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  • Follicular tumour  (1)
  • Key words. Clipping a convex polyhedron, Line-segment Voronoi diagram, Robust implementation, Topological consistency.  (1)
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  • 1
    ISSN: 1432-2307
    Keywords: Thyroid ; Follicular tumour ; Oxyphilic cell tumour ; PCNA ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of proliferative cell nuclear antigen (PCNA) in follicular tumours of the thyroid was examined by immunohistochemistry. Both usual nonoxyphilic cell follicular tumours (non-OCT) and oxyphilic cell tumours (OCT) were subdivided into benign, indeterminate, encapsulated carcinoma, and widely invasive carcinoma types. Among non-OCT the percentages of PCNA-positive cells in benign tumours, encapsulated carcinomas, and widely invasive carcinomas was 2.5%–8.6%, 11.8%–39.1%, and 18.6%–20.0%, respectively. There was a statistically significant difference between benign tumours and encapsulated or widely invasive carcinomas, as in previous studies. A value of 10% was appropriate to distinguish benign from malignant lesions. PCNA-positive cells in indeterminate-type non-OCT were not significantly different from those in benign tumours, ranging from 4.3%–19.6%, and occurring at more than 10% in three of six tuours. Among OCT the positivity was less than 10% in benign tumours (4.5%–7.8%) and more than 10% in malignant tumours (14.1%–35.9%) and all the eight indeterminate tumours (12.5%–27.3%), with a statistically significant differences between the benign tumour and each of the latter types. These results indicate that the examination of PCNA is valuable in diagnosis of thyroid follicular tumours and that the use of similar diagnostic criteria may be warranted in both non-OCT and OCT.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 27 (2000), S. 5-20 
    ISSN: 1432-0541
    Keywords: Key words. Clipping a convex polyhedron, Line-segment Voronoi diagram, Robust implementation, Topological consistency.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. This paper presents an approach, called the ``topology-oriented approach,'' to numerically robust geometric algorithms. In this approach, the basic part of the algorithm is described in terms of combinatorial and topological computation primarily; this description guarantees robustness of the algorithm because combinatorial and topological computation is never contaminated with numerical errors. However, this part of the algorithm is usually nondeterministic, the flow of processing containing many alternative branches. Hence, numerical computation is used in order to choose the branch that seems the most promising to lead to the correct answer. The algorithm designed in this way is robust and simple. The basic idea of this approach as well as the basic properties of the resulting algorithms is shown with examples.
    Type of Medium: Electronic Resource
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