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  • 1
    Electronic Resource
    Electronic Resource
    Transcortinkonzentrationen im Plasma von Normalpersonen und Patienten mit Nieren- oder Lebererkrankungen (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 936-938 
    Details
    ISSN: 1432-1440
    Keywords: Transcortin ; Kidney disease ; Liver cirrhosis ; Estrogens ; Electroimmunodiffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the study was to assess the influence of chronic kidney and liver diseases on the transcortin concentrations in plasma. The mean (±SD) plasma concentration of transcortin was 45.0±6.7 mg/l in women not taking oral contraceptive steroids and 41.2±6.7 mg/l in healthy male volunteers. Patients with the nephrotic syndrome had low transcortin concentrations (females: 20.9±8.5 mg/l; males: 26.0±6.0 mg/l). Abnormally low concentrations were measured in females treated for endstage renal disease with chronic ambulant peritoneal dialysis (CAPD) (30.8±7.5 mg/l). Patients on hemodialysis or with a functioning renal allograft had normal transcortin concentrations in plasma. Females suffering from a primary biliary cirrhosis had normal transcortin concentrations and male patients with an alcoholic cirrhosis had abnormally low mean transcortin concentrations in plasma (32.6±7.4 mg/l). The transcortin concentrations in patients with a Gilbert syndrome were normal. Among patients with a kidney or liver disease, the large variability of the transcortin concentration in plasma indicates that the knowledge of the transcortin concentration or the unbound steroid concentration in plasma is mandatory for the interpretation of total glucocorticoid concentrations in plasma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727449
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  • 2
    Electronic Resource
    Electronic Resource
    Pulsus paradoxus indicating heart failure in paroxysmal supraventricular tachycardia: easy detection by pulse oximetry (1999)
    Springer
    Intensive care medicine 25 (1999), S. 333-334 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050848
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  • 3
    Electronic Resource
    Electronic Resource
    MES [2-(N-morpholine)-ethane sulphonic acid] buffer promotes the growth of external hyphae of the arbuscular mycorrhizal fungus Glomus intraradices in an alkaline sand (1997)
    Springer
    Biology and fertility of soils 25 (1997), S. 79-81 
    Details
    ISSN: 1432-0789
    Keywords: Key words Arbuscular mycorrhizal fungi ; External hyphae ; Glomus intraradices ; MES [2-(N-morpholino)-ethane sulphonic acid] ; Trifolium pratense ; Sulphur stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract In this work we investigated the hypothesis, suggested by unpublished experiments carried out previously, that application of MES [2-(N-morpholino)-ethane sulphonic acid] buffer to the substrate of plants hosting the arbuscular mycorrhizal fungus Glomus intraradices might favour the growth of external hyphae. The substrate of Trifolium pratense plants, with or without G. intraradices inoculum, was treated twice weekly, between weeks 5 and 11 of growth, plant with distilled water, P-supplemented 10% Hewitt nutrient solution (H+P), 51mM in H+P or 1mM TRIS-HCl in H+P. MES buffer increased the length of external G. intraradices hyphae and the density of propagules in the substrate, but plant growth was not affected. Although both TRIS-HCl and MES caused substrate pH to fall (from 8.51 to 7.35 and 7.17, respectively), only MES induced a significant increase in external hypha length. We conclude that the effect of MES on external hypha length was not due to plant growth or to substrate pH per se.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003740050284
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  • 4
    Electronic Resource
    Electronic Resource
    Familial isolated pulmonary hypoplasia: a case report, suggesting autosomal recessive inheritance (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 460-463 
    Details
    ISSN: 1432-1076
    Keywords: Key words     Pulmonary hypoplasia ; Familial ; Newborn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      The exceptional observation of a healthy couple with two girls and a boy suffering from pulmonary hypoplasia and two normal children is reported. The affected infants died 1, 2 and 20 h after birth respectively. No other malformations were found. Histological findings suggest that the underdevelopment of the lungs has its origin at a more proximal level than the terminal bronchioles. Autosomal recessive inheritance is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983413
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  • 5
    Electronic Resource
    Electronic Resource
    Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding (1990)
    Springer
    European journal of pediatrics 150 (1990), S. 136-138 
    Details
    ISSN: 1432-1076
    Keywords: Carbamazepine ; Hepatitis-toxic ; Neonate ; Pregnancy ; Breast-feeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a 3-week-old boy with cholestatic hepatitis, most likely due to carbamazepine exposure during pregnancy and breastfeeding. Cholestasis resolved after cessation of nursing. Liver function test results and histological findings were compatible with a drug-induced hepatitis. Other causes were excluded. While carbamazepine-induced hepatitis is well known in children and adults, it has never been described in association with prenatal exposure and/or breast-feeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072057
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  • 6
    Electronic Resource
    Electronic Resource
    Toxic methaemoglobin concentrations in premature infants after application of a prilocaine-containing cream and peridural prilocaine (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 785-788 
    Details
    ISSN: 1432-1076
    Keywords: Key words Premature infant ; Methaemoglobinaemia ; Prilocaine ; Caudal anaesthesia critical incident
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a retrospective analysis of eight episodes of toxic methaemoglobinaemia in seven premature infants after the combined exposure to prilocaine by EMLA cream (12.5 mg prilocaine) and caudal anaesthesia (5.4–6.7 mg/kg prilocaine). The causative relationship between prilocaine and the infants' deterioration came to our attention through an anonymous voluntary incident-reporting system. The highest methaemoglobin concentration found was 30.6% (5.5 h after anaesthesia). All infants were symptomatic (mottled skin, paleness, cyanosis, poor peripheral perfusion) and two were exposed to unnecessary diagnostic and therapeutic procedures for unspecified deterioration in their conditions. Pharmacokinetic evaluation indicated a single compartment first-order elimination with a methaemoglobin half-life of 8 h. Normal levels (〈1%) were reached 36 h after exposure to prilocaine. Conclusion Whereas local skin application of prilocaine to premature babies is safe, peridural administration is not because premature infants are more sensitive to methaemoglobin inducing agents and tolerate methaemoglobinaemia less well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051204
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  • 7
    Electronic Resource
    Electronic Resource
    A single dose of azathioprine does not affect the pharmacokinetics of prednisolone following oral prednisone (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 209-212 
    Details
    ISSN: 1432-1041
    Keywords: prednisone ; prednisolone ; azathioprine ; 11 β-hydroxydehydrogenase ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clinical and pharmacokinetic observations suggest that azathioprine may diminish the plasma level of prednisolone. To study the extent of this possible interaction, and to define the underlying mechanism, total and unbound prednisolone and total prednisone concentrations were assessed in 11 subjects following an oral dose of prednisone once with and once without concomitant oral administration of azathioprine. Azathioprine did not affect the area under the plasma concentration-time curve of total and unbound prednisolone; furthermore, the interconversion of prednisone into prednisolone was not influenced by azathioprine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561951
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: Clinical and pathophysiological implications (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 609-612 
    Details
    ISSN: 1432-1041
    Keywords: cefoperazone ; peritoneal dialysis ; pharmacokinetics ; terminal renal failure ; peritonitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65±0.4 h, the total clearance amounting to 70.1±19.2 ml/min. Peritoneal clearance was calculated to be 6.9±1 ml/min. After peritoneal instillation, the bioavailability was 63.9±5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543494
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  • 9
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients (1981)
    Springer
    European journal of clinical pharmacology 21 (1981), S. 235-242 
    Details
    ISSN: 1432-1041
    Keywords: prednisolone ; hydrocortisone ; cushingoid syndrome ; pharmacokinetics ; renal transplant ; oral disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To establish if the appearance of cushingoid side effects in patients taking exogenous glucocorticoids is related to the disposition and metabolism of these steroids and endogenous hydrocortisone, 15 stable renal transplant patients and 12 patients treated with prednisone for oral mucocutaneous vesiculo-erosive diseases were investigated. All 27 patients were given their usual prednisone dose orally on one occasion, and 24 were given the same amount of prednisolone intravenously on another occasion. Following dosing, plasma samples were obtained for determination of the areas under the plasma concentration time curves of total prednisolone, prednisone and hydrocortisone by high performance liquid chromatography, and of unbound prednisolone by equilibrium dialysis. The bioavailability of prednisone, the interconversion of prednisone into prednisolone, the clearance of total and unbound prednisolone, the prednisolone binding capacity of albumin and transcortin, and the affinity of albumin for prednisolone did not differ between the 14 patients without cushingoid side effects and the 13 cushingoid patients. Compared to those who had cushingoid features, patients who developed no side effects had a higher affinity constant for prednisolone binding to transcortin − 2.04±0.27 × 107 L/M vs. 1.34±0.16×107 (X±SE;P〈0.05), more frequently exhibited peak hydrocortisone levels within the normal range (6/14 vs 1/13), more often had measurable (〉10ng/ml) hydrocortisone in the plasma samples collected during the kinetic studies (123/291 vs 74/325;P〈0.001) and had higher areas under the plasma concentration time curve of hydrocortisone (median, range), i.e. 8081 ng/ml · min (0–21 637 ng/ml · min) vs 386 ng/ml · min (0–16 329 ng/ml · min;P〈0.005). The data suggest that endogenous hydrocortisone production is not as suppressed in patients with visible cushingoid signs as in noncushingoid patients, and that there is no significant difference in the pharmacokinetics of exogenous glucocorticoids between patients with and without cushingoid side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00627926
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  • 10
    Electronic Resource
    Electronic Resource
    Familial isolated pulmonary hypoplasia: a case report, suggesting autosomal recessive inheritance (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 460-463 
    Details
    ISSN: 1432-1076
    Keywords: Pulmonary hypoplasia ; Familial ; Newborn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The exceptional observation of a healthy couple with two girls and a boy suffering from pulmonary hypoplasia and two normal children is reported. The affected infants died 1, 2 and 20 h after birth respectively. No other malformations were found. Histological findings suggest that the underdevelopment of the lungs has its origin at a more proximal level than the terminal bronchioles. Autosomal recessive inheritance is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983413
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