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  • 1
    Electronic Resource
    Electronic Resource
    Die Induktion von Hirn- und Rückenmarktumoren bei Kaninchen mit N-Methyl-N-nitrosoharnstoff (1969)
    Springer
    Clinical and experimental medicine 150 (1969), S. 76-86 
    Details
    ISSN: 1591-9528
    Keywords: Brain neoplasms ; Neoplasms, experimental chemically induced ; Neoplasms, nervous tissue ; Nitroso compounds ; Rabbits ; Hirntumoren ; Chemisch induzierte experimentelle Tumoren ; Tumoren des Nervengewebes ; Nitrosoverbindungen ; Kaninchen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In 48 auswertbaren Versuchen sind nach intravenöser Injektion von Methylnitrosoharnstoff bei 33 Kaninchen (68,8%) Hirntumoren und in 4 Fällen gleichzeitig Rückenmarktumoren entstanden. Histologisch handelt es sich vorwiegend um multiforme Glioblastome und um Sarkome. Geschwülste der Nervenwurzeln und peripheren Nerven wurden im Gegensatz zu Ratten nicht gefunden. Weitere Unterschiede in der Lokalisation der induzierten Tumoren nach Methylnitrosoharnstoff-Applikation gegenüber Ratten bestehen bei Kaninchen in dem häufigen Auftreten von Dünndarmcarcinomen und multiplen Gefäßwandsarkomen verschiedener Organe. Kaninchen sind bisher die größte Tierart, bei der mit Methylnitrosoharnstoff die Erzeugung von Hirntumoren gelungen ist. Die intravenöse Injektion von Methylnitrosoharnstoff erweist sich zur Zeit als die beste Methode zur Induktion von Geschwülsten des Zentralnervensystems bei ausgewachsenen Kaninchen.
    Notes: Summary After intravenous injection of methylnitrosourea among 48 rabbits in 33 (68.8%) brain tumors were found and in 4 of these cases spinal cord tumors simultaneously. Histologically these neoplasms were glioblastomas and sarcomas mainly. Contrary to rats tumors of nerve roots and of peripheral nerves were not observed. Unlike in rats the induced tumors frequently occured as small intestine carcinomas and as multiple vessel wall sarcomas of different organs. Rabbits are the largest animal species in which of brain tumors were successfully induced by methylnitrosourea. The intravenous injection of methylnitrosourea is the best method for induction of neoplasms of the central nervous system in adult rabbits at this time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02045841
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia (2000)
    Springer
    Neurosurgical review 23 (2000), S. 145-150 
    Details
    ISSN: 1437-2320
    Keywords: Key words Focal cerebral ischemia ; Programmed neuronal death ; Nimodipine ; Mannitol ; Cerebroprotection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present study was conducted to evaluate the effects of nimodipine and mannitol on infarct size and on the amount of apoptosis after transient focal cerebral ischemia. Focal cerebral ischemia was induced in male Sprague-Dawley rats (weight 300–380 g) by transient occlusion of the right middle cerebral artery (MCAO) using an intraluminal thread model. All animals underwent ischemia for 2 h, followed by 24 h of reperfusion. Group I (n=16) was untreated. Group II (n=16) received 15% mannitol (1 g/kg as bolus) and group III (n=9) received 15 µg/kg/h nimodipine intravenously beginning 15 min prior to MCAO. Twenty-four hours after reperfusion, the brain was taken and sectioned in coronal slices. The slices were stained with H&E and with the transferase dUTP nick-end labeling (TUNEL) technique. Histopathological analysis revealed a significant (P〈0.05) decrease in infarct size in the striatum with both drugs: mannitol (group II) 25.4±5.9% and nimodipine (group III) 21.5±11.0% versus control (group I) 34.9±7.0% and in the cortex 2.7±2.0% (group II) and 6.3±2.4% (group III) versus control 14.4±9.0% (group I). The number of apoptotic cells was statistically lower in the therapy groups (group III 9.6, group II 25.8) versus control (group I 57.9) (Mann-Whitney-Wilcoxon U-test Z〉1.96, P〈0.05). This study indicates that mannitol and nimodipine provide neuroprotection by preventing both the necrotic and apoptotic components of cell death after transient focal cerebral ischemia and may be effective as neuroprotective drugs for cerebrovascular surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00011946
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    Paper (German National Licenses)
    Fulltext
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