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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacology of Antidiarrheal Drugs (1983)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 23 (1983), S. 279-301 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.23.040183.001431
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  • 2
    Electronic Resource
    Electronic Resource
    Propoxate ( R 7464) : a New Potent Anaesthetic Agent in Cold-blooded Vertebrates (1965)
    [s.l.] : Nature Publishing Group
    Nature 205 (1965), S. 1018-1019 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Experiments with goldfish have been carried out in 101 aerated aquaria kept at 19 ± 2 C. Concentrations of R7464: 1/1.6, 1/4, 1, 4, 16 and 64 p.p.m., were tested at various immersion times, 1/64, 1/16, 1/4, 1, 4 and 16 h. Recovery from anaesthesia was effected by transferring the fish into ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2051018a0
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  • 3
    Electronic Resource
    Electronic Resource
    Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1657-1659 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Oxatomide is a new potent inhibitor of anaphylactic and allergic reactions. After oral administration, the compound both inhibits the release of endogenous histamine and prevents the effects of exogenous histamine, at comparable doses. The combination of these effects appears to be the basis of the effectiveness of oxatomide in allergic reactions and may lead to clinical applications different from classical antihistaminics and from cromoglycate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01934056
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  • 4
    Electronic Resource
    Electronic Resource
    Antiemetic effect of haloperidol in the dog as related to plasma level and dose (1981)
    Springer
    Psychopharmacology 75 (1981), S. 240-244 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Plasma concentration ; Antiemetic effect ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A positive and highly significant correlation was found between SC dose, plasma concentration, and antiemetic effect of haloperidol in the dog. To protect dogs from apomorphine-induced emesis, a concentration of 1 ng haloperidol/ml plasma was always sufficient, whereas protection from emesis was never obtained with plasma levels lower than 0.53 ng/ml. The elimination rate of haloperidol from plasma varied from 1.53 to 2.60 among different animals. Thus, the interindividual variability to haloperidol was surprisingly low. Antiemetic effect and plasma elimination of haloperidol were not related to body weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432431
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  • 5
    Electronic Resource
    Electronic Resource
    A putative multipartite model of haloperidol interaction in apomorphine-disturbed behavior of the dog (1978)
    Springer
    Psychopharmacology 59 (1978), S. 255-258 
    Details
    ISSN: 1432-2072
    Keywords: Dog ; Self-stimulation ; Apomorphine ; Haloperidol ; Stimulus control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction between various doses of apomorphine and haloperidol on intracranial self-stimulation in the dog was studied using a pradigm in which reinforcing brain-stimulation was controlled by a discriminative auditory stimulus. Reinforced leverpressing was decreased by low doses of apomorphine and completely suppressed by stereotypogenic doses. At various doses of apomorphine, low doses of haloperidol either increased response inhibition by enhancing stereotypy, or increased lever pressing by reducing stereotypy while concomitantly increasing the number of nonreinforced responses. Intermediate to relatively high doses of haloperidol antagonized stereotypy and the response inhibition produced by apomorphine. High doses of haloperidol antagonized stereotypy but also suppressed self-stimulation. Thus, haloperidol is not only able to restore performance capability, but also disturbed reinforcing and discriminative stimulus control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426630
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  • 6
    Electronic Resource
    Electronic Resource
    Bromperidol, a new butyrophenone neuroleptic: A review (1982)
    Springer
    Psychopharmacology 78 (1982), S. 1-7 
    Details
    ISSN: 1432-2072
    Keywords: Bromperidol ; Haloperidol ; Chlorpromazine ; Preclinical review ; Animal pharmacology ; Animal pharmacokinetics ; Animal biotransformation ; Animal drug safety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic, haloperidol, and the phenothiazine neuroleptic chlorpromazine. Its pharmacokinetics, biotransformation, and safety in several laboratory animal species are also summarized. These preclinical data support its use as an antipsychotic agent and show that it is well absorbed following oral administration with an apparent elimination half-life of approximately 24 h, supporting a once-daily dose regimen. Animal toxicity (including acute- and multiple-dose toxicology and reproductive and mutagenicity studies) show that bromperidol is well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470578
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  • 7
    Electronic Resource
    Electronic Resource
    Antiemetic specificity of dopamine antagonists (1982)
    Springer
    Psychopharmacology 78 (1982), S. 210-213 
    Details
    ISSN: 1432-2072
    Keywords: Neuroleptics ; Antiemetics ; Antiemetic specificity ; Dogs ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve antagonists of apomorphine-induced emesis in dogs were studied in different tests to evaluate their antiemetic specificity. Ten of these antagonists were neuroleptics: benzquinamide, clebopride, bromopride, prochlorperazine, haloperidol, chlorpromazine, thiethylperazine, metoclopramide, droperidol, and pimozide blocked conditioned responding in dogs and apomorphine-induced stereotyped behavior in rats. The use of these compounds as anti-emetics entails a risk of neurological side effects. Metopimazine and domperidone were devoid of neuroleptic activity. Metopimazine, however, showed potent α-adrenergic blocking activity, showed histamine H1 antagonism, and induced palpebral ptosis. Therapeutic doses of metopimazine are, therefore, likely to produce sedation and side-effects related to autonomic blockade. Domperidone showed potent antiemetic activity and, up to high doses, no other central or peripheral effects. Therefore, domperidone is the only specific antiemetic known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428152
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  • 8
    Electronic Resource
    Electronic Resource
    Behavioral and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rat (1985)
    Springer
    Psychopharmacology 86 (1985), S. 45-54 
    Details
    ISSN: 1432-2072
    Keywords: 5-HT antagonist ; LSD antagonist ; Drug discrimination ; Anxiety ; 5-HTP ; Head twitch ; Conflict behavior ; Hypothermia ; Ritanserin ; Pirenperone ; Chlordiazepoxide ; Diazepam ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The newly synthesized compound and putative 5-HT2 antagonist ritanserin, but not the structurally related compound R 56413, resembles pirenperone in that it acts as a pure antagonist in an LSD-saline drug discrimination assay in the rat. Ritanserin exceeded pirenperone in terms of behavioral specificity; the lowest effective dose of ritanserin in antagonizing LSD was one order of magnitude higher than that of pirenperone, but the compound depressed rate of operant responding only at doses that were about 1000-fold higher than those at which pirenperone was effective. Ritanserin exerted effects in an open field test which were reminiscent of anxiolytic drug activity in the rat; its effects were greater than those of pirenperone, R 56413 and the benzodiazepines chlordiazepoxide and diazepam. The results of experiments on antagonism of 5-HT-induced hypothermia and of the 5-HTP-induced headtwitch response fail to support the possibility that the putative anxiolytic effects of ritanserin in the rat can be ascribed simply to a pharmacologically defined action at 5-HT receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431683
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  • 9
    Electronic Resource
    Electronic Resource
    Tetramisole ( R 8299), A New, Potent Broad Spectrum Anthelmintic (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 1084-1086 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THIS article reports the discovery of tetramisole (R 8299 (I)), a new, potent broad spectrum anthelmintic, which is at present undergoing large-scale clinical trials in several countries. In the course of our routine screening programme for anthelmintic activity the aminothiazol derivative (II) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2091084a0
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  • 10
    Electronic Resource
    Electronic Resource
    Levocabastine: Pharmacological profile of a highly effective inhibitor of allergic reactions (1992)
    Springer
    Inflammation research 35 (1992), S. 12-18 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Levocabastine, selected from a series of cyclohexylpiperidine derivatives protects rats from compound 48/80-induced anaphylactic shock for at least 16 h at the oral dose of 0.0015 mg/kg. At the same dose histamine skin reactions and at slightly higher doses passive cutaneous anaphylactic reactions are inhibited. Blockade of passive cutaneous anaphylactic reactions is obtained with levocabastine, despite absence of peripheral serotonin antagonism and any other known non-specific action that may facilitate inhibition of passive anaphylaxis. In dogs allergic reactions are inhibited at oral doses 40 times lower than ketotifen. In guinea-pigs orally and topically administered levocabastine are remarkably effective against allergic conjunctivitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990945
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