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  • 1
    Electronic Resource
    Electronic Resource
    The effect of human proinsulin C-peptide on erythrocyte deformability in patients with Type I diabetes mellitus (1999)
    Springer
    Diabetologia 42 (1999), S. 465-471 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Proinsulin C-peptide ; erythrocyte deformability ; microcirculation ; laser diffractoscopy ; shear stress.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. In recent years, evidence has arisen that proinsulin C-peptide exerts biological effects especially on microcirculation, e. g. C-peptide has been shown to increase skin microcirculation in patients with Type I (insulin-dependent) diabetes mellitus and to activate endothelial nitric oxide synthase. This study aimed to investigate the influence of proinsulin C-peptide on erythrocyte deformability which was assessed by means of laser diffractoscopy. Methods. Blood samples from healthy control subjects (n = 10) and Type I diabetic patients (n = 15) completely deficient of C-peptide were analysed at shear stresses ranging from 0.3 to 30 Pa. Results. Erythrocyte deformability was lower in the group of Type I diabetic patients than in the control subjects. Preincubation of the diabetic blood samples with various concentrations of human proinsulin C-peptide for 8 h restored the deformability of erythrocytes, almost reaching the values of control samples. In contrast, proinsulin C-peptide did not modify the erythrocyte deformability of control subjects. Conclusion/interpretation. We conclude that proinsulin C-peptide is able to ameliorate the impaired deformability of erythrocytes in Type I diabetic patients and we hypothesise that this effect is mediated by restoration of Na+-K+-ATPase activity, which is known to be attenuated in diabetic patients. [Diabetologia (1999) 42: 465–471]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051180
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  • 2
    Electronic Resource
    Electronic Resource
    Autoantibodies to the islet antigen ICA 69 occur in IDDM and in rheumatoid arthritis (1995)
    Springer
    Diabetologia 38 (1995), S. 351-355 
    Details
    ISSN: 1432-0428
    Keywords: Key words ICA 69 ; insulin-dependent diabetes mellitus; rheumatoid arthritis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet cell antigen (ICA) 69 is a newly-recognized islet cell antigen to which autoantibodies have been observed in prediabetic relatives of patients with insulin-dependent-diabetes mellitus (IDDM). Here we extend the earlier analysis of ICA 69 antibodies to patients with recent-onset IDDM and to patients with other immune-mediated diseases. ICA 69 antibodies were determined by Western blot using an affinity purified recombinant fusion protein of ICA 69 and maltose binding protein. ICA 69 antibody quantities were determined as titres using a titration curve of a standard serum as reference. Mean logarithmic ICA 69 antibody titres were 3.4 (± 1.4) in 99 patients with acute IDDM compared to 2.8 (± 0.9) in 49 healthy blood donors (p 〈 0.001). A higher mean ICA 69 antibody titre of 4.1 (± 0.8) was observed in 16 patients with rheumatoid arthritis in comparison to acute IDDM (p 〈 0.01) and healthy control subjects (p 〈 0.001). The percentage of sera with ICA 69 antibody titres above the 2 SD level of normal subjects was 21 % in IDDM, 31 % in rheumatoid arthritis and 6 % in healthy blood donors. None of the patients with autoimmune thyroid disease (n = 20), inflammatory bowel disease (n = 9) or multiple sclerosis (n = 7) had elevated ICA 69 antibodies. In IDDM, presence of ICA 69 antibodies persisted and the titre remained the same over 18 months of follow-up. The relationship of ICA 69 antibodies to islet cell antibodies (ICA) or insulin autoantibodies (IAA) was tested. The production of ICA 69 antibodies was not associated in diabetic patients with the presence of any of the two other autoantibodies. In conclusion, this study describes ICA 69 antibodies in acute IDDM and finds them to be independent of other islet autoantibodies. In addition ICA 69 is a target of humoural autoimmunity not only in IDDM but also in rheumatoid arthritis. [Diabetologia (1995) 38: 351–355]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400641
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  • 3
    Electronic Resource
    Electronic Resource
    Autoantibodies to the islet antigen ICA 69 occur in IDDM and in rheumatoid arthritis (1995)
    Springer
    Diabetologia 38 (1995), S. 351-355 
    Details
    ISSN: 1432-0428
    Keywords: ICA 69 ; insulin-dependent diabetes mellitus ; rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet cell antigen (ICA) 69 is a newly-recognized islet cell antigen to which autoantibodies have been observed in prediabetic relatives of patients with insulin-dependent-diabetes mellitus (IDDM). Here we extend the earlier analysis of ICA 69 antibodies to patients with recent-onset IDDM and to patients with other immune-mediated diseases. ICA 69 antibodies were determined by Western blot using an affinity purified recombinant fusion protein of ICA 69 and maltose binding protein. ICA 69 antibody quantities were determined as titres using a titration curve of a standard serum as reference. Mean logarithmic ICA 69 antibody titres were 3.4 (±1.4) in 99 patients with acute IDDM compared to 2.8 (±0.9) in 49 healthy blood donors (p〈0.001). A higher mean ICA 69 antibody titre of 4.1 (±0.8) was observed in 16 patients with rheumatoid arthritis in comparison to acute IDDM (p〈0.01) and healthy control subjects (p〈0.001). The percentage of sera with ICA 69 antibody titres above the 2 SD level of normal subjects was 21% in IDDM, 31% in rheumatoid arthritis and 6% in healthy blood donors. None of the patients with autoimmune thyroid disease (n=20), inflammatory bowel disease (n=9) or multiple sclerosis (n=7) had elevated ICA 69 antibodies. In IDDM, presence of ICA 69 antibodies persisted and the titre remained the same over 18 months of follow-up. The relationship of ICA 69 antibodies to islet cell antibodies (ICA) or insulin autoantibodies (IAA) was tested. The production of ICA 69 antibodies was not associated in diabetic patients with the presence of any of the two other autoantibodies. In conclusion, this study describes ICA 69 antibodies in acute IDDM and finds them to be independent of other islet autoantibodies. In addition ICA 69 is a target of humoural autoimmunity not only in IDDM but also in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400641
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  • 4
    Electronic Resource
    Electronic Resource
    Association between “diabetic thick skin syndrome” and neurological disorders in diabetes mellitus (1994)
    Springer
    Acta diabetologica 31 (1994), S. 73-77 
    Details
    ISSN: 1432-5233
    Keywords: Diabetes mellitus ; Skin thickness ; Diabetic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Skin thickness on the extremities of patients with diabetes mellitus has been described controversially. Using high resolution ultrasonography, we were able to show a significant increase in skin thickness at the forearm (P〈0.05), thigh (P〈0.001) and lower limb (P〈0.05) of diabetic patients, most prominent at the thigh. No difference in skin thickness was found at the dorsum of the foot. In addition, skin thickness was not related to the duration of diabetes, age or HbA1. A close association was found between diabetic neuropathy and increasing skin thickness. Diabetic patients with neurological disorders had a significant increase in skin thickness versus diabetic patients without neuropathy. The present findings suggest that diabetic neuropathy and abnormalities of connective tissue have a common etiological link in their development or that both are time-dependent processes. Whether changes in capillary blood flow, increase of nonenzymatic glycosylation, polyol accumulation or other metabolic disorders are responsible for these findings remains still to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570538
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  • 5
    Electronic Resource
    Electronic Resource
    Is there an ectopic secretion of monomeric calcitonin in the human being? (1998)
    Springer
    Langenbeck's archives of surgery 383 (1998), S. 456-459 
    Details
    ISSN: 1435-2451
    Keywords: Key words Calcitonin ; Thyroidectomy ; Ectopic production ; Differentiated thyroid carcinoma ; Follow-up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Introduction: Persistent detectable calcitonin (CT) values can be frequently observed after treatment of medullary thyroid carcinomas (MTCs). Apart from residual C cells or incomplete tumor extirpation, ectopic CT production should be taken into account. CT determination in patients without MTC and after total thyroidectomy should reveal to what extent, apart from the C cells, other neuroendocrine cells show a relevant CT production. Objectives: The objective of this study was to find out whether ectopic CT production can be detected using an assay specifically recognizing the monomeric form of CT. Methods: The CT serum values were obtained from 94 healthy individuals and 64 patients who had undergone total thyroidectomy and radioiodine therapy because of follicular or papillary carcinoma. Results: In the group of thyroidectomized patients, the CT values were below the detection limit of the assay. In the tested patients, there was neither a physiological (C cell) nor a pathological (MTC cell) secretion of monomeric CT. Conclusion: A relevant ectopic monomeric CT production could be excluded because the patients were without detectable CT concentration. For this reason, postoperative CT concentrations of the monomeric form in MTC patients can be traced either to remaining C cells or to tumor cells. For a differentiation of these two possibilities further diagnostics is necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050160
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  • 6
    Electronic Resource
    Electronic Resource
    Architecture in cortical bone and ultrasound transmission velocity (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 364-367 
    Details
    ISSN: 1434-9949
    Keywords: Ultrasound ; Cortical bone ; Mechanical Properties ; Architecture ; Modulus of Elasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The square of ultrasound transmission velocity in a material is correlated to the modulus of elasticity, which is an indicator of its mechanical properties. This might make the measurement of ultrasound transmission velocity useful in the noninvasive diagnosis of bone diseases. Bone, however, is not an isotropic material but is architecturally structured. The aim of our study was to investigate and especially to quantify the influence of architecture in cortical bone on ultrasound transmission velocity. Twenty-two rectangular, flat specimens of cortical bone were prepared from diaphysis of fresh pig radius. Ultrasound transmission velocity was measured parallel and perpendicular to direction of Haversian channels. It was found to be 3647 ± 41 m/s parallel to and 2821 ± 29 m/s perpendicular to Haversian channels respectively (p〈0.001). Our results clearly indicate that there is an important influence of architecture in cortical bone on ultrasound transmission velocity which has to be taken into account in its clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231581
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  • 7
    Electronic Resource
    Electronic Resource
    NMR-spektroskopische Untersuchungen an 15N-markierten N-Phosphorylphosphazenen und Imidodiphosphorsäure-DerivatenProfessor Hans-Albert Lehmann zum 65. Geburtstage am 1. Mai 1984 gewidmet (1984)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 511 (1984), S. 7-18 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: N.M.R. Spectroscopic Studies of 15N Labelled N-Phosphorylphosphazenes and Imidodiphosphoric Acid Derivatives15N labelled compounds were prepared and investigated by means of 31P- and 15N-NMR spectroscopy. The chemical shift values δP and δN, and the coupling constants 1JPN and 2JPP are discussed and interpreted qualitatively by semiempirical quantumchemical calculations (CNDO/2) using POPLE'S ΔE-model.
    Notes: 15N-markierte Verbindungen der Substitutionsreihen wurden synthetisiert und mit Hilfe der 31P- und 15N-NMR-Spektroskopie untersucht. Die chemischen Verschiebungen δP und δN sowie die Kopplungskonstanten 1JPN und 2JPP werden diskutiert und qualitativ mit Hilfe halbempirischer quantenchemischer Rechnungen (CNDO/2) im Rahmen des POPLE-schen ΔE-Modells interpretiert.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19845110402
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  • 8
    Electronic Resource
    Electronic Resource
    Bildung und NMR-spektroskopische Charakterisierung von Alk-(ar-)oxyderivaten von Trichlorphosphazen-N-phosphoryldichlorid, Cl3P=N—P(O)Cl2, Imido- und N-Methylimidodiphosphoryltetrachlord, Cl2P(O)NHP(O)Cl2 bzw. Cl2P(O)N(CH3)P(O)Cl2Professor Hans-Albert Lehmann zum 65. Geburtstage am 1. Mai 1984 gewidmet (1984)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 511 (1984), S. 33-40 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Formation and N.M.R.-Spectroscopic Characterization of Alk-(ar-)oxy Derivatives of Trichlorophosphazene-N-phosphoryldichloride, Cl3P=N—P(O)Cl2, Imido- and N-Methylimidodiphosphoryltetrachloride, Cl2P(O)NHP(O)Cl2 and Cl2P(O)N(CH3)P(O)Cl2The ester chlorides and esters P2NOCl5-x(OR)x (x = 1-5), P2(NH)O2Cl4-x(OR)x (x = 1-4) and P2(NCH3)O2Cl4-x(OR)x (x = 1-4) derived from the title compounds by substitution of chlorine atoms by alk- or aroxy groups are characterized by their 31P-n.m.r. data. The possibilities for forming these compounds by alcoholysis, chloridolysis, dealkylation and P—N-bond formation are discussed.
    Notes: Die sich von den Titelverbindungen durch Substitution der Chloratome durch Alk- bzw. Aroxygruppen ableitenden Esterchloride und Ester P2NOCl5-x(OR)x (x = 1-5), P2(NH)O2Cl4-x(OR)x (x = 1-4) und P2(NCH3)O2Cl4-x(OR)x(x = 1-4) werden 31P-NMR-spektroskopisch charakterisiert. Die Möglichkeiten zur Bildung dieser Verbindungen durch Alkoholyse, Chloridolyse, Entalkylierungs- und P—N-Bindungsknüpfungsreaktionen werden vorgestellt.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19845110404
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  • 9
    Electronic Resource
    Electronic Resource
    NMR-spektroskopische Untersuchungen an 15N-markierten N-Methyl-imidodiphosphorsäure-Derivaten (1985)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 525 (1985), S. 7-13 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: NMR Spectroscopic Studies of 15N Labelled N-Methyl-imidodiphosphoric Acid Derivatives15N labelled compounds (EtO)mCl2-m(O)P—NMe—P(O)(OEt)nCl2-n (m = 0-2, n = 0-2) were prepared as a mixture and investigated by means of 31P and 15N NMR spectroscopy. The chemical shift values δP and δN, and the coupling constants 1JPN and 2JPP are discussed and interpreted qualitatively by semiempirical quantumchemical calculations (CNDO/2) using POPLE'S ΔE-model.
    Notes: 15N-markierte Verbindungen der Substitutionsreihe (EtO)mCl2-m(O)P—NMe—P(O)(OEt)nCl2-n (m = 0-2, n = 0-2) wurden im Reaktionsgemisch synthetisiert und mit Hilfe der 31P- und 15N-NMR-Spektroskopie untersucht. Die chemischen Verschiebungen δP und δN sowie die Kopplungskonstanten 1JPN und 2JPP werden diskutiert und qualitativ mit Hilfe halbempirischer quantenchemischer Rechnungen (CNDO/2) im Rahmen des POPLE-schen ΔE-Modells interpretiert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19855250602
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