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  • 1
    Digitale Medien
    Digitale Medien
    Effect of ascariasis and its treatment on drug absorption (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 217-219 
    Details
    ISSN: 1432-1041
    Schlagwort(e): ascaris ; isoniazid ; sulphadimidine ; drug absorption
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Ascariasis has been reported to impair the absorption of nutrients, vitamin A, and D-xylose, which is corrected on treatment. The effect of ascariasis and its treatment on the absorption of sulphadimidine and isoniazid has been investigated. There was no difference between drug absorption before and after the treatment or in comparison with a normal population.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00614563
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of iron deficiency anaemia and its treatment on sulphadimidine absorption (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 323-325 
    Details
    ISSN: 1432-1041
    Schlagwort(e): iron deficiency anaemia ; sulphadimidine ; absorption ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of iron deficiency anaemia and its treatment on the absorption of sulphadimidine has been investigated in adult patients. The absorption judged by total % of the dose excreted in urine and Cmax, tmax, AUC and Kabs in plasma, was not significantly different before and after iron therapy or correction of anaemia. However, sulphadimidine absorption by the anaemic patients was significantly greater than in normals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00637571
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  • 3
    Digitale Medien
    Digitale Medien
    Bioinequivalence of marketed diltiazem preparations (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 189-190 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Diltiazem ; bioinequivalence ; plasma concentration ; dissolution ; pharmacokinetics ; commercial brands
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A bioequivalence study of three brands of regular diltiazem — Angizem (A), Dilzem (B) and Herbesser (C) has been carried out in 5 healthy, male volunteers. After a single oral dose of 60 mg of each preparation, the mean AUC(0–8 h) and Cmax of preparation B was significantly higher than of brands A and C. The tmax of A and B was significantly lower than of C. B had a higher dissolution rate in vitro (98.8% dissolved in 45 min) than A and C. Thus, there was bioinequivalence of the three brands of diltiazem, due partly to differences in dissolution and perhaps in part to a first pass effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00280058
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  • 4
    Digitale Medien
    Digitale Medien
    Successful treatment of disseminated candidiasis resistant to amphotericin B by liposomal amphotericin B: a case report (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 569-571 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Acute lymphoblastic leukaemia ; Chronic disseminated candidiasis ; Amphotericin B ; Small unilamellar liposomes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The case of a female patient with acute lymphoblastic leukaemia and chronic disseminated candidiasis, who was refractory to 1.8 g conventional amphotericin B therapy, is reported. She experienced severe amphotericin-B-related side-effects in spite of pretreatment, but was subsequently successfully treated with 3 g of a small unilamellar liposome formulation of amphotericin B prepared from soya phosphatidylcholine and cholesterol in a 7∶3 molar ratio at our institute. The patient experienced minimal side-effects with this preparation, although no pretreatment was given. Liposomal amphotericin B prepared in our institute appears to be a safe and effective therapy for systemic fungal infections. However, large controlled studies are required to determine more precisely the potential of liposomal amphotericin B in the treatment of severe systemic fungal infection.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01372718
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