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  • 1
    Electronic Resource
    Electronic Resource
    The effect of methyl palmoxirate on incorporation of [U-14C]palmitate into rat brain (1994)
    Springer
    Neurochemical research 19 (1994), S. 1217-1223 
    Details
    ISSN: 1573-6903
    Keywords: Methyl palmoxirate ; palmitate ; fatty acids ; phospholipids ; brain ; rat ; in vivo imaging ; betaoxidation inhibition ; phospholipids ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the dose response, time course and reversibility of the effect of methyl 2-tetradecylglycidate (McN-3716, methyl palmoxirate or MEP), an inhibitor of β-oxidation of fatty acids, on incorporation of radiolabeled palmitic acid ([U-14C]PA) from plasma into brain lipids of awake rats. MEP (0.1, 1 and 10 mg/kg) or vehicle was administered intravenously from 10 min to 72 hr prior to infusion of [U-14C]PA. Two hr pretreatment with MEP (0.1 to 10 mg/kg) increased brain organic radioactivity 1.2 to 1.8 fold and decreased brain aqueous radioactivity by 1.2 to 3.0 fold when compared to control values. At 10 mg/kg, MEP significantly increased brain organic fraction from 40% in controls to 85%, 30 min to 6 hr pretreatment, and resulted in a redistribution of the radiolabeled fatty acid toward triacylglycerol. MEP changed the lipid/aqueous brain ratio of incorporated [U-14C]PA from 0.67 to 5.7. The incorporation rate coefficient, k*, was significantly increased by MEP (10 mg/kg) at 2 hr (31%), 4 hr (59%) and 6 hr (34%). All effects were reversed by 72 hr, consistent with a half-life of ∼2 days for carnitine palmitoyl transferase I. These results indicate that intravenous MEP may be used with [1-11C]palmitic acid for studying brain lipid metabolism in vivo by positron emission tomography, as it significantly reduces the large unincorporated aqueous fraction that would result in high background radioactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00965159
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  • 2
    Electronic Resource
    Electronic Resource
    Manoalide, a Phospholipase A2 Inhibitor, Inhibits Arachidonate Incorporation and Turnover in Brain Phospholipids of the Awake Rat (1998)
    Springer
    Neurochemical research 23 (1998), S. 1251-1257 
    Details
    ISSN: 1573-6903
    Keywords: Phospholipase A2 ; manoalide ; arachidonic acid ; phospholipids ; turnover ; inhibition ; rat ; awake ; in vivo ; fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Fatty Acid method was used to determine whether incorporation of plasma radiolabeled arachidonic acid into brain phospholipids is controlled by phospholipase A2. Awake rats received an i.v. injection of a phospholipase A2 inhibitor, manoalide (10 mg/kg), and then were infused i.v. with [1-14C]arachidonate or [3H]arachidonate. Animals were killed after infusion by microwave irradiation, and tracer distribution was analyzed in brain phospholipid, neutral lipid and acyl-CoA pools. Calcium-independent phospholipase A2 activity in brain homogenate was reduced by manoalide, whereas phospholipase C activity was unaffected. At 60 min but not at 20 or 40 min after its injection, manoalide had significantly decreased by 50% incorporation of unesterified arachidonate into and turnover within brain phospholipids, taking into account dilution of the brain arachidonoyl-CoA pool by recycled arachidonate. Manoalide also increased by 100% the net rate of unesterified arachidonate incorporation into brain triacylglycerol. This study indicates that manoalide can be used to inhibit brain phospholipase A2 in vivo, and that phospholipase A2 plays a critical role in arachidonate turnover in brain phospholipids and neutral lipids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020788031720
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  • 3
    Electronic Resource
    Electronic Resource
    Chronic Lithium Treatment Decreases Brain Phospholipase A2 Activity (1998)
    Springer
    Neurochemical research 23 (1998), S. 887-892 
    Details
    ISSN: 1573-6903
    Keywords: Lithium ; phospholipase A2 ; arachidonate ; brain ; phospholipids ; phoshatidylcholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic lithium administration decreases the turnover of arachidonic acid (AA) in several brain phospholipids. This suggests that lithium may attenuate phospholipase A2 (PLA2) activity in brain. We now report effects of chronic lithium treatment on PLA2 activity in postnuclear supernatant from rat brain: Enzyme activity was determined by two assay methods, radiometric and fluorometric, and measured the release of the fatty acid on the second acyl position (sn2) from choline and ethanolamine phospholipids. PLA2 activity in brain postnuclear supernatant from rats chronically treated with lithium in the diet was significantly decreased (20–50%) when compared with controls. In vehicle or lithium-treated rats, PLA2 activity was not significantly augmented or attenuated by the addition of calcium chelators, divalent cations or LiCl supplementation (1.0 mM) to postnuclear supernatant. These results suggest that a major therapeutic effect of lithium is to attenuate brain PLA2 activity involved in signal transduction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022415113421
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  • 4
    Electronic Resource
    Electronic Resource
    Darstellung und physikalische Eigenschaften mesoionischer 1,3-Dithiolone1) (1976)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 109 (1976), S. 740-752 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Physical Properties of Mesoionic 1,3-Dithiolones1)1,3-Dithiolylium-4-olates 3a-1 are preparatively interesting mesoionic 6π Arenes. Their synthesis from the corresponding dithioester derivatives 1a-1 and their infrared, electronic, and mass spectra are described. 3a, b, and f possess as sydnone analogues compounds relatively high dipole moments of 5.00, 5.54, and 5.98 D, respectively.
    Notes: 1,3-Dithiolylium-4-olate 3a-1 sind präparativ interessante mesoionische 6π-Aromaten. Ihre Synthese aus den entsprechenden Dithiocarbonester-Derivaten 1a-1 sowie Infrarot-, Elektronen- und Massenspektren werden beschrieben. Als Sydnon-Analoga besitzen 3a, b und f relativ große elektrische Momente von 5.00, 5.54 bzw. 5.98 D.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19761090235
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  • 5
    Electronic Resource
    Electronic Resource
    The electronic structure of phosphorus cages with the nortricyclane skeleton. - Model calculations and photoelectron spectroscopic investigations (1983)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 116 (1983), S. 2972-2982 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Die Elektronenstruktur von Phosphor-Verbindungen mit Nortricyclan-Struktur. - Modell-Rechnungen und PhotoelektronenspektrenDie unterschiedliche Reaktivität der Phosphor-Verbindungen P4[Si(CH3)2]3 (1) and P7(CH3)3 (2) wird anhand eines einfachen MO-Schemas diskutiert. Das MO-Schema basiert auf semiempirischen Rechnungen (MINDO/3, MNDO) und auf He(1)-photoelektronenspektroskopischen Untersuchungen an 1 und 2. Die Elektronenstruktur ähnlich gebauter Käfigverbindungen mit Nortricyclangerüst wie P73-, P4S3 und P7[Si(CH3)3]3 wird mit 1 und 2 verglichen.
    Notes: The different reactivity of P4[Si(CH3)2]3 (1) and P7(CH3)3 (2) is discussed in terms of a simple MO scheme. This scheme is based on semiempirical calculations (MINDO/3, MNDO) and on He(1) photoelectron spectroscopic investigations on 1 and 2. The electronic structure of similar cage compounds with the nortricyclane skeleton like P73-, P4S3, and P7[Si(CH3)3]3 is compared with 1 and 2.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19831160823
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  • 6
    Electronic Resource
    Electronic Resource
    Die Elektronenstruktur und das He(I)-Photoelektronen-Spektrum von (Cyclopentadienyl)(1,4-dimethyl-1,4-dibora-2,5-cyclohexadien)cobalt (1982)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 115 (1982), S. 754-763 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The Electronic Structure and the He(I) Photoelectron Spectrum of (Cyclopentadienyl)(1,4-dimethyl-1,4-dibora-2,5-cyclohexadiene)cobaltThe electronic structure of (cyclopentadienyl)(1,4-dimethyl-1,4-dibora-2,5-cyclohexadiene)cobalt (1) has been investigated by means of semiempirical INDO calculations and by means of the He(I) photoelectron (PE) spectroscopy. The cyclopentadienyl ligand is bonded due to Co 3dyz to the transition metal center, while the dibora system is coupled via 3dxz to the Co atom. In the electronic groundstate several ligand orbitals are predicted on top of the Co 3d valence orbitals. Strong reorganization effects of the Co 3d levels during the ionization cause a switch of the groundstate orbital sequence. The first PE bands are due to Co 3d orbitals. By means of perturbational calculations based on the Green's function approach it is possible to reproduce the experimental PE spectrum with sufficient accuracy.
    Notes: Die Elektronenstruktur von (Cyclopentadienyl)(1,4-dimethyl-1,4-dibora-2,5-cyclohexadien)cobalt (1) wurde mit Hilfe von semiempirischen INDO-Rechnungen sowie He(I)-Photoelektronen(PE)-Spektrum untersucht. Der Cyclopentadienyl-Ligand wird durch Co-3dyz an das Zentralatom gebunden, während das Dibor-System über 3dxy an Co gekoppelt wird. Im elektronischen Grundzustand liegen mehrere Ligandenniveaus oberhalb der Co-3d-Valenzorbitale. Bei der Ionisation führen starke Reorganisationseffekte innerhalb der Co-3d-Orbitale zu einer Vertauschung der Orbitalsequenz des Grundzustands; die ersten PE-Banden werden durch Co-3d-Niveaus hervorgerufen. Durch störungstheoretische Rechnungen, die auf dem Formalismus der Greenschen Funktion beruhen, läßt sich das gemessene PE-Spektrum theoretisch gut reproduzieren.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19821150236
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  • 7
    Electronic Resource
    Electronic Resource
    Ein neuer präparativer Zugang zu Thiophen-Derivaten durch thermische [3 + 2]-Cycloadditionen mesoionischer 1,3-Dithiolone and Alkine1) (1976)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 109 (1976), S. 753-760 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: A New Preparative Entry to Thiophene Derivatives by Way of Thermal [3 + 2] Cycloaddition Reactions of Mesoionic 1,3-Dithiolones to AlkynesAs cyclic thiocarbonyl ylids the 1,3-dithiolylium-4-olats 1a-jcombine in 2,5-position at 90-130°C with dimethyl acetylenedicarboxylate with formation of non-isolable primary adducts of type 2. The latter fragment with fast evolution of carbon oxisulfide to give the thiophene diesters 3a, b, d, f, h-j in 67-100% yield. The analogous cycloaddition reactions of 1a with propiolic ester, phenylpropiolic ester, acetyl phenylacetylene, benzoyl phenylacetylene and phenylacetylene yield the thiophene derivatives 6-10.
    Notes: Die 1,3-Dithiolylium-4-olate 1a-j nehmen als cyclische Thiocarbonyl-ylide in 2.5-Stellung bei 90-130°C Acetylendicarbonester unter Bildung nicht isolierbarer Primäraddukte vom Typ 2 auf. Diese zerfallen rasch unter Kohlenoxysulfid-Abspaltung in 67-100proz. Ausbeute zu den Thiophen-dicarbonestern 3a, b, d, f, h-j. Die analogen Cycloadditionen von 1a an Propiolester, Phenylpropiolester, Acetylphenylacetylen, Benzolylphenylacetylen bzw. Phenylacetylen ergeben die Thiophen-Derivate 6-10.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19761090236
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  • 8
    Electronic Resource
    Electronic Resource
    Die He(I)-Photoelektronenspektren von Tetracarbonyleisen(0)-Komplexen mit Carbenen (1980)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 113 (1980), S. 3629-3646 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The He(I) Photoelectron Spectra of Tetracarbonyliron(l0) Complexes with CarbenesThe He(I) photoelectron(PE) spectra of the tetracarbonyl(carbene)iron(0) complexes 1-3 have been recorded. The first six bands were assigned by calculating the different ionic states separately (ΔSCF procedure) or by using the „Transition Operator Model“. It is found that the Koopmans′ defects for the orbitals localized at the iron are larger than for orbitals localized at the ligands.
    Notes: Die He(I)-Photoelektronen(PE)-Spektren der Tetracarbonyl(carben)eisen(0)-Komplexe 1-3 wurden gemessen. Die Zuordnung der ersten sechs Banden basiert auf der Berechnung der verschiedenen Kationenzustände mittels der ΔSCF-Methode und mit Hilfe des „Transition Operator“-Modells. Für die Orbitale, die hauptsächlich am Metall lokalisiert sind, werden größere Koopmans-Defekte gefunden als für die an den Liganden lokalisierten Orbitale.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19801131121
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  • 9
    Electronic Resource
    Electronic Resource
    Die He(I)-Photoelektronenspektren von Bis(1,3-dien)monocarbonyleisenkomplexen (1980)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 113 (1980), S. 3647-3655 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The He(I) Photoelectron Spectra of Bis(1,3-diene)monocarbonyliron ComplexesThe He(I) photoelectron (PE) spectra of the bis(1,3-diene)monocarbonyliron complexes 1 to 3 have been recorded. The assignment of the first seven bands is based on INDO calculations using the ΔSCF procedure and the „transition operator“ model. The bonding properties for the ground state of 1 are discussed.
    Notes: Die He(I)-Photoelektronen(PE)-Spektren der Bis(1,3-dien)monocarbonyleisenkomplexe 1 bis 3 wurden gemessen. Die Zuordnung der ersten sieben Banden resultiert aus der Berechnung der verschiedenen Kationenzustände mittels der ΔSCF-Methode und des „Transition Operator„-Modells, basierend auf einem INDO-Verfahren. Die Bindungsverhältnisse im Grundzustand von 1 werden diskutiert.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19801131122
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  • 10
    Electronic Resource
    Electronic Resource
    Das He(I)-Photoelektronenspektrum von 1,2,6,7-Cyclodecatetraen. Hinweis auf eine starke transannulare Wechselwirkung (1978)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 111 (1978), S. 3516-3518 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The He(I) Photoelectron Spectrum of 1,2,6,7-Cyclodecatetraene. Evidence for a Strong Transannular InteractionThe photoelectron spectrum (He(I)) of 1,2,6,7-cyclodecatetraene (3) is discussed. The first four bands in the PE spectrum of 3 are assigned by comparison with calculated orbital energies according to MINDO/3. The interaction between both allenic units can be described by the interaction parameters β = -0.58 eV and β′ = -0.07 eV.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19781111028
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