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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 36 (1964), S. 1356-1359 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 4 (1970), S. 128-128 
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 24 (1983), S. 773-776 
    ISSN: 1432-1041
    Keywords: phenylbutazone ; rheumatoid arthritis ; dose ; oxyphenbutazone ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Different doses of phenylbutazone have been compared in a double blind study on 32 patients with rheumatoid arthritis in order to determine the minimum effective dose. Of 8 different dose levels studied (90 mg, 150 mg, 180 mg, 240 mg, 270 mg, 300 mg, 360 mg and 450 mg/day) the most efficacious was found to be 300 mg/day. Doses below this did not produce full benefit; no further improvement occurs with higher doses. Although 7/32 patients developed adverse reactions there was no relationship between these and the plasma levels of either phenylbutazone or oxyphenbutazone. An attempt was made to distinguish ‘responders’ from ‘non-responders’. We found no relationship between response and plasma levels of phenylbutazone or oxyphenbutazone.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: prednisolone ; betamethasone ; rheumatoid arthritis ; adrenal suppression ; chronic dosage ; anti-inflammatory activities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. Two oral corticosteroids, prednisolone (8 mg/day) and betamethasone (1 mg/day) have been compared in terms of efficacy and adrenal suppressive activity when used in chronic oral dosage in rheumatoid arthritis. 2. 20 patients were entered to a single blind crossover study receiving each drug for a two-week period. Clinical and laboratory assessments were performed. 3. At this dosage there was no significant difference between any of the clinical parameters assessed for either drug though patient preference was 13 for prednisolone and 7 for betamethasone. 4. At this dosage adrenal suppression was not equivalent, being significantly more marked with betamethasone. 5. The results suggest that prednisolone is the drug of choice for chronic dosage.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 12 (1977), S. 213-219 
    ISSN: 1432-1041
    Keywords: Prednisolone pharmacokinetics ; intravenous dosing ; plasma clearance ; half-life ; volume of distribution ; plasma protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg·kg−1 and 0.3 mg·kg−1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Abstract Successions across the Middle–Upper Jurassic disconformity in the Lusitanian Basin (west-central Portugal) are highly varied, and were probably developed on a large westward-inclined hangingwall of a half-graben. The disconformity is preceded by a complex forced regression showing marked variations down the ramp, and provides an example of the effects of rapid, relative sea-level falls on carbonate ramp systems. In the east, Middle Jurassic inner ramp carbonates (‘Candeeiros’ facies) are capped by a palaeokarstic surface veneered by ferruginous clays or thick calcretes. In the west, mid-outer ramp marls and limestones (‘Brenha’ facies) are terminated by two contrasting successions: (1) a sharp-based carbonate sandbody capped by a minor erosion surface, overlain by interbedded marine–lagoonal–deltaic deposits with further minor erosion/exposure surfaces; (2) a brachiopod-rich limestone with a minor irregular surface, overlain by marls, lignitic marls with marine and reworked non-marine fossils and charophytic limestones, with further minor irregular surfaces and capped by a higher relief ferruginous erosional surface. The age ranges from Late Bathonian in the east to Late Callovian in the west. This disconformity assemblage is succeeded by widespread lacustrine–lagoonal limestones with microbial laminites and evaporites (‘Cabaços’ facies), attributed to the Middle Oxfordian. Over the whole basin, increasingly marine facies were deposited afterwards. In Middle Jurassic inner-ramp zones in the east, the overall regression is marked by a major exposure surface overlain by continental sediments. In Middle Jurassic outer-ramp zones to the west, the regression is represented initially by open-marine successions followed by either a sharp marine erosion surface overlain by a complex sandbody or minor discontinuities and marginal-marine deposits, in both cases capped by the major lowstand surface. Reflooding led to a complex pattern of depositional conditions throughout the basin, from freshwater and brackish lagoonal to marginal- and shallow-marine settings. Additional complications were produced by possible tilting of the hangingwall of the half-graben, the input of siliciclastics from westerly sources and climate change from humid to more seasonally semi-arid conditions. The Middle–Late Jurassic sea-level fall in the Lusitanian Basin is also recorded elsewhere within the Iberian and other peri-Atlantic regions and matches a transgressive to regressive change in eustatic sea-level curves, indicating that it is related in part to a global event.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 39 (1992), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Thick dolomite-cemented horizons (dolocretes) occur within a fluvial sandstone-mudstone sequence of Late Triassic age in the western part of the Paris Basin, France. Two types of dolomites can be distinguished: (a) nodular dolomitic beds less than a few metres thick, which formed within mottled overbank siltstones and mudstones; and (b) massive dolomite up to 16 m thick, which occurs in coarse grained channel sandstones and conglomerates.The majority of the dolomite consists of a finely crystalline groundmass of dolomicrospar and, less commonly, dolomicrite. Glaebules, irregular spar-filled cracks, spheroidal dolomite, silicification and vuggy porosity are locally abundant in the massive dolomite. In contrast, biologically induced micromorphological features such as rhizocretions and alveolar-septal fabrics were observed in the thin, nodular dolomite beds.The dolomite is near stoichiometric, well ordered and non-ferroan. 18O values range from −7·7 to −0·4%o PDB and 18O values range from −5·1 to + 1·8%0 PDB and no obvious difference in the stable isotopic composition between both types of dolomites was observed. Sr isotope ratios range from 0·7101 to 0·7126 and are invariably higher than the contemporary Triassic sea water.A vadose—pedogenic origin for the thin dolocrete layers is indicated by the occurrence of rhizocretions and other biological structures. Several features, however, argue against a pedogenic origin for the massive carbonates, most notably the absence of biologically induced structures, the occurrence in coarse grained channel (and not overbank) deposits, and the great thickness. These units are thus interpreted as groundwater in origin. Phreatic calcretes of Quaternary age, widespread in inland Australia, are regarded as a modern analogue for the Triassic Paris Basin dolocretes.Petrographic observations argue in favour of primary (proto)dolomite precipitation, although early diagenetic replacement of calcite by (proto)dolomite cannot be ruled out. Strontium and carbon isotope data of early diagenetic dolocrete cements and oxygen isotope data of early diagenetic silica indicate an entirely non-marine, continental origin for the groundwaters. The poorly ordered and non-stoichiometric protodolomite probably underwent stabilization upon further burial resulting in a near-stoichiometric, well ordered dolomite that clearly lacks evidence for pervasive recrystallization.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 33 (1986), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Paleosols in the Lower Carboniferous limestones of South Wales commonly contain needle-fibre calcite which is an unusual form of calcite recently shown to form by the calcification of fungal hyphae in present day soils. The needle-fibre calcite occurs in two associations in the paleosols: as coatings on sediment grains and as rhizocretions. The former can be compared with the microbial grain coatings of Quaternary calcretes. The latter represent the sites of fungal coats on roots and are interpreted as probable ectomycorrhizae, a symbiotic fungal sheath-root association. These findings suggest that biomineralization was important in the formation of soil fabrics during the Carboniferous as it is in present day soils.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 30 (1983), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: A thin calcrete-crust horizon from the Lower Carboniferous Llanelly Formation of South Wales consists of two parts; an upper laminated unit and a lower peloidal unit. The former is interpreted as a subaerial stromatolite and the latter as an A horizon of a palaeosol. Comparisons are made with the A horizons of rendzinas and it is concluded that the calcrete-crust represents a complete rendzina profile. This fossil rendzina contains abundant evidence of a soil fauna in the form of fecal pellets and small burrows.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 33 (1986), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: During early Carboniferous times a major sea-level rise led to the development of an extensive carbonate ramp over what is now South Wales. Differential subsidence and sea-level changes resulted in distinctive facies sequences in the ramp succession and a model is offered which recognizes three distinct geomorpho-tectonic settings; inner, mid- and outer ramp. The inner ramp zone occurs in the more landward part of the province and was an area undergoing little or no subsidence. The sequence is dominated by oolitic grainstones and peritidal limestones representing shoal and back shoal environments. The peritidal units are transgressive deposits consisting of stacked asymmetrical shallowing-up cycles. The sequence contains many subaerial breaks and tectonic uplift resulted in base-level changes and fluvial incision. The mid-ramp zone sequence is intermediate in thickness between the inner and outer ramp successions and consists mainly of bioclastic limestones deposited below fairweather wave base. Sedimentation periodically exceeded sea-level rise and subsidence, and regressive (progradational) oolitic sand bodies developed, the thickest of which are stacked units with up to four individual sand bodies. Storm processes were of major importance in this setting. The outer ramp zone is represented by a thick sequence of muddy bioclastic limestones deposited below storm wave base and major Waulsortian reef-mounds also developed. None of the shallowing phases seen in the other ramp zones can be detected in this sequence. Subsidence and eustatic sea-level rise seem to have been the major controls on deposition but the recognition of eustatic sea-level falls is difficult. The detailed facies model for ramp carbonates presented here may be applicable elsewhere in the geological record.
    Type of Medium: Electronic Resource
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