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  • Contrast medium  (1)
  • En-bloc Perfusion  (1)
  • High risk  (1)
  • 1
    ISSN: 1432-2277
    Keywords: Key words Tacrolimus ; Cyclosporine ; Kidney transplantation ; High risk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens were compared in a prospectively defined subgroup of kidney transplant recipients from the European, open, multicentre, 2 : 1 randomised, parallel group study. Patients were stratified as high risk for immunological events if they had a panel-reactive antibodies grade greater than 80 % and/or a previous transplant functional for less than 1 year. The primary efficacy variables evaluated were the incidence of acute rejection, steroid usage and patient and graft survival. Safety was assessed based on adverse events and laboratory evaluations. At 1 year, the tacrolimus group (n = 22) had a lower incidence of biopsy-proven acute rejection (31.8 %) and a higher graft survival (86.0 %) than the 11 patients in the cyclosporine group (54.5 % and 72.0 %, respectively). The frequencies of adverse events were similar between the two groups. The tacrolimus regimen appears more beneficial for high risk patients than cyclosporine.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Magnetresonanztomographie ; Nierentransplantate ; Kontrastmittel ; Key words MR imaging ; Renal allografts ; Contrast medium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: To determine the value of MR imaging in differentiating the various causes of human renal allograft dysfunction. Methods: A total of 123 human renal allografts (normal n = 20, acute rejection n = 57, acute tubular necrosis n = 14, interstitial fibrosis n = 11, chronic allograft glomerulopathy n = 11, cyclosporine nephrotoxicity n = 3, cortical necrosis n = 7) were investigated by means of MR imaging. Axial T1-weighted spin-echo images and coronal T1-weighted gradient-echo images were obtained before and after Gd-DTPA injection. Diagnostic parameters included corticomedullary contrast and allograft size and shape on the pre-contrast sequences. Results: None of the diagnostic parameters used could differentiate among the various diagnostic groups. Diagnosis of cortical necrosis could be made only on post-contrast scans. Contrast-enhanced scans were superior to pre-contrast images in detection of focal allograft lesions. Otherwise, contrast-enhanced scans did not provide any more information than pre-contrast studies. Spin-echo and gradient-echo sequences displayed the same diagnostic value. Conclusions: MR imaging has a limited value in differentiating the various causes of renal allograft dysfunction.
    Notes: Zusammenfassung Um den Stellenwert der MRT bei der Klärung der Fehlfunktion von Nierentransplantaten zu untersuchen, wurden 123 menschliche Nierentransplantate (unauffällig: n = 20, akute Rejektion: n = 57, akute tubuläre Nekrose: n = 14, interstitielle Fibrose: n = 11, Transplantatglomerulopathie: n = 11, Cyclosporinschaden: n = 3, kortikale Nekrose: n = 7) MR-tomographiert. An einem 1,5-T-Gerät wurden axiale T1-gewichtete Spinecho- und koronare T1-gewichtete Gradientenechoaufnahmen vor und nach Gabe von Gd-DTPA akquiriert. Als Beurteilungskriterien wurden der kortikomedulläre Kontrast sowie die Größe und Form des Transplantatorganes in der Nativuntersuchung herangezogen. Keines der Kriterien ermöglichte die Differenzierung der verschiedenen Diagnosegruppen. Abgesehen von der kortikalen Nekrose, die nur anhand der kontrastmittelunterstützten Sequenzen erkennbar war, lieferte die Gd-DTPA-Applikationen für die Differenzierung der verschiedenen parenchymalen Komplikationen keine Zusatzinformationen. Beim Nachweis fokaler Parenchymläsionen war die Kontrastmittelserie der Nativuntersuchungen überlegen. Die Spinecho- und Gradientenechoaufnahmen führten zu ähnlichen Resultaten. Schlußfolgernd kann davon ausgegangen werden, daß die statische MRT bei der Klärung der Fehlfunktion einer Transplantatniere eine untergeordnete Rolle spielt.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 530-530 
    ISSN: 1435-2451
    Keywords: Kidney donation ; Donor procurement ; En-bloc perfusion ; Nierenspende ; organerhaltende Therapie ; En-bloc Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Neben immunologischen Faktoren nimmt die Organqualität bei der Nierenspende eine Schlüsselposition für den Transplantationserfolg ein. Anhand von 110 Organentnahmen werden die wesentlichen organisatorischen und intensivmedizinischen Maßnahmen sowie die in Münster weiterentwickelte extracorporale transaortale Nierenperfusion dargestellt.
    Notes: Summary Besides immunological problems the anatomical and functional integrity of the transplanted kidney has a decisive influence on the outcome of kidney grafting. Using the data obtained from 110 kidneys explanted in Münster, we outline the essential regimen of donor procurement in an intensive care unit. A sophisticated technique in terms of extracorporeal transaortic en bloc graft perfusion is offered.
    Type of Medium: Electronic Resource
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