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  • 1
    Electronic Resource
    Electronic Resource
    Combined ultrastructural, histochemical, and autoradiographic study of osteosarcoma after preoperative chemotherapy according to the COSS 80 protocol (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 25-31 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Chemotherapy ; Electronmicroscopy ; Histochemistry ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twelve osteosarcomas treated according to the COSS 80 protocol (preoperative chemotherapy, resection) were studied by light and electron microscopic, histochemical, and autoradiographic methods. Evidence of regressive and necrotic changes was found in many tumor cells, but the alterations were unspecific. Viable tumor cells of high malignancy were also observed regularly, often at the S phase. As the tumor regression continued, a strong reaction of the mononuclear phagocyte system was manifested by the presence of macrophages and giant cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625048
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A possible reason for the phalloidin tolerance of hepatoma cells (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 305 (1978), S. 253-259 
    Details
    ISSN: 1432-1912
    Keywords: Phalloidin poisoning ; Isolated hepatocytes ; AS-30D hepatoma ; Contractile proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In contrast to normal liver cells, AS-30D hepatoma cells are insensitive to phalloidin. The lack of the typical phalloidin response in the latter cells is not due to a deficiency of contractile proteins. Actin prepared from hepatoma cells is able to form filamentous structures and is stabilized in a manner similar to muscle actin. Isolated liver cells were exposed to a medium containing phalloidin and removed after 20 min by centrifugation. The supernatant was inculated again with fresh cells. The procedure was repeated four times. The phalloidin response decreased to about 19% of the control because of the uptake of phalloidin during each incubation. When the same procedure was carried out with AS-30D hepatoma cells, and aliquots of the supernatants were tested with hepatocytes no marked decrease of the phalloidin response was seen. This indicates that hepatoma cells do not consume the toxin as do normal liver cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498819
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Morphology of pulmonary metastases from osteosarcoma during chemotherapy (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 241-248 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Osteosarcoma is known to metastasize rather early, and even after surgical resection of the primary metastases may occur predominantly in the lung. Administration of polychemotherapy for destruction of micrometastases has served to improve prognosis. Preoperative chemotherapy facilitates the evaluation of regression, another factor of high prognostic relevance. Morphologic analysis of pulmonary metastases developing during chemotherapy is of considerable interest on account of the potential therapy resistance of certain histologic subtypes of osteosarcoma. In the present study pulmonary metastases resected in 20 thoracotomies of 15 osteosarcoma patients were investigated by light microscopy and compared, if possible, to the respective primaries. All patients had received chemotherapy, predominantly according to the COSS 80 and COSS 82 protocols. The histologic picture of a tumor was found to change from the primary to the pulmonary metastasis, a pattern also verified in the lung metastases collected in consecutive thoracotomies from the same patient. Several different subtypes were regularly found side by side in the metastases, but generally no special sensitivity or resistance to chemotherapy could be attributed to any of these subtypes. Our results nevertheless do indicate an increased resistance of anaplastic tumor tissue. The response to chemotherapy agreed in 9 of 10 primaries with that of their metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00396380
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  • 4
    Electronic Resource
    Electronic Resource
    Hepatic failure in a patient treated with dacarbazine (DTIC) for malignant melanoma (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 281-286 
    Details
    ISSN: 1432-1335
    Keywords: Malignant Melanoma ; Chemotherapy ; Dacarbazine ; Toxicity ; Liver failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 55-year-old white woman received chemotherapy with DTIC after surgery for malignant melanoma (stage I, SSM IV, depth of invasion 12 mm). She died suddenly during the second treatment cycle. Autopsy revealed massive necrosis of the liver and thrombosis of the hepatic veins. The cause of the fatal outcome is attributed to the adverse toxic effects of DTIC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410649
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibitory effects of 4,4′-diisothiocyano stilbene-2,2′-disulfonic acid (DIDS) in the response of isolated hepatocytes to phalloidin (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 303-307 
    Details
    ISSN: 1432-1912
    Keywords: Phalloidin poisoning ; Isolated hepatocytes ; 4,4′-diisothiocyano stilbene-2,2′-disulfonic acid ; Plasma membranes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 4,4′-Diisothiocyano stilbene-2,2′-disulfonic acid (DIDS) inhibits the typical development of protrusions, regularly seen after treatment of isolated hepatocytes with phalloidin. The degree of inhibition depends on the time of preincubation and on the concentration of DIDS, but not on the concentration of phalloidin. DIDS is more effective than H2DIDS. The inhibition by both compounds is irreversible. The binding capacity of hepatocytes for H2DIDS is much higher than that of the phalloidin-insensitive hepatoma cells. Gel electrophoresis of lysates from cells, pretreated with 3H2DIDS demonstrates that actin binds very little of the inhibitor. Our results suggest that a protein structure on the surface of hepatocytes, needed for the response to phalloidin, is influenced by DIDS or H2DIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507973
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    Paper (German National Licenses)
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