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  • instrumentation  (2)
  • Delayed-radiation damage  (1)
  • Hirnstimulation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 121 (1993), S. 82-85 
    ISSN: 0942-0940
    Keywords: Stereotactic surgery ; magnetic resonance imaging ; radiosurgery ; treatment planning ; instrumentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Magnetic Resonance has become the preferred neuro-imaging modality. To fully take advantage of the high anatomical resolution the Riechert stereotactic system was adapted for use in Magnetic Resonance Stereotaxy. The head ring which until recently was made of an aluminum alloy has been replaced by an unsegmented head ring of pure titanium without changing the dimensions and fixation mode. No significant misregistration due to eddy currents has been noticed. Minor distortion induced by the titanium head ring can be corrected mathematically. Thus the geometric information is limited only by the pixel resolution of the MR image.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 94 (1988), S. 88-92 
    ISSN: 0942-0940
    Keywords: Stereotaxy ; brain tumour ; combined open-stereotaxic procedure ; instrumentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The combined use of Stereotaxic and microsurgical techniques makes it possible to minimize damage to critical nervous tissue during operations in subcortical regions. The Riechert Stereotaxic system has been further modified. The patient's head is fixed in the new head ring with standard Mayfield pins. The headring is connected to a standard Mayfield clamp at symmetrical bearings at 0, 90, 180, and 270 degrees, which holds the head stable in any desired position and allows unhindered access to the cranial vault and skull base.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 70 (1986), S. 91-102 
    ISSN: 1432-0533
    Keywords: Iridium-192 ; Interstitial radiation ; Brachytherapy ; Radionecrosis ; Delayed-radiation damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the effects of a permanent interstitial source of γ-irradiation on normal brain tissue, single iridium-192 (Ir-192) wires (1.05 mCi) were stereotactically implanted into the left centrum semiovale of adult dogs (survival times, 25, 46, 74, 230 and 362 days). Within 25 days, a coagulation necrosis developed in the immediate vicinity of the radioactive source. In later stages, the necrosis increased in size and became progressively mineralized. Staining for extravascular immunoreactive serum proteins revealed the presence of a chronic perifocal vasogenic edema, which extended into the white matter of the entire ipsilateral hemisphere. This edema persisted through all stages and showed a significant decrease only in the animal with a 1-year survival. A reactive gliosis with formation of a dense network of glial fibrillary acidic protein-positive astrocytes developed around the central necrosis in the adjacent white matter and, at later stages, in the contralateral hemisphere. Demyelination was restricted to the ipsilateral centrum semiovale without affecting the internal capsule or the contralateral hemisphere. It was present as early as 25 days and showed no tendency to increase at later stages. Analysis of the sequential morphological changes following Ir-192 implantation suggests that the central coagulation necrosis represents a direct radiation effect, the sharp focal delineation of which can be explained by the physical characteristics of the radiation source, i.e., rapid falloff of the dose at short distances. Due to the continuous emission of radiation energy, there is a perifocal zone with overlapping of progressive radiation damage and tissue organization. This focus becomes the source of a chronic vasogenic edema, which in turn is most likely to be responsible for the partial demyelination of the adjacent centrum semiovale. The widespread reactive gliosis observed at all stages may also, in part, be a consequence of chronic vasogenic edema, but its distribution suggests that direct radiation effects may also be involved.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Nervenarzt 68 (1997), S. 477-484 
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Bewegungsstörungen ; M. Parkinson ; Stereotaxie ; Tremor ; Hirnstimulation ; Key words Stereotactic surgery ; Parkinson’s disease ; Movement disorders ; Thalamotomy ; Pallidotomy ; Brain ; Stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Stereotactic surgery for movement disorders is currently undergoing a re-evaluation. A new understanding of the pathophysiology makes the surgical lesion a logical step for the aleviation of both hyperkinetic symptoms such as tremor and hypokinetic symptoms like bradykinesia. Advances in imaging and electrophysiological control render these procedures more accurate and safer. Indications are medically refractory, Parkinsonean tremor, essential tremor, cerebellar tremor, bradykinesia and L-Dopa induced dyskinesis. The standard procedure is ablative surgery, i.e. thalamotomy for tremors and pallidotomy for bradykinesia, dystonia and L-Dopa induced dyskinesias. Deep brain stimulation is a novel alternative for selected patients which is currently evaluated. Neural transplantation of autologus, fetal or genetically manipulated cell suspensions into the striatum for the time being is experimental.
    Notes: Zusammenfassung Die chirurgische, d.h. stereotaktische Behandlung von Bewegungsstörungen erfährt derzeit eine Neubewertung. Neue Einsichten in die Pathophysiologie der Bewegungsstörungen haben dazu geführt, daß der stereotaktische Eingriff als begründeter therapeutischer Schritt angesehen wird. Die Nebenwirkungen stereotaktischer Eingriffe sind durch neue operative Techniken, digitale Bildgebung und elektrophysiologische Kontrollen geringer geworden. Die hauptsächlichen Indikationen sind Parkinson-Tremor und Rigidität, essentieller Tremor und zerebellärer Tremor. Als etablierte Routinemethode wird die stereotaktische Elektrokoagulation im Thalamus für alle Tremorformen weiterhin bevorzugt. Für die Behandlung von Akinesie und Bradykinesie, besonders auch der Dopa-induzierten Hyperkinesien, gewinnt die Pallidotomie rasch wieder an Bedeutung. Die chronische Stimulation durch Implantation von Hirnelektroden ist in Einzelfällen indiziert. Die Transplantation autologer, fetaler oder gentechnisch manipulierter Zellen wird derzeit in ihrer Bedeutung für die Therapie untersucht.
    Type of Medium: Electronic Resource
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