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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 808-816 
    ISSN: 1432-1440
    Keywords: Acute renal failure ; Glomerulonephritis ; Hemolyticuremic syndrome ; Acute interstitial nephritis ; Rapidly progressive glomerulonephritis ; Akutes Nierenversagen ; Glomerulonephritis ; hämolytisch-urämisches Syndrom ; akute interstitielle Nephritis ; rapid-progressive Glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die pathologisch-anatomischen Diagnosen berichtet, die bei 180 Fällen von klinisch diagnostiziertem ANV erhoben wurden. Im einzelen wird dabei gezeigt, daß in 43,3% der Fälle klinische und pathologische Diagnosen übereinstimmen. In 56,7% der Fälle wurden pathologisch-anatomisch von der Klinik abweichende Diagnosen gestellt. Besonders häufig verbarg sich hinter einem ANV eine GN, darunter vorwiegend eine RPGN, ferner eine akute interstitielle Nephritis oder ein HUS. Darüber hinaus werden die klinischen Diagnosen bei pathologisch-anatomisch diagnostiziertem ANV aufgezeigt. Schließlich wird über die klinischen Diagnosen bei pathologisch-anatomischer Diagnose GN + ANV berichtet. Es wird dabei darauf hingewiesen, daß der Pathologe in der Lage ist, GN mit echter kompensierter Retention von einer GN mit passagerem, eine kompensierte Retention vortäuschendem ANV zu unterscheiden.
    Notes: Summary This study reports the pathological-anatomical diagnoses in 180 cases in which a diagnosis of acute renal failure (ARF) had been made on clinical grounds. The clinical and pathological diagnoses were in agreement in 43.3% of the cases. In 56.7%, the pathological-anatomical diagnosis differed from the clinical diagnosis. Glomerulonephritis (GN) was particularly often concealed behind ARF, in particular rapidly progressive GN, but also acute interstitial nephritis or hemolyticuremic syndrome. In addition, the clinical diagnoses in cases with a pathological-anatomical diagnosis of ARF are presented. Finally, the clinical diagnoses made in cases with a pathological-anatomical diagnosis of GN with ARF are reported. It is thus shown that the pathologist is in a position to distinguish GN with true compensated retention from GN with transient ARF simulating compensated retention.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-5196
    Keywords: Key words Cyanogen compounds ; Lethal oral ; intoxication ; Ability to act ; Schlüsselwörter Cyan-Verbindungen ; Tödliche orale Intoxikation ; Handlungsfähigkeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Einschätzung der Handlungsfähigkeit eines tödlich Vergifteten kann bei der Tatrekonstruktion sehr bedeutsam sein, insbesondere bei der Frage „Selbst- oder Fremdbeibringung des Giftes“. Klinische Publikationen gehen hierauf kaum ein. Deshalb wurden 27 Fälle tödlicher oraler Intoxikationen mit Cyan-Verbindungen der rechtsmedizinischen Institute Würzburg, Hamburg, München, Berlin (FU), Tübingen, Essen und Leipzig, bei denen eine Aussage zur Handlungsfähigkeit des später Verstorbenen möglich war, sowie die dazugehörigen polizeilichen und staatsanwaltschaftlichen Akten unter dieser Fragestellung ausgewertet. Ergebnis: in der Mehrzahl der Fälle betrug die Handlungsfähigkeit nur wenige Sekunden bis maximal 1 bis 2 Minuten. Im Untersuchungsgut und in der Literatur kamen allerdings auch Fälle vor, bei denen die Handlungsfähigkeit über ca. 5 bis 10 min erhalten war. Die Ergebnisse der Arbeit sollen dem Gutachter als Leitlinie bei der Klärung einschlägiger Fälle dienen.
    Notes: Abstract An accurate assessment of the duration of the ability to act of a victim of lethal poisoning can be of crucial importance in reconstructing the cause of the poisoning, especially in determining whether the poison was taken by the victim or given by another. Clinical studies have scarcely dealt with this problem. We therefore investigated 27 cases of lethal oral intoxication with cyanogen compounds on file at the university institutes of forensic medicine in Würzburg, Hamburg, Munich, Berlin (Free University), Tübingen, Essen and Leipzig with regard to the victim’s postintoxication ability to act. In addition we examined the records of the respective police and prosecuters offices as well as the relevant literature. In most cases the ability to act lasted only a few seconds to a maximum of 1–2 min. However, in some of the 27 cases the ability to act lasted for 5–10 min, a finding which agrees with reports in the literature. The present study is intended to provide forensic expert witnesses with guidelines for clarifying similar cases of lethal oral intoxication.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1437-1596
    Keywords: Key words SIDS ; Endocrine pancreas ; Morphology ; Immunohistochemistry ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The pancreatic islets from 112 infants (66 males and 46 females) who died of SIDS during the years 1990– 1992 have been studied. The control group consisted of endocrine pancreas tissue from 19 infants who died of a clear cause of death (pneumonia, drowning, sepsis, etc.). The mean age of the SIDS group was 5.1 months. We found histologically normally developed organs in all the SIDS cases. By evaluating the relative endocrine cell area of the pancreas by immunohistochemical investigations, A-cells were found to make up 10–30%, B-cells 30–60%, D-cells 10–30% and pancreatic polypeptide cells less than 10% in the SIDS group and in the controls with a small increase in glucagon and insulin cells among SIDS cases. The morphometric evaluation revealed that cell enlargement and cytoplasm shrinking occurred slightly more often in the SIDS group than in the control group. The diameter of the islets was normal and the maximal volume was not enlarged. The results did not show significant differences so that a relationship between alterations of the endocrine pancreas and sudden infant death syndrome could not be demonstrated.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 110 (1997), S. 63-68 
    ISSN: 1437-1596
    Keywords: Key words Sudden infant death ; Lymph nodes ; Thymus ; Histology ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract In 50 cases of sudden infant death cervical, paratracheal and lung hilar lymph nodes, the thymus and the spleen were investigated by histology and immunohistochemistry (CD 20, 21, 45RO). The cases were divided into 3 groups based on autopsy findings including extensive histology: A – without pathological changes (N = 12), B – with minimal to intermediate inflammation (N = 23) and C – with severe inflammation (N = 15). In accordance with previous results the frequency of “pathological” lymph node changes, such as paracortical lymphoid hyperplasia and variegated hyperplasia of the pulp increased from group A to group C. The B-cell antigens reacted accordingly. A pronounced lymphodepletation of the thymus as a sign of a long lasting stimulation of the T-cell system was also observed increasingly from group A to C. In summary, in none of the cases results obtained were indicative of a defect of the T- or B-cell system. The results in group A seem to indicate that changes in the reaction pattern of the lymphoid tissues could be a more sensitive method of detection of early stages of inflammation than local histology.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 113 (2000), S. 320-331 
    ISSN: 1437-1596
    Keywords: Key words Time since death ; Compound method ; Practical casework
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The period since death was estimated at the scene in 72 consecutive cases using the temperature-based nomogram method as the primary method and supplemented by examination of criteria such as lividity, rigor mortis, mechanical and electrical excitability of skeletal muscle and chemical excitability of the iris. A case-oriented, computer-assisted selection of the non-temperature-based methods and integration of the results into a common result of the compound method was made following a special logistic. The limits of the period since death as estimated by the nomogram were improved in 49 cases by including the non-temperature-based methods and also provided results in 4 cases where the temperature method could not be used. In a further 6 cases the non-temperature-based methods confirmed the limits estimated by the temperature method but in 14 cases a useful result could not be obtained. In only one of the cases investigated was the upper limit of the period since death, as estimated by the criterion re-establishment of rigor (8 h post-mortem), in contradiction with the period determined by the police investigations (9.4 h post-mortem).
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1437-1596
    Keywords: Key words Time since death ; Nomogram method ; Rectal temperature ; Practical casework
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The temperature-based nomogram method for estimation of the time period since death was used at the scene of death as the primary method within a compound method in 72 consecutive cases. The situation and cooling conditions inspected and evaluated by the forensic pathologist at the scene are described as far as necessary to ¶enable handling of the method. A comparison of the ¶estimated period since death with the period determined by the police investigations demonstrates the reliability ¶of the method. There were no contradictions in any of the 60 cases between the period of death estimated by this method and that determined by the police investigations. The criminal investigations were effectively supported in the earliest stages in 11 cases despite the fact that the period estimated was of considerable duration.
    Type of Medium: Electronic Resource
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