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  • 1
    Electronic Resource
    Electronic Resource
    Relationship between the degree of injury at operation and the change in antimyosin antibody titer in the postpericardiotomy syndrome (1994)
    Springer
    Pediatric cardiology 15 (1994), S. 116-120 
    Details
    ISSN: 1432-1971
    Keywords: Antimyosin antibody titer ; Cardiac myosin light chain I ; Creatine kinase isoenzyme MB ; Postpericardiotomy syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Successive measurements of cardiac myosin light chain I (MLC), creatine kinase isoenzyme MB (CKMB), and the titer of antimyosin antibody (AMA) were performed prospectively in 19 patients following open heart surgery. Seven of these patients showed the postpericardiotomy syndrome (PPS). No differences in serum concentrations of MLC or CKMB were observed between the patients with and without PPS, and all patients in both groups had abnormal MLC values after surgery. However, only patients with PPS had significantly elevated AMA titers. The maximum AMA titer was significantly correlated with the severity of the effusion. These data suggest that PPS is unrelated to the severity of myocardial injury during operation. Furthermore, the AMA titer may be useful as one of the indicators for determining the patient's clinical condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00796322
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  • 2
    Electronic Resource
    Electronic Resource
    Twenty-five types of T-cell receptor Vβ family repertoire in patients with Kawasaki syndrome (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 981-986 
    Details
    ISSN: 1432-1076
    Keywords: Key words Kawasaki syndrome ; Superantigen ; Reverse transcription PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently, a possible relationship between Kawasaki syndrome (KS) and superantigen has been discussed since the report of selective expansion of specific Vβ family in the acute phase of KS. To further investigate the relationship between KS and superantigens, we examined 25 types of T-cell receptor Vβ family repertoire in patients with KS using the reverse transcription polymerase chain reaction. This is the first attempt to examine all of 25 Vβ families in KS. A non radioisotope method was used to quantify mRNA so that the experiment was safer, simpler, and faster. An expression index (EI) for each Vβ was defined as: (the amount of each Vβ mRNA)/(the sum of all Vβ mRNA) × 100. Ten patients with KS and ten normal children were studied. The Vβ9 and Vβ15 of acute phase of KS showed both significantly lower mean EI and significantly higher frequency of a decreased EI value as compared with control children. Selective expansion of the Vβ family in the patients with KS was not observed. Although highly increased EIs were observed in various Vβs, their frequency was not statistically significant. The pattern of increased Vβs did not show the specific pattern that indicates a particular superantigen. Conclusion In Kawasaki syndrome non-radioisotope method for analysing Vβ mRNA is useful in cases where many samples have to be handled. The depletion of Vβ9 and Vβ15 or highly increased expression index in the acute phase of Kawasaki syndrome might suggest a relationship to superantigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050982
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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