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  • Demenzausprägung  (1)
  • Diabetic renal lesion  (1)
  • Immunocytochemistry  (1)
  • 1
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Alzheimer-Erkrankung ; Visuokonstruktive Störung ; Zeichnen ; Demenzausprägung ; Key words Alzheimer’s disease ; Visuo-constructive impairment ; Drawing ; Severity of dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In this study we assessed the drawing abilities in 37 patients with probable Alzheimer’s disease according to NINCDS-ADRDA criteria. Drawing abilities (drawing: house, flower, clock; Rey-Osterrieth figure; copying: MMST-figure; Rey-Osterrieth figure) were quantified with different rating schemes and related to other neuropsychological assessments. All patients underwent a positron emission tomography with 18-FDG. Drawing performance was highly correlated with severity of dementia – expressed in MMST scores (r=0.78; p〈0.0001) – with visuo-spatial short-term memory (r=–0.69; p=0.001), and writing abilities (r=–0.77; p〈0.0001). The summarized drawing score showed a statistically significant correlation with the rate of temporoparietal glucose metabolism measured with positron emission tomography and 18-FDG (r=0.39; p=0.017). In the drawings of AD patients omittings and simplifications were typical, whereas perseverations rarely occured. In severely demented patients closing-in phenomenons could be de- scribed, too. A subgroup of AD patients with visuo-constructive impairment as the leading symptom could not be identified.
    Notes: Zusammenfassung Bei 37 Patienten mit der wahrscheinlichen Alzheimer-Erkrankung (AD) nach NINCDS-ADRDA-Kriterien wurden die Zeichenleistungen (freies Zeichnen: Haus, Blume, Uhr; Rey-Osterrieth-Figur; Abzeichnen: MMST-Figur; Rey-Osterrieth Figur) untersucht und mit anderen neuropsychologischen Tests verglichen. Bei allen Patienten wurde weiterhin eine Positronen-Emissions-Tomographie mit 18-FDG durchgeführt. Die Zeichenleistungen der Patienten waren hoch mit der Demenzausprägung, ausgedrückt in MMST-Werten, korreliert (r=0,78; p〈0,0001) und wiesen einen engen Zusammenhang zur visuospatialen Kurzzeitgedächtnisspanne (r=–0,69; p=0,001) und zur Schreibleistung (r=–0,77; p〈0,0001) auf. Der summierte Zeichenscore wies einen statistisch signifikanten Zusammenhang mit der temporoparietalen Stoffwechselrate – gemessen mit PET und FDG – auf (r=0,39; p=0,017). Bei den Zeichnungen der AD-Patienten zeigten sich v.a. Auslassungen und Vereinfachungen. Perseverationen kamen selten vor. Bei schwer dementen Patienten ließen sich auch Closing-in-Phänomene beobachten. Eine Subgruppe von AD-Patienten, bei denen visuokonstruktive Störungen die Leitsymptomatik ihrer Demenz waren, ließ sich nicht identifizieren.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Aluminum ; Rabbit ; Immunocytochemistry ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Exposure of the central nervous system (CNS) of rabbits to aluminum salts produces a progressive encephalopathy. Examination of CNS strucres discloses widespread perikaryal neurofibrillary tangle (NFTs) formation. The aluminum-induced NFTs consist of collections of normal neurofilaments, and differ ultrastructurally and in their solubility characteristics from Alzheimer-type NFTs, the latter being composed of largely insoluble paired helical filaments. The present study compares NFTs found in the rabbit to those of Alzheimer's disease, using monoclonal antibodies (SMI 31, SMI 32) that recognize phosphorylated and non-phosphorylated determinants respectively in normal neurofilaments, and an antiserum raised against purified microtubules. Paraffin-embedded sections were stained by the avidin-biotin immunocytochemical method. Intense staining of aluminum-induced NFTs was found after processing with SMI 31 and SMI 32, while no staining of non-tangled perikarya of control rabbits or of Alzheimer-type NFTs was seen. Antimicrotubule antiserum gave weak, nonfocal staining in the aluminum-treated and control rabbits, while Alzheimer-type NFTs were stained intensely. These results show that phosphorylated and non-phosphorylated neurofilaments accumulate in aluminum-induced NFTs, thus complementing the previously demonstrated specific slowing of the axonal transport of neurofilaments in aluminum intoxication. Further, they suggest that the presence of microtubular proteins may be necessary for altered neurofilaments to take on a paired helical configuration.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 9 (1973), S. 203-209 
    ISSN: 1432-0428
    Keywords: Encephalomyocarditis virus ; Virus-induced diabetes ; Diabetic renal lesion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Encephalomyocarditis (EMC) virus infected DBA/2 mice develop a diabetes mellitus-like disease. Many animals survive the acute viral infection and exhibit hyperglycemia and glycosuria for varying periods thereafter. Accumulations of homogeneous, electron dense, basement membrane-like material are observed in the mesangium of the glomerulus of these animals as early as three months after inoculation. The peripheral capillary basement membranes are not affected. Since the alterations are not found in uninfected animals, it is assumed that the abnormal metabolic state or the virus infection, or both processes, are responsible for the glomerular changes. Further investigation will be required to elucidate the pathogenesis of this obscure lesion.
    Type of Medium: Electronic Resource
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