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  • 1
    ISSN: 1437-1596
    Keywords: Key words SIDS ; Endocrine pancreas ; Morphology ; Immunohistochemistry ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The pancreatic islets from 112 infants (66 males and 46 females) who died of SIDS during the years 1990– 1992 have been studied. The control group consisted of endocrine pancreas tissue from 19 infants who died of a clear cause of death (pneumonia, drowning, sepsis, etc.). The mean age of the SIDS group was 5.1 months. We found histologically normally developed organs in all the SIDS cases. By evaluating the relative endocrine cell area of the pancreas by immunohistochemical investigations, A-cells were found to make up 10–30%, B-cells 30–60%, D-cells 10–30% and pancreatic polypeptide cells less than 10% in the SIDS group and in the controls with a small increase in glucagon and insulin cells among SIDS cases. The morphometric evaluation revealed that cell enlargement and cytoplasm shrinking occurred slightly more often in the SIDS group than in the control group. The diameter of the islets was normal and the maximal volume was not enlarged. The results did not show significant differences so that a relationship between alterations of the endocrine pancreas and sudden infant death syndrome could not be demonstrated.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 808-816 
    ISSN: 1432-1440
    Keywords: Acute renal failure ; Glomerulonephritis ; Hemolyticuremic syndrome ; Acute interstitial nephritis ; Rapidly progressive glomerulonephritis ; Akutes Nierenversagen ; Glomerulonephritis ; hämolytisch-urämisches Syndrom ; akute interstitielle Nephritis ; rapid-progressive Glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die pathologisch-anatomischen Diagnosen berichtet, die bei 180 Fällen von klinisch diagnostiziertem ANV erhoben wurden. Im einzelen wird dabei gezeigt, daß in 43,3% der Fälle klinische und pathologische Diagnosen übereinstimmen. In 56,7% der Fälle wurden pathologisch-anatomisch von der Klinik abweichende Diagnosen gestellt. Besonders häufig verbarg sich hinter einem ANV eine GN, darunter vorwiegend eine RPGN, ferner eine akute interstitielle Nephritis oder ein HUS. Darüber hinaus werden die klinischen Diagnosen bei pathologisch-anatomisch diagnostiziertem ANV aufgezeigt. Schließlich wird über die klinischen Diagnosen bei pathologisch-anatomischer Diagnose GN + ANV berichtet. Es wird dabei darauf hingewiesen, daß der Pathologe in der Lage ist, GN mit echter kompensierter Retention von einer GN mit passagerem, eine kompensierte Retention vortäuschendem ANV zu unterscheiden.
    Notes: Summary This study reports the pathological-anatomical diagnoses in 180 cases in which a diagnosis of acute renal failure (ARF) had been made on clinical grounds. The clinical and pathological diagnoses were in agreement in 43.3% of the cases. In 56.7%, the pathological-anatomical diagnosis differed from the clinical diagnosis. Glomerulonephritis (GN) was particularly often concealed behind ARF, in particular rapidly progressive GN, but also acute interstitial nephritis or hemolyticuremic syndrome. In addition, the clinical diagnoses in cases with a pathological-anatomical diagnosis of ARF are presented. Finally, the clinical diagnoses made in cases with a pathological-anatomical diagnosis of GN with ARF are reported. It is thus shown that the pathologist is in a position to distinguish GN with true compensated retention from GN with transient ARF simulating compensated retention.
    Type of Medium: Electronic Resource
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