ISSN:
1432-1335
Keywords:
Osteosarcoma
;
Chemotherapy
;
Electronmicroscopy
;
Histochemistry
;
Autoradiography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Twelve osteosarcomas treated according to the COSS 80 protocol (preoperative chemotherapy, resection) were studied by light and electron microscopic, histochemical, and autoradiographic methods. Evidence of regressive and necrotic changes was found in many tumor cells, but the alterations were unspecific. Viable tumor cells of high malignancy were also observed regularly, often at the S phase. As the tumor regression continued, a strong reaction of the mononuclear phagocyte system was manifested by the presence of macrophages and giant cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00625048
Permalink