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  • 1
    Electronic Resource
    Electronic Resource
    Renal glucosyltransferase activity in highly-inbred spontaneously diabetic Chinese hamsters (1980)
    Springer
    Diabetologia 19 (1980), S. 40-44 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; Chinese hamsters ; kidney ; glucosyltransferase ; subline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A modified glucosyltransferase assay using degraded gelatin as acceptors was found to be enzyme concentration-and time-dependent in the Chinese hamster kidney extracts. In 54 Chinese hamsters selected from 7 highly inbred sublines with or without spontaneous glycosuria, the glucosyltransferase activity (0.78–3.25 unit/g) in the kidney was found to be significantly correlated (P=0.0002) to blood sugar concentrations (60–475 mg/dl). However, subline-dependent variation in glucosyltransferase activity was also evident and, in animals from 2 of the 5 diabetic sublines, similar activity of glucosyltransferase was found in their kidneys as in those of nondiabetic animals. It was concluded that renal glucosyltransferase activity was affected by blood sugar level as well as by genetically determined factor(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258309
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ciglitazone, a new hypoglycaemic agent. 3. effect on glucose disposal and gluconeogenesis in vivo in C57BL/6J-Ob/Ob and — +/? Mice (1983)
    Springer
    Diabetologia 25 (1983), S. 514-520 
    Details
    ISSN: 1432-0428
    Keywords: Ciglitazone ; C57BL/6J-ob/ob mice and their lean littermates ; glucose turnover rate in vivo ; gluconeogenesis in vivo ; Cori cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J- +/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of radiolabelled glucose at 15, 30, 45, and 60 min after injection. The rate constants of glucose turnover were calculated to be as follows in decreasing order: treated obese (0.046/min), treated lean (0.032/min), control lean (0.026/min), and control obese (0.022/min). The obese mice showed less futile Cori cycle activity than the lean mice and ciglitazone had negligible effect on glucose recycling. The control obese mice incorporated more radiolabels in hepatic lipids, glycogen, and proteins than the control lean mice and ciglitazone further enhanced the incorporations. Ciglitazone also increased hepatic accumulations of radiolabels in the glycogen and lipid fractions in the lean littermates. Using lactate-14C as precursor, gluconeogenesis in vivo was measured in control and treated obese and lean mice. Ciglitazone significantly lowered the rate of conversion of lactate-14C to glucose-14C in the obese mice but not in the lean littermates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284462
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Ifosfamide, carboplatin and etoposide (ICE) in metastatic and refractory breast cancer (1999)
    Springer
    Cancer chemotherapy and pharmacology 44 (1999), S. S26 
    Details
    ISSN: 1432-0843
    Keywords: Keywords Ifosfamide ; Carboplatin ; Etoposide ; Metastatic breast cancer ; Salvage therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-five patients with metastatic breast cancer were treated with ICE after failure of previous chemotherapy. Their median age was 50 years (range 36–73). All but 1 patient had multiple sites of metastases. Nineteen (76%) patients had undergone two or more chemotherapy regimens for metastatic disease prior to ICE. The performance status (PS) of the patients was Eastern Cooperative Oncology Group (ECOG) 0:6; 1:12; 2:5; 3:2. Ifosfamide 1.25 g/m2 over 3 h D1-3 along with mesna, etoposide 80 mg/m2 D1-3 and carboplatin 300 mg/m2 D1 were given every 3 weeks. We observed a partial response in 10 patients (40%, 95% confidence interval 21–62%). The response duration ranged from 1 to 15 months with a median duration of 4.5 months. The survival of all 25 patients ranged from 10 days to 25 months, with a median of 9 months. All 25 patients were evaluable for toxicity. Thirteen patients (52%) experienced grade 4 hematological toxicity, which improved after growth factor support. Four patients had leukopenic fever, 1 had gram-negative sepsis, while 2 had Clostridium difficile enterocolitis and another had herpes zoster reactivation. Four patients (16%) experienced grade 3–4 gastrointestinal (G-I) toxicity. No hepatic or renal toxicity was observed (1 patient had microscopic hematuria). One patient died of G-I bleed, and another patient died at home of undetermined cause. We conclude that ICE is an effective salvage regimen in metastatic and refractory breast cancer, even in heavily pretreated patients, and is a tolerable treatment when used with growth factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051113
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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