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Tumor host relations (1979)

Schaur, R. J. ; Semmelrock, H. -J. ; Schauenstein, E. ; [et al.]

Springer

Journal of cancer research and clinical oncology 93 (1979), S. 287-292

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ISSN: 1432-1335

Keywords: Plasma cortisol ; Tumor classification ; Breast ; Stomach ; Intestine ; Skin ; Gall bladder ; Lymph nodes ; Metastases

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The increase of plasma cortisol in patients with tumors of five different sites compared with a control group of patients with benign surgical diseases amounted to: +39% (breast), +34% (stomach), +86% (intestine), +60% (skin) and +194% (gall bladder). The first detectable increase of cortisol occurred in patients with tumors classified T2 according to the TNM scheme (+27% above the control). Highly significant increases were observed for T3 (+82%) and t4 (+77%) patients. Patients with palpable lymph nodes showed a most significantly increased cortisol mean value compared with patients without palbable lymph nodes. Similarly, the cortisol mean value of patients with distant metastases was significantly higher than the corresponding value of tumor patients without distant metastases. The question remains open, whether the primary site, the extent of the tumor or the occurrence of metastases is the main determinant for the cortisol increase.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00964585

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Pharmacokinetic data of propranolol enantiomers in a comparative human study with (S)- and (R,S)-propranolol (1989)

Lindner, W. ; Rath, M. ; Stoschitzky, K. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Chirality 1 (1989), S. 10-13

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ISSN: 0899-0042

Keywords: (S)-, (R,S)-propranolol ; pharmacokinetic ; human study ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The pharmacokinetics of (S)-propranolol were compared after the oral administration of a 40 mg dose of the pure enantiomer and an 80 mg dose of a racemic mixture of (R,S)-propranolol. The results of this study indicate that the bioavailability of (S)-propranolol, as expressed by the mean area uner the concentration-time curve (AUC) and maximum serum concentration, is lower after 40mg of the optically pure drug than after the racemic drug.

Additional Material: 2 Ill.