ISSN:
1420-9071
Keywords:
Porcine brain lipoamidase
;
activation and inhibition by phospholipids
;
phosphatidylethanolamine
;
phosphatidylserine
;
phospholipase A2
;
microsome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Phospholipids were added to purified lipoamidase from porcine brain microsomal membranes, and changes in lipoamidase activity were examined. Approximately twofold activation of lipoamidase activity occurred upon the addition of phosphatidylethanolamine. On the other hand, phosphosphatidylserine, cardiolipin, and phosphatidic acid reduced the enzyme activity by approximately 80%. This pattern of the activation of lipoamidase by phosphatidylethanolamine and its inhibition by phosphatidylserine is similar to the pattern for adenylate cyclase, and contrasts with the pattern for ATPase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01954229
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