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  • Monoclonal antibody  (3)
  • Granular cell tumors  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Granular cell brain tumors of the laboratory rat: an immunohistochemical approach (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 112-117 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Rat brain tumors ; Granular cell tumors ; Immunohistochemistry ; Astrocytoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have studied paraffin-embedded specimens of 17 rat granular cell brain tumors (GCBT) from four long-term drug safety carcinogenicity studies by peroxidase-antiperoxidase (PAP) immunohistochemistry with either polyvalent or monoclonal antibodies against glial fibrillary acidic protein (GFAP), S-100 protein (S-100), Leu-7 epitopes, vimentin (VIM), keratin, desmin, and myelin basic protein. We have found that 9 of the 17 GCBT contained GFAP-positive, S-100-positive, and VIM-positive astrocytes, while GFAP-positive and VIM-positive granular cells were observed in 5 of these 9 tumors. Our findings indicate that astroglial cells are involved in rat GCBT and suggest that an astrocytic origin should be considered for these neoplasms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00293953
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Immunohistochemical recognition of human neuroepithelial tumors by anti-Leu 7 (HNK-1) monoclonal antibody (1986)
    Springer
    Acta neuropathologica 69 (1986), S. 227-233 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Leu 7 ; HNK-1 ; Monoclonal antibody ; Gliomas ; Neuroepithelial tumors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The immunoreactivity of the anti-Leu 7 (HNK-1) monoclonal antibody, a marker for natural killer cells, was evaluated with the peroxidase-antiperoxidase (PAP) method on sections of human paraffin-embedded tissues from 135 tumors of the central nervous system and five esthesioneuroblastomas. As shown independently by others, the antibody was found to react with most types of neoplastic neuroepithelial cells. Our findings indicate that the reaction is most often localized on the cytoplasmic membranes. The immunoreactive cell membranes were generally those of well-differentiated tumor cells and of neoplastic cells found in tumors that usually were not embryonal in nature. Parallel immunostaining either of the same or of successive sections with an anti-glial fibrillary acidic protein serum was of considerable assistance in discriminating between different immunoreactive cells, e.g., between astrocytes and cells presumed to be oligodendrocytes. Despite its cross-recognition of cells of various histogenesis, the anti-Leu 7 monoclonal antibody can, in well-defined circumstances, elucidate specific differential diagnostic problems involving neurogenic neoplasms that cannot be resolved with routine staining techniques.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688298
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  • 3
    Digitale Medien
    Digitale Medien
    Immunohistochemical recognition of human nerve sheath tumors by anti-Leu 7 (HNK-1) monoclonal antibody (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 319-324 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Anti-Leu 7 ; HNK-1 ; Monoclonal antibody ; Myelin-associated glycoprotein ; Schwannoma ; Neurofibroma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Using relatively high dilutions of anti-Leu 7 monoclonal antibody and a four-step peroxidase-antiperoxidase (PAP) reaction in paraffin-embedded tissues, we tested the affinity of this antibody to the cells of 47 human nerve sheath tumors and 22 other tumors in which the differential diagnosis with nerve sheath neoplasms is known to arise. Of all the nerve sheath tumors studied 68%, including 80% of the schwannomas, contained anti-Leu 7-positive cells. All 22 non-schwannian neoplasms were entirely, negative. Specimens of eight experimental malignant rat schwannomas were also negative for anti-Leu 7 antibody. Our findings suggest that anti-Leu 7 monoclonal antibody is a promising marker that may facilitate the differential diagnosis between human Schwann cell and non-schwann cell neoplasms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00690835
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  • 4
    Digitale Medien
    Digitale Medien
    S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 224-227 
    Details
    ISSN: 1432-0533
    Schlagwort(e): S-Antigen ; Monoclonal antibody ; Pineal gland ; Pineocytoma ; Pineoblastoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688043
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