Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Hyperthermia  (3)
  • Ftorafur  (2)
  • MNU-induced rat mammary carcinoma  (2)
  • Ratte  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of new estrogen-linked 2-chloroethylnitrosoureas (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 148-153 
    Details
    ISSN: 1432-1335
    Keywords: MNU-induced rat mammary carcinoma ; Treatment ; Estradiol-linked nitrosoureas ; Estrogenic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Short-term treatment of N-methyl-N-nitrosourea-induced mammary carcinomas in Sprague-Dawley rats with estradiol-linked nitrosoureas shows that the compounds in which the cytotoxic group is linked to position 17 of estradiol are superior to the 3-ester analogue. Moreover, N-(2-chloroethyl)-N-nitroso-carbamoyl (CNC)-l-alanyl-l-alanine-estradiol-3-ester is more effective and less toxic than CNC-l-alanine-estradiol-3-ester, being equivalent to ovariectomy in its therapeutic efficacy. Unlinked CNC-amino acid or-dipeptide in admixture with estradiol is less effective. Linked compounds at therapeutic dosages display estrogenic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390987
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Chemotherapy of autochthonous myeloid leukemias (Chloroleukemias) in Wistar rats (1981)
    Springer
    Journal of cancer research and clinical oncology 101 (1981), S. 243-248 
    Details
    ISSN: 1432-1335
    Keywords: Autochthonous (primary) myeloid leukemia ; Chloroleukemia ; Rat ; Chemotherapy ; Autochthone (primäre) myeloische Leukämie ; Chloroleukämie ; Ratte ; Chemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After injection of 15 mg/kg ethylnitrosourea (ENU) weekly for 15 weeks to adult male Wistar rats (total dose: 225 mg/kg) about 10% of the animals developed myeloid leukemias (chloroleukemias), which resemble the chronic myeloid leukemia in man (CML) (peripheral blood picture, tissue infiltration, chronic course as compared to immature-cell rat leukemias). Monotherapy with busulfan effected no remissions. The median survival time after daily treatment with busulfan was 29.5 days (range: 7–70); it was significantly shorter than that of untreated controls (median: 47.5 days, range: 22–81). After weekly application of 20 mg/kg and 50 mg/kg Cyclophosphamide the median survival time increase to 69.5 (range: 26–114) and 61.5 (range: 20–92) days, respectively. Rate and duration of remissions after repeated weekly single doses of cyclophosphamide were positively correlated with the increase in single dose; the high dose-intermittent treatment with 50 mg/kg CPA/week yielded complete remissions in all treated animals. Despite these remissions, however, no significant increase in survival time could be observed in comparison with untreated controls. The comparability of autochthonous chloroleukemias in the rat with human CML is discussed.
    Notes: Zusammenfassung Nach wöchentlicher Injektion von 15 mg/kg Äthylnitrosoharnstoffüber 15 Wochen in erwachsene männliche Wistar Ratten (Gesamtdosis: 225 mg/kg) entwickelten etwa 10% der Tiere Chloroleukämien, die eine auffallende Ähnlichkeit mit der chronischen myeloischen Leukämie (CML) des Menschen haben (peripheres Blutbild, Gewebsinfiltration, chronischer Verlauf beim Vergleich mit unreifzelligen Rattenleukämien). Eine Monotherapie mit Busulfan bewirkte keine Remissionen. Nach täglicher Behandlung mit Busulfan lag die mediane Überlebenszeit bei 29,5 Tagen (Spanne: 7–70 Tage) und war somit kürzer als die der unbehandelten Kontrolltiere (mediane Überlebenszeit: 47,5 Tage; Spanne: 22–81 Tage). Nach wöchentlicher Behandlung mit 20 mg/kg sowie mit 50 mg/kg Cyclophosphamid (CPA) stieg die mediane Überlebenszeit auf 69,5 (Spanne: 26–114) bzw. 61,5 (Spanne: 20–92) Tage an. Die Remissionsrate und die Remissionsdauer nach wöchentlich wiederholten Einzeldosen von Cyclophosphamid zeigten eine positive Korrelation zur Höhe der Einzeldosis; so bewirkte eine intermittierende Behandlung mit 50 mg/kg CPA/Woche bei allen behandelten Ratten eine komplette Remission. Trotz der Remissionen konnte jedoch kein signifikanter Anstieg der Überlebenszeit beim Vergleich mit den unbehandelten Kontrollen beobachtet werden. Die Vergleichbarkeit der autochthonen Chloroleukämie der Ratte mit der CML des Menschen wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410110
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: Monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 115-131 
    Details
    ISSN: 1432-1335
    Keywords: Autochthonous colonic tumors ; N-nitrosoacetoxymethyl-methylamine ; 1,2-Dimethylhydrazine ; 5-Fluorouracil ; Ftorafur ; CGP 6809 ; CGP 15'720A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29–42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402060
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Development of second malignancies in rats after cure of acute leukemia L 5222 by single doses of 2-chloroethylnitrosoureas (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 83-86 
    Details
    ISSN: 1432-1335
    Keywords: 2-Chloroethylnitrosoureas ; Carcinogenesis ; Rat ; 2-Chloroethylnitrosoharnstoffe ; Carcinogenese ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Heilung der akuten Rattenleukämie L 5222 bei 79 BD IX Ratten mit einmaligen Dosen von 1,3-bis(2-Chloroethyl)-1-nitrosoharnstoff (BCNU) oder 1-(2-Hydroxyethyl)-3-(2-Chloroethyl)-3-nitrosoharnstoff (Hydroxyethyl-CNU) entwickelten sich bei insgesamt 9 Tieren (∼ 11%) sekundäre Malignome.
    Notes: Summary After cure of rat leukemia L 5222 in 79 BD IX rats by single doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (Hydroxyethyl-CNU) a total of 9 rats (11%) developed secondary malignomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411113
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Anticancer activity of bisphosphonic acids in methylnitrosourea-induced mammary carcinoma of the rat — benefit of combining bisphosphonates with cytostatic agents (1988)
    Springer
    Investigational new drugs 6 (1988), S. 155-167 
    Details
    ISSN: 1573-0646
    Keywords: MNU-induced rat mammary carcinoma ; bisphosphonic acids ; anticancer agent-linked biphosphonic acids ; melphalan ; combination effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary This study primarily describes the cytostatic activity of a bisphosphonate and of an alkylating agent linked bisphosphonate toward mammary carcinomas in vivo. Bisphosphonates had been shown to be therapeutically active in bone metastases. There is no animal tumor model available in which both primary mammary carcinomas and bone metastases can be studied simultaneously. Therefore, the Walker carcinosarcoma model, which was used as a model for bone metastasis in earlier studies, was combined with the M-methyl-N-nitrosourea (MNU) induced mammary carcinoma as a model for the primary tumor. Four-, or six-week treatment of MNU-induced mammary carcinomas in Sprague-Dawley rats with the new aromatic bisphosphonate 4[4-[bis(2-chloroethyl)-amino]-phenyl]-1-hydroxybutane-1,1-bisphosphonate (BAD) showed higher antitumor activity than treatment with melphalan or with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) alone. BAD is the APD moiety covalently bound to a molecule derived from melphalan. A combination therapy with 11.75 mg/kg/day APD and 0.6 mg/kg/day melphalan showed the best therapeutic efficacy in this tumor model. In comparison to monotherapy with BAD, APD, or melphalan, a significantly higher rate of complete remissions was achieved. APD, itself, was not genotoxic in 3 employed short term assays. Since bisphosphonates had been shown to be therapeutically active in bone metastases, the antitumor potency of these compounds against experimental primary mammary carcinomas, coupled with the non-genotoxicity of APD and the inhibition of osteolytic bone metastases, might be an important advancement for adjuvant chemotherapy of human mammary carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175392
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Wirkung der lokalen moderaten Hyperthermie in Kombination mit N-Nitroso-1,3-bis-(2-chlorethyl)-harnstoff (BCNU) und 5-Fluor-(tetrahydro-2-furyl)-uracil (Ftorafur) auf induzierte autochthone Coloncarcinome der Ratte (1984)
    Springer
    Langenbeck's archives of surgery 363 (1984), S. 5-15 
    Details
    ISSN: 1435-2451
    Keywords: Hyperthermia ; Induced colonic carcinoma ; Rat ; Chemotherapy ; BCNU ; Ftorafur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Hyperthermie zur Behandlung von Tumoren wird seit längerem in In-vitro- und In-vivo-Versuchen und auch in der Klinik in verschiedenen Anwendungsformen erprobt. Bei der Kombination von Hyperthermie mit Chemotherapie wird eine überadditive cytostatische Wirkung beschrieben. In einem klinisch orientierten, kontrolliert durchgeführten Tierversuch wurde an einem durch N-Nitrosoacetoxymethylmethylamin (AMMN) induzierten autochthonen Coloncarcinom bei Sprague-Dawley-Ratten eine lokale, moderate Hyperthermie (43,5°C, 3 × 60 min) und eine Kombinationsbehandlung von Hyperthermie und Polychemotherapie (BCNU und Ftorafur) durchgeführt unter endoskopischer Diagnosestellung und Verlaufskontrolle. Es konnte keine Überlebenszeitverlängerung durch die angewendeten Therapien und keine additive Wirkung der lokalen moderaten Hyperthermie in Kombination mit der Chemotherapie bei diesem „harten”, d. h. relativ chemotherapieresistenten, Tumormodell gesehen werden.
    Notes: Summary The use of hyperthermia for the treatment of tumors has been tested in in vitro and in vivo experiments as well as clinically for a long time. Combination of hyperthermia with chemotherapy was reported to result in overadditive cytostatic effects. In a clinically adapted, controlled animal experiment, local moderate hyperthermia (43.5°C, 3 × 60 min) alone and in combination with polychemotherapy (BCNU and Ftorafur) was used for the treatment of AMMN-(N-nitrosoacetoxymethyl-methylamine) induced autochthonous colonic carcinomas in Sprague-Dawley rats. Diagnosis and follow-up inspections were carried out endoscopically. The applied therapies did not result in prolonged survival times, nor was an additive effect seen after combined hyperthermia and chemotherapy in this “hard”, i. e. relatively chemotherapy-resistent, tumor model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01255773
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch Cyclophosphamid oder N-Nitroso-1,3-bis-(2-chlorethyl harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom (1983)
    Springer
    Langenbeck's archives of surgery 359 (1983), S. 205-213 
    Details
    ISSN: 1435-2451
    Keywords: Hyperthermia ; Yoshida sarcoma ; Chemotherapy ; Cyclophosphamide ; BCNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Anwendung der Hyperthermie zur Cytostase wird seit langem diskutiert. In der letzten Zeit stellte sich die Frage, ob durch eine Kombination der Chemotherapie mit der Hyperthermie die Erfolgsaussichten verbessert werden können. Zur experimentellen Überprüfung dieser Hypothese verwendeten wir einen gastrointestinalen Impftumor. Yoshida-Sarkom-Asci teszellen wurden in einer Konzentration von 2 x 106 in das Colon descendens von 101 Sprague-Dawley-Ratten implantiert. Gleichzeitig wurde ein doppel läufiger Anus praeter angelegt. Am 6. Tage nach Operation erfolgte die Chemotherapie, 24h danach eine lokale Hyperthermie, welche mittels einem in das stillgelegte Colon descendens eingeführten Silikonschlauch durchgeführt wurde. Die erreichte Temperatur betrug im Tumor 43 ± 0,5°C. Akute toxische Wirkungen der Hyperthermie wurden nicht beobachtet, ein Anstieg der Körpertemperatur konnte durch Kühlung im Normbereich gehalten werden. Anhand der Überlebenszeitkurven zeigten sich statistisch gesicherte Unterschiede zwischen den Gruppen mit Chemotherapie und der Kontrollgruppe, eine additive Wirkung der Hyperthermie konnte aber nicht aufgezeigt werden. Die alleinige Anwendung der Hyperthermie zeigte ebenso keinen Vorteil gegenüber der Kontrolle. Die Ergebnisse bestätigen die Skepsis über die therapeutische Wirksamkeit der Hyperthermie und unterstreichen die Notwendigkeit zur weiteren Überprüfung im klinisch orientierten Tierversuch.
    Notes: Summary. The application of hyperthermia in cytostatic therapy has been discussed for a long time. Recently the question arose whether the chances of therapy might be improved by combining chemotherapy with hyperthermia. We used an inoculated gastrointestinal tumor to verify this hypothesis experimentally. 2 x 106 Yoshida sarcoma ascites cells were implanted in the descending colon of 101 Sprague-Dawley rats. A preternatural anus with two lumina was established concomitantly. Chemotherapy started on day 6 after surgery. 24 h later local hyperthermia was applied by means of a silicone tube inserted in the immobilized descending colon. The temperature in the tumor was raised to 43 ± 0.5°C. No acute toxic effects of hyperthermia were noted. The body temperature was kept from rising above normal by cooling. The differences in survival time between the chemotherapeutically treated groups and the control group were statistically validated. Additional hyperthermia did not result in additive effects. No advantage of hyperthermia alone was noted over the control. The results support scepticism about the therapeutic efficacy of hyperthermia and underline the necessity of further investigations in clinically adapted animal experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250983
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-Nitroso-1,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom (1984)
    Springer
    Langenbeck's archives of surgery 362 (1984), S. 253-261 
    Details
    ISSN: 1435-2451
    Keywords: Hyperthermia ; Yoshida sarcoma ; Chemotherapy ; BCNU ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Hyperthermie zur Cytostase von Malignomen ist in zahlreichen In-vitro- und In-vivo-Untersuchungen beschrieben worden. Die Kombination von Chemotherapie mit Hyperthermie soll zur Potenzierung der therapeutischen Wirkung führen. Ein Forschungsgegenstand ist der zeitliche Abstand zwischen beiden Therapiemodalitäten. Anhand eines Yoshida-ColonModells bei Sprague-Dawley-Ratten wurde eine lokale Hyperthermie (43°C, 60 min) im Abstand von 0, 3, 6, 9, 12 und 24 h nach einer Chemotherapie mit BCNU durchgeführt. Die Ergebnisse zeigten keine signifikante Steigerung der Heilungsrate durch die Hyperthermie. Angesichts unserer Ergebnisse sollten z.B. die mit groben Hoffnungen propagierten hyperthermen Peritoneallavagen erst im Tierexperiment einer kontrollierten Untersuchung unterzogen werden.
    Notes: Summary There are numerous reports on in vitro and in vivo investigations of hyperthermia for cytostasis of malignant tumors. Combination of chemotherapy and hyperthermia is to potentiate the therapeutic effect. The time interval between the two types of therapy was the main subject of the present investigation. Local hyperthermia (43°C, 60 min) following BCNU chemotherapy at intervals of 0, 3, 6, 9, 12, and 24 h, respectively, was studied in a colonic Yoshida sarcoma model in Sprague-Dawley rats. No significant increase in the curing rate resulted from hyperthermic treatment. The results suggest that the highly anticipated hyperthermic peritoneal lavages should be investigated in controlled animal experiments prior to clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254653
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...