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  • 1
    Electronic Resource
    Electronic Resource
    Human corticotropin-releasing factor (hCRF) is a potent respiratory analeptic (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 924-928 
    Details
    ISSN: 1432-1440
    Keywords: Human corticotropin-releasing factor (hCRF) ; Biological activity ; Respiratory analeptic ; Human beings ; Hyperventilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During intravenous corticotropin-releasing factor stimulation tests we observed a deepening of the tidal volume in 35 patients. To investigate this presumed respiratory stimulation we measured respiratory parameters in 12 healthy male volunteers in a single-blind placebo-controlled trial. The intravenous 60-s infusion of 100 µg of human corticotropin-releasing factor induced a very potent respiratory stimulation in every subject: respiratory minute volume (mean ± S.D.) increased by 81% from 6.319±0.577 to 11.464±1.264 liters per min (P〈0.001), whereas there was only a slight rise in the mean respiratory rate from 12.4±3.0 to 14.7±2.7 breaths per min (P〈0.001). Mean tidal volume increased from 531±105 to 809±175 ml (P〈0.001). Mean end-tidal partial pressure of carbon dioxide decreased (P〈0.001) from 40.3±1.2 to 33.4±1.2 mmHg, whereas mean end-tidal partial pressure of oxygen increased (P〈0.001) from 93.2±5.4 to 113.5±5.4 mmHg. After 10 to 20 min both end-tidal carbon dioxide and oxygen partial pressures returned to the baseline values. The placebo had no measurable effects. We conclude that human corticotropin-releasing factor is a potent respiratory stimulant. With 100 µg the resting respiratory minute volume increases by 81%. These data point to the possible importance of the corticotropin-releasing factor as a useful adjunct in the management of patients with alveolar hypoventilation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728617
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  • 2
    Electronic Resource
    Electronic Resource
    Architecture in cortical bone and ultrasound transmission velocity (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 364-367 
    Details
    ISSN: 1434-9949
    Keywords: Ultrasound ; Cortical bone ; Mechanical Properties ; Architecture ; Modulus of Elasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The square of ultrasound transmission velocity in a material is correlated to the modulus of elasticity, which is an indicator of its mechanical properties. This might make the measurement of ultrasound transmission velocity useful in the noninvasive diagnosis of bone diseases. Bone, however, is not an isotropic material but is architecturally structured. The aim of our study was to investigate and especially to quantify the influence of architecture in cortical bone on ultrasound transmission velocity. Twenty-two rectangular, flat specimens of cortical bone were prepared from diaphysis of fresh pig radius. Ultrasound transmission velocity was measured parallel and perpendicular to direction of Haversian channels. It was found to be 3647 ± 41 m/s parallel to and 2821 ± 29 m/s perpendicular to Haversian channels respectively (p〈0.001). Our results clearly indicate that there is an important influence of architecture in cortical bone on ultrasound transmission velocity which has to be taken into account in its clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231581
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    Paper (German National Licenses)
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