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  • 1
    Electronic Resource
    Electronic Resource
    Plasma dopamine-β-hydroxylase activity and the pressor effect of dopamine infusion in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 197-200 
    Details
    ISSN: 1432-1041
    Keywords: Dopamine-β-hydroxylase ; dopamine infusion ; blood pressure ; plasma ; man ; inter-individual variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to study the function of dopamine-β-hydroxylase (DBH) in human plasma, dopamine, its natural substrate, was infused intravenously in 22 healthy volunteers. Their plasma DBH activities showed great interindividual variations (31–301 units/ml). The infusion rates of dopamine required to increase systolic blood pressure (BP) by 30 mm Hg differed considerably between the subjects, and ranged from 3,0 to 11,6 µg/kg/min. No correlation could be shown between the various dopamine doses and individual plasma levels of DBH. It was concluded, therefore, that plasma DBH in the blood stream was enzymatically inactive. Experiments with human plasma DBH in vitro also support this interpretation. Consequently, interindividual differences in the effects on BP during dopamine infusion cannot be due to pressor effects of noradrenaline synthesized by plasma DBH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558329
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of nitrendipine in terminal renal failure (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 467-471 
    Details
    ISSN: 1432-1041
    Keywords: nitrendipine ; renal failure ; pharmacokinetics ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and plasma protein binding of nitrendipine in patients with terminal renal failure have been compared with those in subjects with normal renal function. Kinetic parameters were calculated after a single 40 mg oral dose, an i.v. injection of 3 mg and after a 15 mg i.v. infusion of nitrendipine. Steady-state plasma levels were determined after 5 days of oral treatment with 20 mg b.d. Pharmacokinetic parameters and steady-state plasma levels in patients with renal failure did not differ from those in subjects with normal renal function. Nitrendipine was as highly bound to plasma proteins in patients with renal failure, as in subjects with normal renal function. The plasma protein did not differ between the two. The dosage of nitrendipine need not be modified for kinetic reasons in patients with renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558071
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Total and free steady-state plasma levels and pharmacokinetics of nifedipine in patients with terminal renal failure (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 185-189 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; renal failure ; pharmacokinetics ; protein binding ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The total and free steady-state plasma levels of nifedipine in patients with renal failure have been compared with those in subjects with normal renal function. Studies were done after administration of nifedipine 10 mg t.d.s. p.o. for 5 days, after i.v. infusion of 4·4 mg, and after a single 10 mg oral dose. The systemic clearance of nifedipine after a single i.v.-dose was higher in subjects with renal insufficiency (854 ml/min) than in those with normal renal function (468 ml/min). After the single oral dose the AUC (6100 ng·min·ml−1) and maximum plasma concentration (75.0 ng·ml−1) were lower than in subjects with normal renal function (19300 ng·ml−1; 122 ng·ml−1). The plasma protein binding of nifedipine averaged 95.5% in normal subjects and 94.8% in patients with renal failure. Although free and total steady-state plasma levels of nifedipine tended to be somewhat lower than normal in renal failure, the changes in pharmacokinetics and decreased protein binding of nifedipine did not result in a significantly different steady-state plasma level of the drug. The blood pressure response to a given plasma nifedipine level appeared to be enhanced in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558229
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A comparison of catecholamine concentrations and dopamine-β-hydroxylase activities in plasma from normotensive subjects and from patients with essential hypertension at rest and during exercise (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 561-565 
    Details
    ISSN: 1432-1440
    Keywords: Plasmakatecholamine ; Dopamin-β-Hydroxylase ; Essentielle Hypertonie ; Körperliche Belastung ; Plasma catecholamines ; Dopamine-β-hydroxylase ; Essential hypertension ; Physical exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 8 normotensive subjects and in 8 patients with essential hypertension total catecholamine content and dopamine-β-hydroxylase (DBH) activity in plasma were measured at rest and during physical exercise. Catecholamine levels at rest were significantly higher in the hypertensive than in the normotensive persons whereas the 2 groups of subjects did not differ in DBH activity at rest. At a work load of 150 watts there was a more pronounced increase of the catecholamine concentrations and of the DBH activity in the hypertensive patients than in the normotensives. One may conclude from the data that there is an increased sympathetic nerve activity in patients with essential hypertension.
    Notes: Zusammenfassung Bei 8 Normotonikern sowie bei 8 Patienten mit essentieller Hypertonie wurden die Konzentrationen der Gesamtkatecholamine und die Aktivität der Dopamin-β-Hydroxylase (DBH) im Plasma unter Ruhebedingungen und während körperlicher Belastung gemessen. Bei den Hypertonikern waren die Ruhewerte der Katecholamine signifikant höher als bei den Normotonikern, während die DBH-Aktivität unter diesen Bedingungen bei beiden Gruppen gleich war. Bei einer Ergometerbelastung von 150 Watt stiegen die Katecholaminspiegel und die DHB-Aktivität bei den Hochdruckkranken stärker an als bei den Probanden mit normalem Blutdruck. Aus den Untersuchungsergebnissen kann man schließen, daß bei Patienten mit essentieller Hypertonie eine erhöhte Aktivität sympathischer Nerven besteht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01619571
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    Paper (German National Licenses)
    Fulltext
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