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  • Chemistry  (9)
  • Polymer and Materials Science  (5)
  • Clonidine  (3)
  • Osteologie  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 67 (1970), S. 170-174 
    ISSN: 1437-1596
    Keywords: Identifikationsmerkmale ; Osteologie ; Processus mastoideus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung An 105 Individuen, 61 männlichen und 44 weiblichen, wird die Behauptung eines Geschlechtsdimorphismus hinsichtlich der Höhe und Größe der Processus mastoidei statistisch nachgeprüft. Für die mediale und laterale Fortsatzhöhe lassen sich keine signifikanten Mittelwertsdifferenzen aufzeigen. Zudem ist die Varianz der Kollektive so groß, daß der Proc. mastoid. als Identifikationsmerkmal ausscheidet. Die gefundene Mittelwertsdifferenz der Größe der Fortsätze, hier durch die äußere Fläche ausgedrückt, läßt sich statistisch eindeutig sichern. Dies entspräche der Vorstellung einer Kausalbeziehung zwischen Ausbildung und Insertion der seitlichen Halsmuskulatur einerseits und Größe bzw. Volumen der Fortsätze andererseits.
    Notes: Summary The supposition regarding sex-linked differences in height and surface area of the mastoid process was tested in 105 human skulls, 61 of which were male and 44 were female. There was no statistically significant difference noted in the mean values of the lateral and medial measurements of the processes from both sexes. Some significance, however, was noted in the measurement of the surface area. This may be associated with the insertion of stronger lateral neck-musculature, as is isually the case in males.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 67 (1970), S. 175-183 
    ISSN: 1437-1596
    Keywords: Osteologie ; Identifikation ; Pneumatisation Warzenfortsatz ; Altersbestimmung ; Geschlechtsbestimmung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Pneumatisation von 91 Warzenfortsätzen erwachsener Menschen wird mittels Röntgendensitometrie in bezug auf Alters-, Geschlechts-, Seiten- und Volumen-abhängigkeit untersucht. Dabei läßt sich nur eine geringe Abhängigkeit (10%) vom Volumen des Proc. mastoid. feststellen. In der Literatur wird ein Zusammenwirken multipler Faktoren bei der Pneumatisation des Warzenfortsatzes angenommen, wobei die Größe des Muskelhöckers von funktionellen, hormonellen und hereditären Faktoren beeinflußt werden soll. Zum Teil wird auch die Meinung vertreten, daß sein mechanisch entlasteter Innenraum je nach der „Kraft der Schleimhaut“ entweder von dieser oder von spongiösem Knochen in der Art einer „Verdrängungsreaktion“ ausgefüllt wird. Als Merkmal zur Individualidentifikation ist die Pneumatisation des Mastoides aufgrund unterschiedlicher, individualspezifischer Ausformung der Cellulae durchaus geeignet; eine Alters- und Geschlechtsidentifikation unbekannter Einzelstücke ist jedoch nicht möglich.
    Notes: Summary X-ray densitometry of 91 adult mastoid processes and their relationships to sex and age as well as to the volume of the processes was carried out. No relationship to age or sex could be determined, however, a small correlation with the volume (10%) was ascertained. The pneumatization of the mastoid process supposedly depends on multiple factors, particularly functional, hormonal and hereditary. Some, however, believe that mucous membrane or spongious bone occupy the inner spaces of the process, depending on a mutual “displacement reaction”. The mastoid process is suitable for individual identification on the basis of the specific structure of its air spaces. Age and sex determination is impossible using unknown single specimens.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 314 (1980), S. 83-87 
    ISSN: 1432-1912
    Keywords: Guinea-pig ileum ; Presynaptic α-adrenoceptors ; Clonidine ; Morphine ; α-Adrenoceptor blocking agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to further characterize the α-adrenoceptors located on parasympathetic fibres. Segments of guinea-pig ileum were stimulated by transmural electrical pulses, and the ensuing contractions, which are due to the release of acetylcholine from postganglionic parasympathetic fibres, were monitored. Clonidine and tramazoline, which are thought to act preferentially on presynaptic α-adrenoceptors, reduced the contractions, whereas phenylephrine and methoxamine, postsynaptic α-adrenoceptor agonists, were ineffective. Contractions induced by acetylcholine were not changed by clonidine but were abolished by atropine. Yohimbine, piperoxan, phentolamine and thymoxamine reversed or prevented the inhibitory effect of clonidine. Prazosin and AR-C239 did not antagonize this effect. The inhibitory effect of tramazoline was antagonized by piperoxan but not by AR-C239 or by prazosin. Naloxone did not alter the action of clonidine, and piperoxan did not change the inhibitory effect of morphine. In conclusion, these experiments suggest the presence on cholinergic postganglionic fibres of both opiate receptors and α-adrenoceptors. The latter appear to resemble more closely α1-adrenoceptors than α1-adrenoceptors.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 12 (1977), S. 319-322 
    ISSN: 1432-1041
    Keywords: Clonidine ; Yohimbine ; sleep ; REM sleep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clonidine (300 µg orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an α sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 318 (1982), S. 288-294 
    ISSN: 1432-1912
    Keywords: Mianserin ; Clonidine ; Desipramine ; Acetylcholine ; α2-Adrenoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to characterize the effects of mianserin at α2-adrenoceptors. Firstly, the action of mianserin on postganglionic sympathetic fibres has been studied using the tachycardia induced by stimulation of the cardiac nerve in dogs. Mianserin increased this tachycardia, but could not prevent the inhibitory effect of clonidine in this model. However, an antagonistic effect of mianserin against clonidine was observed when animals were pretreated with desipramine. Secondly, mianserin antagonized the inhibitory effect of clonidine on the electrically stimulated guinea-pig ileum. In high concentrations, mianserin reduced both electrically and acetylcholine induced contractions. Thirdly, mianserin antagonised the sleep induced by clonidine in chickens. These results are consistent with α2-adrenoceptor blocking properties of mianserin in peripheral noradrenergic fibres in dogs, in cholinergic fibres in guinea-pig ileum and in the central nervous system in chickens.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Boc-L-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Phl (Boc = t-butyloxycarbonyl, Aib = α-aminoisobutyric acid, Bzl = benzyl, Phl = phenylalaninol), C59H90N10O14, the protected C-terminal nonapeptide with the sequence 12-20 of alamethicin, crystallizes in the orthorhombic space group P212121 with a = 15.666, b = 16.192, c = 26.876 Å, and Z = 4. The molecular conformation is right-handed helical with three α-(5 → 1 hydrogen bonds) and three β-turns (4 → 1 hydrogen bonds). All but two of the hydrogen bonds are significantly longer than the usual value and show bifurcation to some extent. The α/310r-helical nonapeptide molecules are arranged head-to-tail along the a direction. The resulting linear antiparallel chains are linked by a weak intermolecular hydrogen bridge, thus forming a two-dimensional layer structure in the ab plane. The conformation of this nonapeptide is almost identical with that of the corresponding C-terminal part found by x-ray crystallography of the eicosapeptide alamethicin.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 24 (1985), S. 961-978 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The x-ray structure of Boc-L-Ala-Aib-Ala-Aib-Ala-Glu(OBzl)-Ala-Aib-Ala-Aib-Ala-OMe(I) represents the first α-helix determined by direct methods. This undecapeptide is a model of the N-terminus of alamethicin, and it exhibits voltage-dependent pores in bilayer membranes at a higher voltage and concentration than alamethicin. The molecule crystallizes in the monoclinic space group P21 with a = 10.602(1), b = 23.884(3), c = 13.622(1) Å, β = 95.61(6)°, and Z = 2. It adopts a right-handed α-helical conformation in the solid state with intramolecular 5 → 1 hydrogen bonds. An additional intramolecular hydrogen bond is bifurcated, forming a stronger 4 → 1 interaction (i.e., a β-turn III) and a weaker 5 → 1 interaction, thus prolonging the α-helical part up to 9 residues. The α-helix radius of 2.1 Å, the height per residue (distance Ni … Ni + 4) of 1.53 Å, the resulting length of the α-helical part of 13.8 Å (9 residues) resp. 15.3 Å (10 residues), the van der Waals radius (4.7 Å), and the minimal diameter of pores formed by aggregation of 3-10 α-helices were calculated omitting the Glu(OBzl) side chain. In the crystal, the α-helices are linked head to tail via two hydrogen bridges forming continuous chains. Adjacent helices are oriented in antiparallel with their helix axes and have only van der Waals contacts.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 22 (1983), S. 241-246 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 13C-, 1H-nmr, CD, and x-ray crystallography revealed β-turns of type III for Boc-Gly-L-Ala-Aib-OMe, Boc-L-Ala-Aib-L-Ala-OMe; the 310-helix for Boc-Aib-L-Ala-Aib-L-Ala-Aib-OMe; and antiparallel arranged α-helices for Boc-L-Ala-Aib-Ala-Aib-Ala-Glu(OBzl)-Ala-Aib-Ala-Aib-Ala-OMe. An N-terminal rigid α-helical segment is found in the polypeptide antibiotics alamethicin, suzukacillin, and trichotoxin. The α-helix dipole is essential for their voltage-dependent pore formation in lipid bilayer membranes, which is explained by a flip-flop gating mechanism based on dipole-dipole interactions of parallel and antiparallel arranged α-helices within oligomeric structures.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 187 (1930), S. 129-154 
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1. Es wurden die Gleichgewichte zwischen Thallium und Blei mit Thallium (1) chlorid und Bleichlorid irn Schmelzfluß untersucht.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 40 (1927), S. 600-600 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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