribution and systemic availability were independent of renal function and did not differ from previously reported values in normal volunteers. The haemodialysis clearance of ornidazole was 〉100% higher than the total body clearance. The renal clearance of ornidazole accounted for less than 7% of the total body clearance. The percentage of the dose of ornidazole recovered in urine as parent compound or as the biologically active metabolites [α-(chloromethyl)-2 hydroxymethyl-5 nitroimidazole-1 ethanol and 3-(2 methyl-5 nitroimidazole-1-yl)1,2 propanediol] decreased linearly with decreasing renal function. Although the sum of those three compounds recovered in urine accounted for less than 10% of the total dose of ornidazole administered, they yielded therapeutic concentrations (〉4 µg/ml) in urine over 24 h after dosing. Due to the peculiar pharmacokinetic behaviour of ornidazole, i.e. high haemodialysis clearance in the absence of significant renal clearance, no dosage adjustment is necessary while renal function declines, but an increased dose is mandatory while patients are on dialysis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 29 (1986), S. 697-701 
    ISSN: 1432-1041
    Keywords: tenoxicam ; renal insufficiency ; non-steroidal antiinflammatory agents ; protein binding ; metabolism ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of tenoxicam after a single oral dose of 20 mg has been studied in 12 patients with various degrees of decreased renal function. Unchanged tenoxicam and its 5′OH-metabolite in plasma and urine were determined by HPLC. The mean areas under the plasma concentration-time curve (138±53 µg/ml·h) and terminal half-lives in patients with impaired renal function did not differ from values previously reported in normal volunteers, nor did the peak concentration of tenoxicam. The half-life of 5′OH-tenoxicam and unchanged tenoxicam where the same. The urinary excretion of 5′OH-tenoxicam fell with decreasing renal function. Thus no dosage adjustment should be necessary and the usual daily dose of tenoxicam may be administered once daily also to patients with renal failure.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Euphytica 54 (1991), S. 221-229 
    ISSN: 1573-5060
    Keywords: Avena sativa L. ; groat-oil content ; growth analysis ; oat ; phenotypic recurrent selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A considerable increase in groat-oil content of oat (Avena sativa L.) has been accomplished recently. The objective of this study was to determine whether physiological traits of oat plants with high groat-oil content are changed in a way that would provide the energy needed for increased groat-oil content. Growth analyses were conducted in 1987 and 1988 on 25 oat lines with low and on 25 with high groat-oil content. Three harvests were made in 1987 and six in 1988. Plot biomass, plant weight, leaf area, and leaf weight were measured at each harvest and estimates for relative crop growth rate, unit leaf area, leaf area ratio, specific leaf area, and leaf weight ratio were derived. Grain yield, groat-oil content, and groat-protein content were measured at maturity. The data were analysed by using the stepwise multivariate analysis of variance technique. The results suggest that changes in growth characteristics and increases in photosynthetic capacity provide the extra bioenergy required for synthesis of more groat oil. The groat-protein content did not change as a result of increased groat-oil content in oat.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Euphytica 70 (1993), S. 141-150 
    ISSN: 1573-5060
    Keywords: Avena sativa ; grain yield ; straw yield ; test weight ; groat percent ; heading date ; oat ; protein yield
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Three S1-recurrent selection programs (designated HG, HP, and HGP) for increasing protein yield of oat (Avena sativa L.) were conducted for five cycles of selection. The selection criteria in each program (line of descent) emphasized different components of protein yield; high grain yield in HG, both high protein concentration of the groats (caryopsis) and high grain yield in HP, and high protein yield per se in HGP. Heading date and height were restricted to no net change. The objectives of this study were to evaluate the agronomic performance of these three lines of descent and the correlated responses in agronomic traits due to selection. Thirty to sixty random S0-derived lines from each cycle and ten check lines were grown in hill-plot experiments at two locations in 1989. Grain yield increased in all three lines of descent; HG showed the greatest rate of gain followed by HGP and then HP (0.20, 0.10, and 0.07 Mg ha-1 per cycle, respectively). Test weight decreased in HGP by 2.6 kg m-3 per cycle and in HP by 4.0 kg m-3 per cycle, but remained constant in HG. Cycle 5 (C5) means for straw yield, height, and seed weight were not significantly different from the C0 means for any line of descent. Groat percent remained unchanged in HGP, increased from 70.1 to 71.7% in HG, and decreased from 69.9 to 67.6% in HP. Heading date decreased by 3 d in HG and HGP, but remained unchanged in HP. HG compares most favorably with commercial cultivars because of its high yield and acceptable agronomic traits, while HP tends to be low in test weight, seed weight, and groat percent.
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  • 9
    ISSN: 1573-5060
    Keywords: oat ; protein yield ; groat yield ; protein concentration ; recurrent selection ; Avena sativa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The objectives of this study were to evaluate the efficacy of S1-recurrent selection for increasing groat (caryopsis)-protein yield in oat (Avena sativa L.) and to compare the effects of three selection strategies on correlated responses in groat yield and groat-protein concentration. Three S1-recurrent selection programs were conducted for five cycles. Selection criteria in each program (line of descent) emphasized different components of protein yield; high grain yield in HG, both high grain yield and high groat-protein concentration in HP, and protein yield per se in HGP. Thirty to sixty random S0-derived lines from each cycle and ten check lines were evaluated in one year at two locations to estimate the response to selection. Groat-protein yield increased 4.4% cycle-1 in HG, 3.4% cycle-1 in HP, and 2.2% cycle-1 in HGP. Gains in groat yield were 7% cycle-1 in HG, 1% cycle-1 in HP, and 3% cycle-1 in HGP. Mean groat-protein yield and groat yield in the cycle 5 (C5) populations of all three lines of descent were equal to or slightly higher than those of high yielding cultivars. The HG line of descent showed a significant decrease from 193 to 175 g kg-1 groat protein, while the HP line of descent showed a significant increase from 202 to 218 g kg-1. The HGP line of descent showed a small but significant decline in groat protein from 200 to 192 g kg-1. In comparison, the high-protein commercial cultivars contained about 210 g kg-1 groat protein. The C5 population of the HP line of descent had a unique combination of high groat yield and high groat-protein concentration. Genotypic variances for groat-protein yield, groat yield, and groat-protein concentration were not always significant in the various cycles of the three lines of descent, but in no instance was there a consistent change from C0 to C5. S1-recurrent selection was effective for increasing groat-protein yield of oat, and with the proper germplasm and selection strategy both groat yield and groat-protein concentration can be improved simultaneously.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-5060
    Keywords: Avena stativa ; oat ; genetic correlation ; genotype × environment interaction ; heat stress ; N-deficiency ; P-deficiency ; components of variance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary In breeding crop varieties for stress environments, it must be decided whether to select directly, in the presence of stress, or indirectly, in a nonstress environment. The relative effectiveness of these two strategies depends upon the genetic correlation (r g ) between yield in stress and nonstress environments and upon heritability in each. These parameters were estimated for grain yield of 116 random oat lines grown in nonstress, P-deficient, N-deficient, and late-planted environments. Estimates of r g between yield in nonstress and yield in P-deficient, N-deficient, and late-planted environments were 0.52±0.24, 1.08±0.16, and 0.06±0.24, respectively. No consistent relationship between heritability and environment mean yield was observed. Direct selection in the presence of stress was predicted to be superior for yield in low-P and late-planted environments, but indirect selection in high-N environments was predicted to be as effective as direct selection in producing yield gain in low-N environments. These results confirm that neither high-yield environments nor environments in which the heritability of yield is maximized are necessarily optimum when the goal is to maximize yield gain in stress environments.
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