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  • Proton magnetic resonance spectroscopy  (2)
  • brain oedema  (2)
  • NMR  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography (1995)
    Springer
    Neuroradiology 37 (1995), S. 198-206 
    Details
    ISSN: 1432-1920
    Keywords: Key words Gliomas ; Proton magnetic resonance spectroscopy ; Proton magnetic resonance spectroscopic imaging ; Brain oedema ; Positron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 32 patients with gliomas, one- and two-dimensional proton magnetic resonance spectroscopy (1H-MRS) has been conducted, the latter allowing reconstruction of spectroscopic data into a spectroscopic image (MRSI), showing the distribution of the various metabolite concentrations over the cross-sectional plane. For lack of absolute concentrations, the measured concentrations of phosphocholine (CHOL), N -acetyl-L-aspartate (NAA), and lactate (LAC) were conventionally expressed in ratios relative to that of creatine (CREAT). Compared to normal brain tissue, an increased CHOL/CREAT ratio was found in all groups of tumours, in glioblastomas, high-, middle- and low-grade astrocytomas both at the margin and the core of the tumours, but in oligodendrogliomas only at the margin. This is consistent with an increased phosphocholine turnover in relation to membrane biosynthesis by the proliferating cells. The NAA/CREAT ratio was decreased in all groups of tumours, both in the centre and at the margin, reflecting replacement of functioning neurons by neoplastic cells. The LAC/CREAT ratio was elevated in the core of malignant gliomas, which may be the result of a prevailing glycolysis, characteristic of tumours, possibly in conjunction with hypoxia/ischaemia. In the perifocal oedema, there was neither elevation of the CHOL/CREAT ratio nor decrease of the NAA/CREAT ratio; an increased LAC/CREAT ratio therefore rather reflected ischaemia/hypoxia probably due to locally elevated pressure and compromised regional perfusion. In the normal brain, the metabolite ratios of grey matter did not differ from those of white matter. The frontal lobe and basal ganglia showed lower NAA/CREAT ratios than the other cerebral areas. In 7 patients positron emission tomography was also performed with [18F]fluoro-2-deoxy-D-glucose (18FDG) or L-[1-11C]-tyrosine (11C-TYR); the latter demonstrated a pattern of 11C-TYR uptake similar to that of CHOL elevation in the MRSI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01578258
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography (1995)
    Springer
    Neuroradiology 37 (1995), S. 198-206 
    Details
    ISSN: 1432-1920
    Keywords: Gliomas ; Proton magnetic resonance spectroscopy ; Proton magnetic resonance spectroscopic imaging ; Brain oedema ; Positron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 32 patients with gliomas, one- and two-dimensional proton magnetic resonance spectroscopy (1H-MRS) has been conducted, the latter allowing reconstruction of spectroscopic data into a spectroscopic image (MRSI), showing the distribution of the various metabolite concentrations over the cross-sectional plane. For lack of absolute concentrations, the measured concentrations of phosphocholine (CHOL),N-acetyl-L-aspartate (NAA), and lactate (LAC) were conventionally expressed in ratios relative to that of creatine (CREAT). Compared to normal brain tissue, an increased CHOL/CREAT ratio was found in all groups of tumours, in glioblastomas, high-, middle- and low-grade astrocytomas both at the margin and the core of the tumours, but in oligodendrogliomas only at the margin. This is consistent with an increased phosphocholine turnover in relation to membrane biosynthesis by the proliferating cells. The NAA/CREAT ratio was decreased in all groups of tumours, both in the centre and at the margin, reflecting replacement of functioning neurons by neoplastic cells. The LAC/ CREAT ratio was elevated in the core of malignant gliomas, which may be the result of a prevailing glycolysis, characteristic of tumours, possibly in conjunction with hypoxia/ischaemia. In the perifocal oedema, there was neither elevation of the CHOL/CREAT ratio nor decrease of the NAA/CREAT ratio; an increased LAC/CREAT ratio therefore rather reflected ischaemia/hypoxia probably due to locally elevated pressure and compromised regional perfusion. In the normal brain, the metabolite ratios of grey matter did not differ from those of white matter. The frontal lobe and basal ganglia showed lower NAA/CREAT ratios than the other cerebral areas. In 7 patients positron emission tomography was also performed with [18F]fluoro-2-deoxy-D-glucose (18FDG) or L-[1-11C]-tyrosine (11C-TYR); the latter demonstrated a pattern of11C-TYR uptake similar to that of CHOL elevation in the MRSI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01578258
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    On the principles underlying the diagnosis of brain tumours — A survey article (1995)
    Springer
    Acta neurochirurgica 135 (1995), S. 1-11 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumour ; brain oedema ; blood brain barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A survey is given of the principles underlying the diagnosis of brain tumours. Traditionally diagnosis and localization of brain tumours have been based upon morphological criteria. Currently unsurpassed levels in imaging of anatomical details and topographical relations by the techniques of computed tomography (CT) and magnetic resonance imaging (MRI) have been achieved. The techniques of positron emission tomography (PET) and of magnetic resonance spectroscopy (MRS), which depict also metabolic and blood flow aspects, provide a refinement of our knowledge on the metabolism, structure and pathophysiological relations of a tumour to the surrounding parenchyma. Recent advances in the recording of function-related changes of the cerebral electro-magnetic field allow a better definition of critical functional areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02307407
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Positron emission tomographical studies of 1-11C-acetoacetate, 2-18F-fluoro-deoxy-D-glucose, and L-1-11C-tyrosine uptake by cat brain with an experimental lesion (1989)
    Springer
    Acta neurochirurgica 99 (1989), S. 166-172 
    Details
    ISSN: 0942-0940
    Keywords: Positron emission tomography ; 18F-fluorodeoxyglucose ; ketone bodies ; 11C-tyrosine ; brain oedema ; blood-brain barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In cat brain with a freezing injury, the uptake of 1-11C-acetoacetate (11C-ACAC), 2-18F-fluorodeoxy-D-glucose (18FDG), and L-1-11C-tyrosine (11C-TYR) was monitored by positron emission tomography following intravenous administration of the tracers, at 1 day and 1–3 weeks after the injury. The development and further course of the cold-induced oedema was monitored by magnetic resonance imaging. In the fresh (1 day old) lesion there was increased uptake of11C-ACAC, probably due to release of the restrictive influence of the blood-brain barrier upon passage of the substance into brain. The uptake of18FDG, which normally occurs by carrier-mediated transport at the barrier, was decreased in the fresh lesion, probably as a result of damage of the carrier mechanism. In the 3 week old lesion18FDG uptake was still reduced, and11C-ACAC uptake was still increased, although barrier function to Evans blue had recovered. It is suggested, that the increased11C-ACAC uptake in the chronic lesion bears upon the proliferation of macrophages and reactive glial cells in the lesion. This is supported by the increased uptake of11C-TYR in the 2 weeks old lesion, while in the fresh lesion11C-TYR uptake was unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402328
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A comparison of the sensitivity of PET and NMR for in vivo quantitative metabolic imaging (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 73-75 
    Details
    ISSN: 1619-7089
    Keywords: Metabolic imaging ; PET ; NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using positron emission tomography (PET) in combination with compounds labelled with positron-emitting radionuclides like 11C, 13N and 15O, it is possible to study metabolism in vivo in a non-invasive way. Nuclear magnetic resonance (NMR) imaging takes advantage of the spin of protons in water molecules to measure both their number and relaxation times in vivo, but is, in principle, not limited to protons and can also be used for other nuclei with a non-zero spin, e.g. 13C and 31P. The use of 13C opens the possibility of studying the metabolism of a large number of compounds. In order to choose the appropriate methodology for metabolic imaging, i.e. PET or NMR, it is important to know the sensitivity of each modality. The present study outlines the sensitivity of both techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252137
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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