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  • 1
    Electronic Resource
    Electronic Resource
    Autoantibodies to the islet antigen ICA 69 occur in IDDM and in rheumatoid arthritis (1995)
    Springer
    Diabetologia 38 (1995), S. 351-355 
    Details
    ISSN: 1432-0428
    Keywords: Key words ICA 69 ; insulin-dependent diabetes mellitus; rheumatoid arthritis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet cell antigen (ICA) 69 is a newly-recognized islet cell antigen to which autoantibodies have been observed in prediabetic relatives of patients with insulin-dependent-diabetes mellitus (IDDM). Here we extend the earlier analysis of ICA 69 antibodies to patients with recent-onset IDDM and to patients with other immune-mediated diseases. ICA 69 antibodies were determined by Western blot using an affinity purified recombinant fusion protein of ICA 69 and maltose binding protein. ICA 69 antibody quantities were determined as titres using a titration curve of a standard serum as reference. Mean logarithmic ICA 69 antibody titres were 3.4 (± 1.4) in 99 patients with acute IDDM compared to 2.8 (± 0.9) in 49 healthy blood donors (p 〈 0.001). A higher mean ICA 69 antibody titre of 4.1 (± 0.8) was observed in 16 patients with rheumatoid arthritis in comparison to acute IDDM (p 〈 0.01) and healthy control subjects (p 〈 0.001). The percentage of sera with ICA 69 antibody titres above the 2 SD level of normal subjects was 21 % in IDDM, 31 % in rheumatoid arthritis and 6 % in healthy blood donors. None of the patients with autoimmune thyroid disease (n = 20), inflammatory bowel disease (n = 9) or multiple sclerosis (n = 7) had elevated ICA 69 antibodies. In IDDM, presence of ICA 69 antibodies persisted and the titre remained the same over 18 months of follow-up. The relationship of ICA 69 antibodies to islet cell antibodies (ICA) or insulin autoantibodies (IAA) was tested. The production of ICA 69 antibodies was not associated in diabetic patients with the presence of any of the two other autoantibodies. In conclusion, this study describes ICA 69 antibodies in acute IDDM and finds them to be independent of other islet autoantibodies. In addition ICA 69 is a target of humoural autoimmunity not only in IDDM but also in rheumatoid arthritis. [Diabetologia (1995) 38: 351–355]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400641
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  • 2
    Electronic Resource
    Electronic Resource
    Autoantibodies to the islet antigen ICA 69 occur in IDDM and in rheumatoid arthritis (1995)
    Springer
    Diabetologia 38 (1995), S. 351-355 
    Details
    ISSN: 1432-0428
    Keywords: ICA 69 ; insulin-dependent diabetes mellitus ; rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet cell antigen (ICA) 69 is a newly-recognized islet cell antigen to which autoantibodies have been observed in prediabetic relatives of patients with insulin-dependent-diabetes mellitus (IDDM). Here we extend the earlier analysis of ICA 69 antibodies to patients with recent-onset IDDM and to patients with other immune-mediated diseases. ICA 69 antibodies were determined by Western blot using an affinity purified recombinant fusion protein of ICA 69 and maltose binding protein. ICA 69 antibody quantities were determined as titres using a titration curve of a standard serum as reference. Mean logarithmic ICA 69 antibody titres were 3.4 (±1.4) in 99 patients with acute IDDM compared to 2.8 (±0.9) in 49 healthy blood donors (p〈0.001). A higher mean ICA 69 antibody titre of 4.1 (±0.8) was observed in 16 patients with rheumatoid arthritis in comparison to acute IDDM (p〈0.01) and healthy control subjects (p〈0.001). The percentage of sera with ICA 69 antibody titres above the 2 SD level of normal subjects was 21% in IDDM, 31% in rheumatoid arthritis and 6% in healthy blood donors. None of the patients with autoimmune thyroid disease (n=20), inflammatory bowel disease (n=9) or multiple sclerosis (n=7) had elevated ICA 69 antibodies. In IDDM, presence of ICA 69 antibodies persisted and the titre remained the same over 18 months of follow-up. The relationship of ICA 69 antibodies to islet cell antibodies (ICA) or insulin autoantibodies (IAA) was tested. The production of ICA 69 antibodies was not associated in diabetic patients with the presence of any of the two other autoantibodies. In conclusion, this study describes ICA 69 antibodies in acute IDDM and finds them to be independent of other islet autoantibodies. In addition ICA 69 is a target of humoural autoimmunity not only in IDDM but also in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400641
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  • 3
    Electronic Resource
    Electronic Resource
    HLA-DRB1* GENE SEQUENCES IN HLA-DR4 POSITIVE AND NEGATIVE PATIENTS WITH RHEUMATOID ARTHRITIS (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The second exon of the DRB1 gene encoding for the first domain of the HLA-DR β-chain was sequenced in 16 patients (10 DR4/DR1 positive, 6 DR4/DR1 negative) with seropositive rheumatoid arthritis (RA). We could confirm the strong association of susceptibility to RA with functionally equivalent conformations on otherwise distinct MHC molecules. At least one HLA-DR allele in all of the analysed DR4 or DR1 positive patients showed such an epitope with a minimal variability limited to residue 71.However, in HLA-DR4 and -DR1 negative patients such a similar epitope could not be detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00096.x
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  • 4
    Electronic Resource
    Electronic Resource
    Monoclonal antibodies to red cell cytoskeletal proteins
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 213 (1982), S. 334-337 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(82)90470-2
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  • 5
    Electronic Resource
    Electronic Resource
    Network Regulation among T Cells: Qualitative and Quantitative Studies on Suppression in the Non-Immune State (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 79 (1984), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1984.tb00487.x
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  • 6
    Electronic Resource
    Electronic Resource
    Reactivity Patterns of Synovial T-Cell Lines Derived from a Patient with Rheumatoid Arthritis. I. Reactions with Defined Antigens and Auto-Antigens Suggest the Existence of Multireactive T-Cell Clones (1997)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 46 (1997), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The functional T-cell repertoire in the inflamed joint of a patient with rheumatoid arthritis was analysed at the clonal level. Using limiting dilution techniques and selecting for growth of in vivo activated and/or autoreactive T cells, 149 T-cell lines were established. They were tested in a proliferation assay for reactivity against an autologous Epstein–Barr virus (EBV)-transformed B-cell line and a panel of auto-antigens and foreign antigens. Seventy-five lines (∼50%) could be stimulated. Thirty-six lines (∼24%) were antigen-reactive. They were stimulated by human collagens type I (15), II (10), IV (7) or V (4), cartilage proteoglycans (4), Mycobacterium tuberculosis (15), the 60 kDa heat-shock protein of M. bovis (13) or tetanus toxoid (10). T-cell lines were either monoreactive (19), bireactive (6), or multireactive (11), i.e. they were stimulated by either one, by two, or by more antigens in the panel. About half of the antigen-reactive lines were at the same time autoreactive towards the autologous B-cell line. These data suggest the existence of multispecific autoreactive T-cell receptors comparable to multireactive or natural autoantibodies and prove the presence of autoantigen-reactive T cells in the inflamed joints of patients with rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1997.d01-105.x
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  • 7
    Electronic Resource
    Electronic Resource
    Plasticity of T-Cell Function (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 30 (1989), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: EL-4 lymphoma cells are able to suppress the primary humoral immune response of spleen cells to sheep erythrocytes or 4-hydroxy-3-iodo-5-nitrophenylac-keyhole limpet haemocyanin (NIP-KLH (in vitro. Typically, the cells suppress very efficiently in small numbers, but lose this capacity as the numbers increase. Three clones were analysed and this fluctuation in function was paralleled by a fluctuation in the expression of CD8 (Ly-2). Clones were incubated for 2 days, starting from different seeding concentrations, and analysed with cytofluorography. Neither Thy-I nor CDS (Ly-1). H-2 K, H-2 D, LFA-1 (all positive) nor CD4 (L3T4) or MEL-14 (both negative) were influenced by this treatment. In contrast, cells were CD8- at high seeding concentrations, and CD8- at low seeding concentrations. When cell cultures grew to higher densities, the cells again lost the capacity to express CD8. Experiments testing the suppressive capacity of individual EL-4 clones after preculture at different densities or in the practice of antibodies against CD8 suggest that the efficiency of suppression may well be correlated to the amount ofCD8 expressed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1989.tb01193.x
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  • 8
    Electronic Resource
    Electronic Resource
    Network regulation among T cells; Conclusions from limiting dilution experiments (1983)
    Springer
    Springer seminars in immunopathology 6 (1983), S. 7-32 
    Details
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01857364
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  • 9
    Electronic Resource
    Electronic Resource
    HLA-DR1 and DRw6 association in DR4-negative rheumatoid arthritis patients (1990)
    Springer
    Rheumatology international 10 (1990), S. 171-175 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; HLA-DR antigens ; Conformational equivalence hypothesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study of 110 seropositive rheumatoid arthritis (RA) patients confirms the significant association of susceptibility to RA with HLA-DR4 specificity (P〈0.001). The DR1 frequency is elevated in the entire seropositive patient group, reaching marginal significance (P〈0.025). The DR4-negative patients, however, have a much higher prevalence of DR1 (P〈0.001). Surprisingly, the DRw6 specificity is significantly increased in the remaining DR4- and DR1-negative patients (P〈0.01). These results demonstrate that RA is not associated with a single HLA-specificity, but to various degrees with DR4, DR1, and DRw6. These findings, and particularly the newly recognized association with DRw6, support the hypothesis that functionally equivalent shared epitopes or conformations on otherwise distinct MHC molecules may confer risk for developing RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274843
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  • 10
    Electronic Resource
    Electronic Resource
    Anti-neutrophil cytoplasm antibodies (ANCA) in rheumatoid arthritis: relationship to HLA-DR phenotypes, rheumatoid factor, anti-nuclear antibodies and disease severity (1994)
    Springer
    Rheumatology international 14 (1994), S. 155-161 
    Details
    ISSN: 1437-160X
    Keywords: Anti-neutrophil cytoplasmic antibodies (ANCA) ; Rheumatoid arthritis ; HLA-DR antigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate a possible relationship between the presence of anti-neutrophil cytoplasm antibodies (ANCA), rheumatoid factors (RF), anti-nuclear antibodies (ANA), disease severity and HLA-DR phenotypes, 46 consecutive ANCA+ and 48 ANCA-, clinically well-documented RA patients were studied for RF, ANA and HLA-DR phenotypes. The 46 ANCA+ patients showed predominantly an atypical perinuclear staining pattern (89%). ANCA positivity was associated with higher RF titres (P〈0.005) and advanced functional Steinbrocker grades III/IV (P〈0.015). ANCA+ patients were also more often positive for ANA than ANCA- patients (P〈0.008). There was no correlation between ANCA positivity and certain HLA-DR phenotypes although the frequency of DR4+ (67% vs 52%) and, in particular, of DR4+ blanks (phenotypically homozygous) was increased in ANCA+ as compared to ANCA- patients (20% vs 8%). DR4-DR1- RA patients were twice as frequent in the ANCA- than in the ANCA+ group (22.9% vs 8.7%). Correspondingly, the DR4+DR1- phenotype was increased among ANCA+ RA patients. Regarding functional Steinbrocker grades, the DR4+ phenotypes were slightly but not significantly increased in grades III and IV whereas ANCA positivity was significantly associated with severe functional Steinbrocker grades III/IV (66% ANCA+ vs 39% ANCA-,P〈0.015). ANCA positivity identified a population of RA patients with a long-standing and severe clinical course of the disease. There was no correlation between ANCA positivity and certain HLA-DR phenotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00579701
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