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  • rheumatoid arthritis  (2)
  • Corticobasal degeneration  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The new neuropathology of degenerative frontotemporal dementias (1996)
    Springer
    Acta neuropathologica 91 (1996), S. 127-134 
    Details
    ISSN: 1432-0533
    Keywords: Key words Frontal lobe dementia ; Alzheimer's ; disease ; Pick's disease ; Corticobasal degeneration ; Motor neuron disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical features and recent developments in the neuropathology of frontotemporal dementia are reviewed. The five main neurodegenerative disorders that underlie the clinical syndrome of frontotemporal dementia are distinguished using immunohistochemistry with antisera to ubiquitin and tau proteins. Motor neuron disease-type dementia is characterised by ubiquitin-immunoreactive intraneuronal inclusions in cortical layer II and the hippocampal dentate granule cells. A diagnosis of Alzheimer's disease changes is based upon the presence of neurofibrillary tangles, which immunostain with antibodies to tau and ubiquitin, and many associated neuritic plaques. Corticobasal degeneration is diagnosed by the presence of tau-immunoreactive, but ubiquitin-non-reactive intraneuronal inclusions in cortical layer II and the substantia nigra. Pick's disease is restricted to cases with tau- and ubiquitin-immunoreactive spherical cortical intraneuronal inclusions (Pick bodies), best seen in the hippocampal dentate gyrus and frontotemporal cortex. Dementia of frontal type is the preferred term for cases in which no intraneuronal inclusions are seen with antisera to tau and ubiquitin. A practical approach to the pathological diagnosis of frontotemporal dementia and the differential diagnosis of the five disorders using immunohistochemical studies is provided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050403
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A phenylbutazone dose-finding study in rheumatoid arthritis (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 773-776 
    Details
    ISSN: 1432-1041
    Keywords: phenylbutazone ; rheumatoid arthritis ; dose ; oxyphenbutazone ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Different doses of phenylbutazone have been compared in a double blind study on 32 patients with rheumatoid arthritis in order to determine the minimum effective dose. Of 8 different dose levels studied (90 mg, 150 mg, 180 mg, 240 mg, 270 mg, 300 mg, 360 mg and 450 mg/day) the most efficacious was found to be 300 mg/day. Doses below this did not produce full benefit; no further improvement occurs with higher doses. Although 7/32 patients developed adverse reactions there was no relationship between these and the plasma levels of either phenylbutazone or oxyphenbutazone. An attempt was made to distinguish ‘responders’ from ‘non-responders’. We found no relationship between response and plasma levels of phenylbutazone or oxyphenbutazone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607086
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A pharmacological and clinical comparison of prednisolone and betamethasone in rheumatoid arthritis (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 321-325 
    Details
    ISSN: 1432-1041
    Keywords: prednisolone ; betamethasone ; rheumatoid arthritis ; adrenal suppression ; chronic dosage ; anti-inflammatory activities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. Two oral corticosteroids, prednisolone (8 mg/day) and betamethasone (1 mg/day) have been compared in terms of efficacy and adrenal suppressive activity when used in chronic oral dosage in rheumatoid arthritis. 2. 20 patients were entered to a single blind crossover study receiving each drug for a two-week period. Clinical and laboratory assessments were performed. 3. At this dosage there was no significant difference between any of the clinical parameters assessed for either drug though patient preference was 13 for prednisolone and 7 for betamethasone. 4. At this dosage adrenal suppression was not equivalent, being significantly more marked with betamethasone. 5. The results suggest that prednisolone is the drug of choice for chronic dosage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613613
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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