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  • Sepsis  (6)
  • Trauma  (6)
  • Critically ill  (4)
  • Inorganic Chemistry  (3)
  • Malnutrition  (3)
  • 1
    ISSN: 1432-1440
    Keywords: Malnutrition ; HIV-infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Study objective: To determine forms of malnutrition and basal metabolism at different stages of immunological impairment in clinically stable patients infected with Human Immunodeficiency Virus (HIV).Design: Cross sectional study.Setting: 53 outpatients with HIV-infection classified according to the Walter Reed staging system (WR1 to WR6).Measurements and main results: 87% of the patients showed some evidence of malnutrition. Reduced body weight was found in 53%, 68% and 25% had decreases in fat and body cell mass, 17% had visceral protein deficiency, whereas extracellular mass and serum triglyceride concentrations were increased in 58% and 30%, respectively. Reduced serum albumin and transferrin closely paralleled immunological depression, whereas alterations in body composition were manifest early during HIV-infection (WR3) and remained unchanged during the transition to the Acquired Immune Deficiency Syndrome itself. Resting metabolic rate increased from WR1 to WR3; it remained within the expected range during later stages (WR4-WR6), but was not appropriately reduced in response to the loss in body cell mass.Conclusions: HIV-infected patients display both, calorie and protein malnutrition. Immunological depression was independent of loss of body mass, but was closely associated to decreases in serum albumin values. Nutritional assessment and intervention should therefore be performed at an early stage of HIV-infection.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 70 (1992), S. 478-486 
    ISSN: 1432-1440
    Keywords: Liver cirrhosis ; Liver transplantation ; Malnutrition ; Nutritional state ; Marasmus ; Kwashiorkor ; Nutritional assessment ; Liver function ; Energy expenditure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this article is to present detailed data on the nutritional assessment in cirrhotic patients. The exact frequency and types of malnutrition, its associations with the aetiology of liver disease, liver dysfunction and clinical staging in liver cirrhosis are unknown. A new classification system is presented which may help to suggest some interventional guidelines. Physical (anthropometry, 24-h urinary creatinine excretion, bioelectrical impedance analysis (BIA), total body potassium counting, ultrasound examination) and metabolic (indirect calorimetry) assessment of nutritional status was therefore performed in 123 patients with liver cirrhosis, who were considered as potential candidates for liver transplantation. Data were related to the clinical, biochemical, histological and prognostic data of liver disease. Of our patients 65% showed some signs of protein-calorie malnutrition as indicated by low body cell mass, reduced serum albumin concentrations or abnormal skinfold thickness. Of these 34% were considered as “kwashiorkor-like” (normal body composition, serum albumin 〈35 g/1), and 18% were “marastic” (reduced body weight, body cell mass, and fat mass). However, 49% of the malnourished group had reduced body cell mass in association with increased fat mass and frequently presented with a normal body weight (“mixed” or “obese” type). Protein-calorie malnutrition did not correlate with the aetiology of the disease and biochemical parameters of liver function. Malnutrition was observed at all clinical stages but was more frequently seen at advanced stages. We conclude that malnutrition associated with liver cirrhosis is not a clear phenomenon. Its clinical presentation is heterogenous and not reflected by the histological or biochemical parameters of liver disease. Since malnutrition is rarely diagnosed, early and detailed nutritional assessment in all patients with liver disease is important.
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  • 3
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Monitoring ; Pulmonalarterienkatheter ; Sv¯O2 ; kontinuierliche Herzzeitvolumenbestimmung ; Kosten ; kritisch Kranke ; Key words Pulmonary artery catheter ; Sv¯O2 ; Continuous cardiac output ; Costs ; Monitoring ; Critically ill ; Outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The introduction of flow-directed pulmonary artery (PA) catheters has helped to improve our knowledge of cardiovascular physiology. There have been several developments of this equipment in recent years, including continuous monitoring of mixed-venous O2 saturation (Sv¯O2) and cardiac output (CO). The high purchase price, however, is an obstacle to its use in the critically ill. The aim of the present study was to analyse the actual costs of these devices in comparison to standardly used intermittent monitoring of Sv¯O2 and CO. Methods. Thirty critically ill patients in a surgical intensive care unit (ICU) were prospectively studied. PA catheter monitoring was indicated by physicians who were not involved in the study. The patients were randomly allocated to one of the following groups: 1. a standard PA catheter was used, and Sv¯O2 and CO were intermittently measured 6 times a day on a routine basis and additionally when necessary from the clinical point of view; 2. Sv¯O2 was continuously measured using a fiberoptic PA catheter; and 3. CO was continuously monitored using a newly developed PA catheter. Costs for the catheter equipment and laboratory analyses (Sv¯O2) were calculated and the durations of intermittent monitoring techniques were measured. Costs for the `hardware' (monitor, blood gas analyser) were not taken into account. Sv¯O2 was measured by the ICU staff using an ICU-owned blood gas analyser (4.78 DM/analysis) and by a central laboratory unit, which had to be paid for its analyses (30.50 DM/analysis), respectively. Results. The groups were comparable with regard to their demographic data. A total of 378 intermittent measurements of Sv¯O2 and 449 mean CO measurements (1611 single bolus CO measurements) were carried out in the patients in whom a standard PA catheter was inserted. For daily calibration, a total of 50 single Sv¯O2 measurements were done in the group in which Sv¯O2 was continuously monitored. A total of 27.7 h were spent for intermittent Sv¯O2 measurements (time range of one analysis using the ICU-based blood gas analyser: 4.0 to 7.9 min); intermittent CO monitoring took a total of 14.2 h (time range of one mean CO measurement: 1.6 to 3.0 min). When blood gases were analysed by a central laboratory unit, costs for intermittent Sv¯O2 were tremendously higher than when monitored continuously. Conclusion. Monitoring devices that provide us with continuous information on the patient's state may have advantages in the management of the critically ill. Whether the patient's `outcome' can be improved by monitoring Sv¯O2 and CO continuously was not addressed by the present study. Instead, this study focused on the question of whether these devices are more cost-intensive than standard PA catheter monitoring systems. Costs for laboratory analyses can blunt the advantage of lower costs for the standard PA catheter. Intermittent (standard) monitoring of Sv¯O2 and CO was significantly more time-consuming than the continuous methods. It can be summarised that although purchase costs for the more advanced PA catheters are higher than for standard PA catheters, the use of these continuous monitoring devices in the critically ill can be justified from a financial point of view.
    Notes: Zusammenfassung 30 Patienten einer operativen Intensivstation, bei denen die Indikation eines erweiterten hämodynamischen Monitorings mittels Pulmonalarterien (PA-) Katheters gestellt worden war, wurden prospektiv untersucht. Randomisiert wurde folgende Gruppeneinteilung vorgenommen (10 Patienten pro Gruppe): 1. Ein Standard-PA-Katheter wurde eingesetzt, und die gemischt-venöse Sauerstoffsättigung (Sv¯O 2 ) sowie das Herzzeitvolumen (HZV) wurden routinemäßig 6mal am Tag und bei Bedarf zusätzlich bestimmt, 2. die Sv¯O 2 wurde kontinuierlich mit Hilfe eines Fiberoptikkatheters erfaßt und 3. das HZV wurde mit Hilfe eines neuentwickelten PA-Katheters kontinuierlich überwacht. Die Kosten für Einmalmaterialien und Laborkosten sowie der Zeitaufwand bei den intermittierenden Meßverfahren wurden über einen Zeitraum von 5 Tagen erfaßt. Neben den Kosten für die vom eigenen Pflegepersonal durchgeführten Blutgasanalysen mit Hilfe eines eigenen Blutgasanalysators wurde zusätzlich der Kostenanfall bei ,Fremd`bestimmung der Blutgasanalysen (durch das Zentrallabor) berechnet. Insgesamt wurden 378 Bestimmungen der Sv¯O 2 durchgeführt und 449 mittlere HZV-Werte erfaßt. Ohne Berücksichtigung des Zeitaufwands lagen die Kosten pro Patient bei der kontinuierlichen HZV-Bestimmung am höchsten. Bei der intermittierenden Sv¯O 2 -Bestimmung zeigte sich bei Einsatz des intensiveigenen Blutgasanalysegeräts eine Differenz von ca. 22,– DM/Tag zur kontinuierlichen Methode. Bei ,Fremd`bestimmung findet sich bei dem kontinuierlichen Verfahren ein deutlicher Vorteil. Zusammenfassend läßt sich feststellen, daß kontinuierliche Verfahren zur Überwachung kritisch Kranker von Vorteil erscheinen. Die höheren Kosten für die weiterentwickelten PA-Katheter wurden teilweise durch den Wegfall von Zusatzkosten, die bei den intermittierenden Verfahren entstehen, ausgeglichen. Der Wert einer deutlichen Entlastung des Intensivpersonals ist schwer abschätzbar, läßt aber den Einsatz dieser Verfahren als sinnvoll erscheinen.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 1075-1081 
    ISSN: 1432-1238
    Keywords: Key words Critically ill ; Sepsis ; Trauma ; Volume therapy ; Platelet function ; Aggregometry ; Hydroxyethyl starch solution ; Albumin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Both albumin and synthetic colloids such as hydroxyethyl starch (HES) solution are used to optimize hemodynamics in the critically ill. The influence of different long-term infusion regimes on platelet function was studied. Design: Prospective, randomized study. Setting: Clinical investigation on a university hospital surgical intensive care unit. Patients: Twenty-eight consecutive trauma patients (injury severity score〉15 points) and 28 consecutive nontraumatized surgical patients with sepsis. Interventions: The patients received either 20% human albumin (HA trauma, n=14; HA sepsis, n=14) or 10% low-molecular-weight HES solution HES 200/0.5 (HES trauma, n=14; HES sepsis; n=14) for 5 days to maintain central venous pressure and/or pulmonary capillary wedge pressure between 12 and 16 mmHg. Measurements and results: Platelet function was assessed by aggregometry (=turbidimetric technique) using adenosine diphosphate 2.0 μmol/l, collagen 4 μl/ml, and epinephrine 25 μmol/l as inductors. Arterial blood was sampled on the day of admission or the day of diagnosis of sepsis (=baseline value) and over the next 5 days. Standard coagulation parameters (antithrombin III, fibrinogen, partial thromboplastin time) were also measured. Total use of HES by the 5th day totalled 4870±990 ml in the trauma and 3260±790 ml in the sepsis patients (HA trauma: 1850±380 ml; HA sepsis: 1790±400 ml). Maximum platelet aggregation decreased significantly during the first 2–3 days after baseline in all groups. At the end of the investigation period, platelet aggregation variables had recovered and reached (or even exceeded) baseline values. Within the entire investigation period, the course of platelet aggregation variables did not differ significantly between HA and HES-treated patients irrespective of whether they were trauma or sepsis patients. Conclusions: Alterations in hemostasis may occur for several reasons in the critically ill. Human albumin is the preferred first-line volume therapy in patients at risk for coagulation disorders. With respect to platelet function, volume replacement with (lower-priced) low-molecular-weight HES solutions can be recommended in this situation without any risk.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 1075-1081 
    ISSN: 1432-1238
    Keywords: Critically ill ; Sepsis ; Trauma ; Volume therapy ; Platelet function ; Aggregometry ; Hydroxyethyl starch solution ; Albumin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Both albumin and synthetic colloids such as hydroxyethyl starch (HES) solution are used to optimize hemodynamics in the critically ill. The influence of different long-term infusion regimes on platelet function was studied. Design Prospective, randomized study. Setting Clinical investigation on a university hospital surgical intensive care unit. Patients Twenty-eight consecutive trauma patients (injury severity score〉15 points) and 28 consecutive nontraumatized surgical patients with sepsis. Interventions The patients received either 20% human albumin (HA trauma,n=14; HA sepsis,n=14) or 10% low-molecular-weight HES solution HES 200/0.5 (HES trauma,n=14; HES sepsis;n=14) for 5 days to maintain central venous pressure and/or pulmonary capillary wedge pressure between 12 and 16 mmHg. Measurements and results Platelet function was assessed by aggregometry (=turbidimetric technique) using adenosine diphosphate 2.0 μmol/l, collagen 4 μl/ml, and epinephrine 25 μmol/l as inductors. Arterial blood was sampled on the day of admission or the day of diagnosis of sepsis (=baseline value) and over the next 5 days. Standard coagulation parameters (antithrombin III, fibrinogen, partial thromboplastin time) were also measured. Total use of HES by the 5th day totalled 4870±990 ml in the trauma and 3260±790 ml in the sepsis patients (HA trauma: 1850±380 ml; HA sepsis: 1790±400 ml). Maximum platelet aggregation decreased significantly during the first 2–3 days after baseline in all groups. At the end of the investigation period, platelet aggregation variables had recovered and reached (or even exceeded) baseline values. Within the entire investigation period, the course of platelet aggregation variables did not differ significantly between HA and HES-treated patients irrespective of whether they were trauma or sepsis patients. Conclusions Alterations in hemostasis may occur for several reasons in the critically ill. Human albumin is the preferred first-line volume therapy in patients at risk for coagulation disorders. With respect to platelet function, volume replacement with (lower-priced) low-molecular-weight HES solutions can be recommended in this situation without any risk.
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  • 6
    ISSN: 1432-1238
    Keywords: Key words Pentoxifylline ; Critically ill ; Sepsis ; Trauma ; Inflammation ; Coagulation ; Platelet function ; Aggregometry ; Collagen ; Epinephrine ; Adenosine diphosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The methylxanthine derivative pentoxifylline (PTX) is one of those promising substances which are under current investigation to modify or limit inflammatory response. Antiaggregation activity has also been described that may contribute to the beneficial effects of this substance. Long-term effects on platelet function have not been elucidated yet. Design: Prospective, randomized study. Setting: Clinical investigation on a surgical intensive care unit of a university hospital. Patients: 26 trauma patients and 26 patients suffering from sepsis secondary to major operations were consecutively studied. Interventions: The patients prospectively received either 1.5 mg/kg per h pentoxifylline continuously for 5 days (after a loading dose of 600 mg) (trauma-PTX, n=13; sepsis-PTX, n=13) or saline solution as placebo (trauma-control; n=13; sepsis-control, n=13). Measurements: On the day of admission (trauma patients) or day of the diagnosis of sepsis and at 12:00 p.m. during the next 5 days, platelet aggregation induced by adenosine diphosphate (ADP 2.0 μmol/l), collagen (4 μl/ml), and epinephrine (25 μmol/l) was determined by a turbidimetric method from arterial blood samples. Standard coagulation screen was also monitored. Main results: In untreated trauma and sepsis patients, maximum platelet aggregation induced by all three agonists decreased during the first few days after inclusion in the study [trauma: ADP–17.1±8.0 rel% (% change from baseline); sepsis: ADP –26.1±5.6 rel%]. In due course, maximum platelet aggregation recovered, reaching the baseline value or even exceeding it (trauma patients). In the PTX-treated patients, platelet aggregation was significantly less impaired (sepsis group: ADP –4.4±3.3 rel%) or even increased beyond baseline values in the first few days of the study (trauma group: ADP 16.1±8.0 rel%). Fibrinogen plasma levels were lower in the non-treated control groups (p〈0.05) than in the PTX groups. Conclusions: Continuous infusion of PTX for 5 days did not impair platelet function in critically ill patients. In both trauma and sepsis patients, the usual deterioration in platelet function was even attenuated, which may be due to the effects of PTX on cytokine release (e.g., reduction in tumor necrosis factor and interleukin-1), improvement in microcirculation, or additional fibrinolytic effects.
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  • 7
    ISSN: 1432-1238
    Keywords: Pentoxifylline ; Critically ill ; Sepsis ; Trauma ; Inflammation ; Coagulation ; Platelet function ; Aggregometry ; Collagen ; Epinephrine ; Adenosine diphosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective The methylxanthine derivative pentoxifylline (PTX) is one of those promising substances which are under current investigation to modify or limit inflammatory response. Antiaggregation activity has also been described that may contribute to the beneficial effects of this substance. Long-term effects on platelet function have not been elucidated yet. Design Prospective, randomized study. Setting Clinical investigation on a surgical intensive care unit of a university hospital. Patients 26 trauma patients and 26 patients suffering from sepsis secondary to major operations were consecutively studied. Interventions The patients prospectively received either 1.5 mg/kg per h pentoxifylline continuously for 5 days (after a loading dose of 600 mg) (trauma-PTX,n=13; sepsis-PTX,n=13) or saline solution as placebo (trauma-control;n=13; sepsis-control,n=13). Measurements On the day of admission (trauma patients) or day of the diagnosis of sepsis and at 12:00 p.m. during the next 5 days, platelet aggregation induced by adenosine diphosphate (ADP 2.0 μmol/l), collagen (4 μl/ml), and epinephrine (25 μmol/l) was determined by a turbidimetric method from arterial blood samples. Standard coagulation screen was also monitored. Main results In untreated trauma and sepsis patients, maximum platelet aggregation induced by all three agonists decreased during the first few days after inclusion in the study [trauma: ADP −17.1±8.0 rel% (% change from baseline); sepsis: ADP −26.1±5.6 rel%]. In due course, maximum platelet aggregation recovered, reaching the baseline value or even exceeding it (trauma patients). In the PTX-treated patients, platelet aggregation was significantly less impaired (sepsis group: ADP −4.4±3.3 rel%) or even increased beyond baseline values in the first few days of the study (trauma group: ADP 16.1±8.0 rel%). Fibrinogen plasma levels were lower in the non-treated control groups (p〈0.05) than in the PTX groups. Conclusions Continuous infusion of PTX for 5 days did not impair platelet function in critically ill patients. In both trauma and sepsis patients, the usual deterioration in platelet function was even attenuated, which may be due to the effects of PTX on cytokine release (e.g., reduction in tumor necrosis factor and interleukin-1), improvement in microcirculation, or additional fibrinolytic effects.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 23 (1997), S. 567-573 
    ISSN: 1432-1238
    Keywords: Key words Critically ill ; Sepsis ; Trauma ; Neurosurgery ; Heparin ; Anticoagulation ; Platelet function ; Aggregometry ; Adenosine diphosphate ; Epinephrine ; Collagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To study the influence of continuous administration of heparin on platelet function in intensive care patients. Design: Prospective, serial investigation. Setting: Clinical investigation on a surgical and neurosurgical intensive care unit in a university hospital. Patients: The study included 45 patients: 15 postoperative with patients sepsis (Acute Physiology and Chronic Health Evaluation II score between 15 and 25), 15 trauma patients (Injury Severity Score 15 to 25), and 15 neurosurgical patients. Interventions: Management of the patients was carried out according to the guidelines for modern intensive care therapy. Sepsis and trauma patients received standard (unfractionated) heparin continuously [aim: an activated partial thromboplastin time (aPTT) approximately 2.0 times normal value; sepsis-heparin and trauma-heparin patients], whereas neurosurgical patients received no heparin (neurosurgical patients). Measurements and results: From arterial blood samples, platelet aggregation was measured by the turbidimetric method. Platelet aggregation was induced by adenosine diphosphate (ADP; 2.0 μmol/l), collagen (10 μg/ml), and epinephrine (25 μmol/l). Measurements were carried out on the day of diagnosis of sepsis or 12 h after hemodynamic stabilization (trauma and neurosurgery patients) (baseline) and during the next 5 days at 12.00 noon. Standard coagulation parameters [platelet count and fibrinogen and antithrombin III (AT III) plasma concentrations] were also monitored. Heparin 4–10 U/kg per h (mean dose: approximately 500 U/h) was necessary to reach an aPTT of about 2.0 times normal. Platelet count was highest in the neurosurgical patients, but it did not decrease after heparin administration to the trauma and sepsis patients. AT III and fibrinogen plasma levels were similar in the three groups of patients. In the sepsis group, platelet aggregation variables decreased significantly (e. g., epinephrine-induced maximum platelet aggregation: − 45 relative % from baseline value). Platelet function recovered during the study and even exceeded baseline values (e. g., ADP-induced maximum platelet aggregation: + 42.5 relative % from baseline value). Continuous heparinization did not blunt this increase of platelet aggregation variables. In the heparinized trauma patients, platelet aggregation variables remained almost stable and were no different to platelet aggregation data in the untreated neurosurgical patients. Conclusions: Continuous administration of heparin with an average dose of approximately 500 U/h did not negatively influence platelet function in the trauma patients. Recovery from reduced platelet function in the sepsis group was not affected by continuous heparinization. Thus, continuous heparinization with this dose appears to be safe with regard to platelet function in the intensive care patient.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 24 (1998), S. 28-36 
    ISSN: 1432-1238
    Keywords: Key words Critically ill ; Sepsis ; Trauma ; Volume therapy ; Albumin ; Hydroxyethylstarch solution ; Macrocirculation ; Microcirculation ; Pulmonary function ; Renal ; function ; Coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: There are still several concerns about the extensive and prolonged use of hydroxyethylstarch solution (HES) in critically ill patients. The effects of volume replacement with HES over 5 days on hemodynamics, laboratory data, and organ function were compared with volume therapy using human albumin (HA). Design: Prospective, randomized study. Setting: Clinical investigations on a surgical intensive care unit (ICU) of a university hospital. Patients: 150 traumatized patients (injury severity score 〉 15) and 150 postoperative patients with sepsis were analyzed. Interventions: Either 10 % low-molecular weight HES (HES-trauma, n = 75; HES-sepsis, n = 75) or 20 % HA (HA-trauma, n = 75; HA-sepsis, n = 75) was given for 5 days to maintain the pulmonary capillary wedge pressure (PCWP) between 12 and 15 torr. The entire management of therapy of the patients was performed by physicians who were not involved in the study and blinded to the infusion regimen. Measurements and results: In addition to extensive cardiorespiratory monitoring, several routine laboratory parameters for assessing pulmonary, renal, hepatic, and coagulation function were analyzed from arterial blood samples on the day of admission to the ICU and on the day of sepsis diagnosis, respectively (“baseline” value) and daily over the following 5 days. Mortality during and after the study did not differ significantly between the infusion groups. There were also no differences between the incidence of pulmonary, renal, or hepatic failure in the two subgroups. Mean arterial pressure, heart rate, and PCWP were similar in both subgroups, whereas cardiac index, oxygen delivery index, oxygen consumption index, and the ratio between the partial pressure of oxygen in arterial blood and fractional inspired oxygen were higher in the HES- than in the HA-treated groups. Standard coagulation parameters did not differ, albumin concentration increased significantly in both HA groups, and lactate concentrations decreased only in the HES-sepsis patients (from 2.8 ± 0.5 to 1.5 ± 0.4 mg/dl). Volume replacement using albumin was significantly (p 〈 0.001) more costly than therapy with HES. Conclusions: Volume therapy with 10 % HES for 5 days in the ICU patient showed no disadvantages compared with an infusion regimen using 20 % albumin. Volume replacement using HES may even be associated with improved hemodynamics. HES appears to be a valuable and significantly cheaper alternative to albumin – even for prolonged volume therapy in the critically ill patient.
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  • 10
    ISSN: 1435-2451
    Keywords: Esophageal carcinoma ; Gastric carcinomaCancer cachexia ; Malnutrition ; Body composition ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Frage des Einflusses des präoperativen Gewichtsverlusts auf die metabolische Adaptation an das Operationstrauma und auf die Häufigkeit postoperativer Komplikationen wurden 44 Patienten mit Karzinomen des oberen Gastrointestinaltrakts (23 Ösophagus-und 21 Magenkarzinome) 10–14 Tage prä- und postoperativ im Ernährungsstatus, der Körperzusammensetzung und der Stoffwechsellage untersucht. Die Patienten wurden entsprechend dem präoperativen Gewichtsverlust in den letzten 6 Monaten vor der stationären Aufnahme in 3 Gruppen unterteilt: I: Abnahme um 0–5% des Ausgangsgewichts, II: 5–10% und III: 〉 10%. 50% der Patienten wiesen präoperativ keinen oder nur einen geringen Gewichtsverlust auf. Auch bei hohem Gewichtsverlust wurde das jeweils errechnete ideale Körpergewicht nicht unterschritten. Körperzellund Fettmasse waren in Gruppe III signifikant (p 〈 0,05) niedriger als in Gruppe I. Da der Ruheenergieverbrauch bei den meisten Patienten nicht erhöht war, müssen als Ursache des Gewichtsverlusts Tumorstenose und Dysphagie, jedoch nicht ein Hypermetabolismus, angesehen werden. Mehr als 50% des Energiebedarfs wurden durch Lipidoxidation gedeckt. Insgesamt erfüllten selbst die Patienten in Gruppe III nicht die Kriterien einer Mangelernährung. Der perioperative Gewichtsverlust war in der Gruppe III am niedrigsten (1,6 ± 4,9 kg) im Vergleich zu den Gruppen I und II mit 2,9 ± 1,7 bzw. 5,0 ± 6,9 kg. In allen Gruppen wurde eine Erhöhung des Energieverbrauchs und der Fettoxidationsrate, einhergehend mit einer Hemmung der Glukoseoxidation, beobachtet. Dies resultierte in einer Verminderung der Körperzellmasse. Unabhängig vom präoperativen Gewichtsverlust kam es bei 8 Patienten zu schwerwiegenden Komplikationen mit Pneumonie in 6 und Anastomoseninsuffizienz in 2 Fällen. Kein Patient verstarb. Die metabolische Reaktion auf das Operationstrauma ist auch bei Patienten mit ausgeprägtem präoperativem Gewichtsverlust adäquat. Diese Patienten bleiben kompensiert und der präoperative Gewichtsverlust ist ohne signifikanten Einfluß auf die postoperative Komplikationsrate.
    Notes: Summary Body composition and energy expenditure were investigated before and 10–14 days after surgery in 44 patients with upper gastrointestinal cancer (23 esophageal and 21 gastric cancer) in order to assess the impact of preoperative weight loss on metabolic adaptation to the surgical trauma and on postoperative complications. Patients were divided in three groups with I: 0–5%, II: 5–10% and III: 〉 10% preoperative weight loss related to the usual body weight. 50% of the patients presented with no or just minor weight loss. Even in case of weight loss 〉 10% no decrease below the ideal body weight was observed. Body cell mass and fat mass were significantly (p 〈 0.05) reduced in group III when compared with I. Since energy expenditure and substrate oxidation rates were rather normal in most patients weight loss was considered to be due to tumor related stenosis and dysphagia. More than 50% of the energy requirements were gained from fat oxidation. General criteria of malnutrition were not fulfilled. Perioperative weight loss was lowest (1.6 ± 4.9 kg) in patients of group III related to group I (2.9 ± 1.7 kg) and II (5.0 ± 6.9 kg). Similar elevation of energy expenditure and lipid oxidation with concomitant reduction in glucose oxidation was observed in all groups of patients. This led to a similar decrease of body cell mass. Independant of preoperative weight loss major complications occurred in 8 cases — pneumonia in 6 and leakage of the anastomosis in 2 patients; no patient died. From this study can be concluded that with regard to perioperative weight loss the metabolic response to surgical trauma is adequate even in patients with marked preoperative weight loss. These patients remain compensated and preoperative weight loss is without major effect on postoperative complication rate.
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