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  • 1
    Electronic Resource
    Electronic Resource
    Geschichtliche Entwicklung der extrakorporalen Zirkulation Isolierte Organperfusion im 19. Jahrhundert (2000)
    Springer
    Zeitschrift für Herz-, Thorax- und Gefässchirurgie 14 (2000), S. 93-99 
    Details
    ISSN: 0930-9225
    Keywords: Schlüsselwörter Kardiopulmonaler Bypass ; Geschichte ; Bubble-Oxygenator ; Film-Oxygenator ; Key words Cardiopulmonary bypass ; history ; bubble-oxygenator ; film-oxygenator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Historic development of extracorporeal circulation began with the perfusion of isolated organs by physiologists in the 19th century. Those experiments led to the development of the basic principles of the perfusion technique, such as bubble-oxygenation and film-oxygenation, systems for pulsatile pumping and the closed extracorporeal circuit. The idea for using extracorporeal circulation for cardiovascular surgery was born at the beginning of the 20th century.
    Notes: Zusammenfassung Die historische Entwicklung der extrakorporalen Zirkulation begann mit den isolierten Organperfusionen der Physiologen des 19. Jahrhunderts. Diese Experimente führten zur Entwicklung der Grundlagen der Perfusionstechnik, wie der Bubble- und Film-Oxygenation, sowie pulsatilen Pumpensystemen und dem geschlossenen extrakorporalen Kreislauf. Die Vorstellung, dass die extrakorporale Zirkulation im Zusammenhang mit herz- oder gefäßchirurgischen Eingriffen genutzt werden könnte, entstand schon zu Beginn des 20. Jahrhunderts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003980070028
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  • 2
    Electronic Resource
    Electronic Resource
    Soluble L -selectin plasma concentrations in infants undergoing heart surgery: no association with capillary leak syndrome or need for respiratory support (1998)
    Springer
    Intensive care medicine 24 (1998), S. 1093-1098 
    Details
    ISSN: 1432-1238
    Keywords: Key words Infant ; Congenital heart disease ; ARDS ; Capillary leak ; Soluble l-selectin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: In critical care patients at risk of developing the acute respiratory distress syndrome (ARDS), low soluble l-selectin (sCD62L) plasma concentrations have been shown to be associated with progression to ARDS and prolonged subsequent mechanical ventilation. This study aimed to determine the usefulness of sCD62L plasma concentrations to identify infants undergoing cardiovascular surgery who are at risk for postoperative pulmonary dysfunction and capillary leaks. Design: Serial measurements of sCD62L plasma concentrations in a cohort of infants with congenital heart disease before, during, and after surgery for 4 consecutive days. Setting and patients: Infants aged 3–337 days undergoing cardiovascular surgery with (N = 27) or without (N = 12) cardiopulmonary bypass in a tertiary care center. Results: sCD62L concentrations before surgery showed a strong correlation with the infant's age (r = 0.77, p 〈 0.001). During surgery, sCD62L levels dropped from 9.0 ± 0.7 to 5.6 ± 0.4 nmol/l (mean ± SEM; p 〈 0.001). The minimum sCD62L concentration during and after surgery did not differ between infants operated upon with or without cardiopulmonary bypass (p 〉 0.1) or in infants who did (N = 10) or did not (N = 29) develop capillary leak syndrome. Whereas capillary leak syndrome was associated with prolonged mechanical ventilation (p 〈 0.01), there was no relationship between sCD62L concentrations at baseline or at any time thereafter and number of hours on the ventilator (p 〉 0.1). Conclusion: sCD62L concentrations before or after surgery are not apt to identify infants at increased risk of prolonged mechanical ventilation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050722
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    Paper (German National Licenses)
    Fulltext
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