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  • 1
    ISSN: 1432-1459
    Keywords: Benign hereditary chorea ; Positron emission tomography ; Glucose consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Positron emission tomography (PET) with [18F]-2-fluoro-2-deoxy-D-glucose (FDG) was used to investigate the regional cerebral metabolic rate of glucose consumption (rCMRGlc) in two patients with benign hereditary chorea (BHC) and 21 normal subjects. Relative and absolute values of cerebellar, striatal, thalamic, and cortical rCMRGlc were within normal limits for both patients with BHC, indicating that the choreic movement disorder encountered in these two patients was not caused by a decrease of energy metabolism in the striatum such as that found regularly in most patients with other forms of chorea (e.g. Huntington's and Wilson's disease).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1459
    Keywords: Huntington's disease ; Positron emission tomography ; Regional cerebral glucose consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Controversial data have been reported with regard to the diagnostic value of the positron emission tomographic (PET) measurement of striatal glucose consumption (rCMRGlc) in chorea-free subjects at risk of Huntington's disease (HD). For further clarification of this issue we measured striatal and cerebellar rCMRGlc in 27 chorea-free subjects at risk of HD, 20 patients with manifest HD and 20 control subjects, using PET and18F-fluorodeoxyglucose. In 6 of the at-risk subjects cerebellar ratios of striatal rCMRGlc were decreased below the corresponding 99% confidence limit determined in the controls. This indicates that the PET measurement of rCMRGlc may, indeed, be valuable in establishing the diagnosis of incipient HD in presymptomatic at-risk subjects.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 349 (1979), S. 544-545 
    ISSN: 1435-2451
    Keywords: Carotid artery stenosis ; Doppler examination ; Pressure gradient ; Angiography ; Stenose A. carotis interna ; Dopplersonographie ; Druckgradient ; Angiographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Bestimmung des Stenosegrades wurden Dopplersonographie und intraoperative Druckmessung mit der Standard-II-Ebenen Angiographie verglichen. Gruppe 1 (Stenose kleiner als 80 %): Doppler/Angio 63% (positive Korrelation); Druckgradient/Angio 84%; Doppler/Druckgradient 77%; mittlerer Gradient 12 mm Hg. Gruppe 2 (Stenose groβer als 80 %) : Doppler/Angio 82 %; Gradient/Angio 72 %, Doppler/Gradient 64 %, mittlerer Gradient 25 mm Hg. Die funktionelle Signifikanz der Stenose nahm bei geringerem Kollateralfluß zu, kenntlich an der dopplersonographischen ≫Überschätzung≪ und an einem relativ großen Gradienten. Aus klinischer Sicht sind Einengungen größer als 80 % ≫kritisch≪ und erfordern sofortige chirurgische Therapie, da in 4 von 15 Patienten lokale Verschlüsse auftraten, welche gerade noch rechtzeitig operabel waren.
    Notes: Summary The results of indirect and direct Doppler examination and pressure gradient determination were compared with the bilateral angiography in 50 patients with internal carotid artery stenosis. Group 1 (stenosis below 80 % square area reduction) : the accuracy of Doppler vs angiography was 63 %, pressure gradient vs angiography 84%, Doppler vs pressure gradient 77%, mean gradient 12 mmHg. Group 2 (more than 80% square area reduction), Doppler vs angiography 82 %, pressure gradient vs angiography 72 %, Doppler vs pressure gradient 64 %. Mean pressure gradient 25 mm Hg. In conclusion, every lumen reduction of more than 80 % is critical and surgical therapy is urgent, since sudden local occlusion occurred in 4 of 15 patients.
    Type of Medium: Electronic Resource
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