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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Annals of hematology 39 (1979), S. 117-131 
    ISSN: 1432-0584
    Schlagwort(e): Non-Hodgkin lymphoma ; T-zone lymphoma ; T-cellimmunoblastic sarcoma ; Peripheral T-cell lymphoma ; Non-Hodgkin-Lymphom ; T-Zonen-Lymphom ; T-immunoblastisches Sarkom ; peripheres T-Zellen-Lymphom
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Anhand von 32 Patienten mit T-Zonen-Lymphom wurden klinisches Bild, Ansprechen auf die Therapie und die Prognose dieser neuen Lymphom-Entität analysiert. Das Krankheitsbild entwickelt sich relativ rasch mit generalisierten Lymphknotenschwellungen und Beeinträchtigung des Allgemeinbefindens. Häufig sind Hepato- und/oder Splenomegalie und Hauteffloreszenzen vorhanden. Einige Patienten zeigen hyperimmunisatorische Reaktionen, selten auch schwere autoimmunhämolytische Anämien. Die Blutkörperchensenkungsgeschwindigkeit ist meistens stark beschleunigt; die Immunglobuline sind zum Teil polyklonal vermehrt, zum Teil auch vermindert. In einigen Fällen finden sich ganz vereinzelt atypische Lymphozyten in Blut- und Sternalmarkausstrichen. Auffallend ist die häufige Absiedlung in Lunge oder Pleura (bei 40,5% der Patienten). Die Prognose ist ungünstig. Die Mehrzahl der Erkrankten befindet sich bei Diagnosestellung bereits in den Stadien III und IV. Organinfiltration und -Verdrängung bei weitgehender Resistenz gegenüber den üblichen therapeutischen Maßnahmen und zunehmender Abwehrschwäche führen rasch ad exitum. Die Überlebenswahrscheinlichkeit beträgt 0,48 für das 1. Jahr nach Diagnosestellung. Die Prognose der Patienten in den Stadien I und II ist deutlich besser als die der Patienten in den Stadien III und IV.
    Notizen: Summary The clinical symptoms, response to therapy, and prognosis of T-zone lymphoma were analyzed in 32 cases. This recently defined lymphoma entity developed relatively quickly with generalized lymphadenopathy and general malaise. Hepatomegaly and/or splenomegaly and skin efflorescence were frequent presenting symptoms. A few patients showed hyperimmune reactions and occasionally severe autoimmune hemolytic anemia. The erythrocyte sedimentation rate was usually markedly elevated. There was sometimes a polyclonal increase in serum immunoglobulin, sometimes a reduction. Blood and bone marrow smears from a few patients showed occasional atypical lymphocytes. A remarkable finding was the frequent involvement of lung or pleura (40.5% of the patients). The prognosis is unfavorable. Most of the patients were in stages III or IV at the time of diagnosis. Massive infiltration of organs, resistance to routine therapy, and decreasing resistance to infection resulted in death soon after diagnosis. The probability of survival was 0.48 in the first year after diagnosis. The prognosis for patients in stages I and II was clearly better than that for patients in stages III and IV.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 373 (1977), S. 303-309 
    ISSN: 1432-2307
    Schlagwort(e): Immunocytoma ; Malignant lymphoma, lymphoplasmacytoid ; Chronic lymphocytic leukemia ; Tissue mast cell count and distribution ; Differential diagnostic parameters in lymph node biopsies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The amount and distribution of tissue mast cells in the three subtypes of immunocytoma (IC) were studied in lymph nodes of 58 cases and compared with the findings on 34 cases of chronic lymphocytic leukemia (CLL). There were significantly more mast cells in the lymphoplasmacytic and lymphoplasmacytoid subtypes of IC than in CLL. The median mast cell count for the polymorphic subtype of IC was also greater than that for CLL; however, this difference was not statistically significant. Tissue mast cells were diffusely distributed in the lymph nodes in IC, whereas they were chiefly located in the sinus in CLL. Moreover, the cells themselves and their granules were generally larger in IC. Increase in the number and altered distribution of the tissue mast cells in histological sections are therefore diagnostic aids for distinguishing IC from CLL.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-0584
    Schlagwort(e): Non-Hodgkin lymphoma ; Kiel classification ; Low-grade malignancy ; High-grade malignancy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary On the basis of the retrospective analysis of 405 patients, suggesting the clinical relevance of the Kiel classification of non-Hodgkin lymphomas (NHL), a prospective multicenter study was started on October 1st, 1975, by the Kiel Lymphoma Study Group in order to further clarify the clinical and prognostic features of the different lymphoma entities defined by this histopathologic scheme. Diagnostic protocol provides initial staging evaluation according to a modification of the Ann Arbor classification. Therapeutic approach is based on the hypothesis that, like Hodgkin's disease, NHL originate, at least in part, as localized lymphatic or extralymphatic tumors. Thus, extended field irradiation is performed in stages I and II (except for lymphoblastic lymphoma in children and young adults) whereas in the more advanced stages III and IV (except for stage III of centroblastic-centrocytic lymphoma) chemotherapy with additional radiotherapy is applied. Until June 1979, 815 patients entered the study (69.7% with NHL of low-grade malignancy). For the interim evaluation underlying the present and the other papers of this series data of 511 patients were available. Survival of patients with NHL of low-grade malignancy significantly exceeds that of patients with NHL of high-grade malignancy. NHL with good prognosis such as chronic lymphocytic leukaemia and centroblastic-centrocytic lymphoma can be differentiated from NHL with a poor course such as lymphoblastic and immunoblastic lymphomas. In addition, the existence of a third group with an intermediate prognosis comprising centrocytic and centroblastic lymphomas and, possibly, also LP immunocytoma is suggested. However, different initial slope of survival curves shows that this latter group of NHL is not homogeneous with regard to prognosis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1432-0584
    Schlagwort(e): Non-Hodgkin lymphoma ; Kiel classification ; Rappaport classification
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Using the Kiel and the Rappaport classifications, a comparative histopathological analysis of 486 cases with non-Hodgkin lymphomas from a prospective study of the Kiel Lymphoma Study Group, still in progress, was performed. The greater part of Rappaport's classical lymphoma entities was found to be inhomogeneous and to include tumors of considerable prognostic heterogeneity, as shown by differences in actuarial survival. Some of the Kiel lymphoma entities have been identified in several lymphoma types of the Rappaport classification, indicating that “translation” of one scheme into the other is difficult or impossible. In addition, centrocytic lymphoma of the Kiel classification may not be homogeneous. On the whole, the Kiel classification appears to be superior to the original Rappaport classification in categorizing the various prognostically diverse types of non-Hodgkin lymphomas.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 370 (1976), S. 85-96 
    ISSN: 1432-2307
    Schlagwort(e): Malignant and benign lymphoma ; Immunocytoma ; Centroblastic malignant lymphoma ; Castleman Tumor ; Eye, lid and orbit ; Histologic features
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In der vorliegenden Studie wurden 23 Lymphome der Augen-, Lid- und Orbitalregion ausgewertet. Sie stammten aus einem nicht ausgewählten bioptischen Untersuchungsgut des Pathologischen Instituts der Universität Kiel und des Lymphknotenregisters bei der Deutschen Gesellschaft für Pathologie. Es handelte sich dabei um 12 maligne und 11 benigne Lymphome. Die malignen Lymphome stellten jeweils Non-Hodgkin-Lymphome dar. Unter den letzteren fanden wir elfmal ein Immunocytom, ein malignes Lymphom mit niedrigem Malignitätsgrad — dagegen nur einen Fall eines malignen Lymphoms mit hohem Malignitätsgrad, ein centroblastisches Lymphom. Die Diagnose eines benignen Lymphoms wurde jeweils durch die von uns erhobenen katamnestischen Angaben bestätigt. Während sich das benigne Lymphom in 7 von 11 Fällen in der Conjunctiva entwickelt hatte, war dies bei nur 2 von 11 Fällen mit Immunocytom zu beobachten. Das Immunocytom stellt einen Tumor dar, der aus Lymphocyten und Plasmazellen oder plasmocytoiden Zellen besteht und meist PAS-positive globuläre Einschlüsse in Kern und/oder Cytoplasma der Plasma- oder plasmocytoiden Zellen aufweist.
    Notizen: Summary Twenty-three lymphomas of the eye, eyelid, and orbit were chosen for study from biopsy material of the Department of Pathology, University of Kiel, and the Lymph Node Registry in Kiel. There were 12 malignant non-Hodgkin's lymphomas and 11 benign lymphomas. Catamnestic examination confirmed the histologic diagnosis in all 11 cases of benign lymphoma. Eleven of the malignant lymphomas represented immunocytomas and were therefore of low-grade malignancy. In contrast, there was only one case of malignant lymphoma of high-grade malignancy, which was diagnosed as centroblastic lymphoma. The immunocytoma was retrobulbar in one third of our cases and conjunctival in only 2 cases, whereas benign lymphoma had developed in the conjunctiva in 7 of 11 cases. Immunocytoma represents a tumor composed of lymphocytes and plasma cells or plasmacytoid cells. PAS-positive globular inclusions are usually found in the nucleus and/or cytoplasm of the plasma cells or plasmacytoid cells.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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