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  • 1
    Electronic Resource
    Electronic Resource
    Quantification of the whole-body distribution of PET radiopharmaceuticals, applied to 3-N-([18F]fluoroethyl)spiperone (1990)
    Springer
    European journal of nuclear medicine 16 (1990), S. 77-83 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography-D2 receptor ; 3-N-([18F]Fluoroethyl)spiperone (FESP) ; Radiation dosage ; Biodistribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using a multi slice whole body PET scanner PC4096-15WB, diagnostic measurements of the cerebral distribution of the D2 receptor ligand 3-N-([18F]fluoroethyl)spiperone were extended to quantify the biodistribution of this PET radiopharmaceutical. As a rotating line source was used for measured attenuation correction, transmission scans could be combined with emission scans even after injection of the tracer. Only 1 of the total administered dose (TAD) was found in the whole brain at 180 min, but the striatum and pituitary were still excellently delineated. Urinary bladder, gall bladder, and liver were the organs with the highest TAD ranging from 6% to 25%. The gall bladder is the critical organ with an absorbed dose of about 200 mGy/kBq followed by the urinary bladder and liver with 83 and 66 mGy/kBq, respectively. In the rest of the body radioactivity was evenly distributed. The total body dose was found to be 11.9 mGy/kBq.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01465913
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  • 2
    Electronic Resource
    Electronic Resource
    PET radiopharmaceuticals in Europe: Current use and data relevant for the formulation of summaries of product characteristics (SPCs) (1995)
    Springer
    European journal of nuclear medicine 22 (1995), S. 1420-1432 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; PET ; Radiopharmaceuticals ; Quality criteria ; Toxicology ; Dosimetry ; Survey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task group for licensing PET radiopharmaceuticals; this group has surveyed the use of these compounds in Europe by a questionnaire. The number of PET centres that responded to the questionnaire was 26, which included more than 90% of the larger European PET centres. The survey showed that 2-[18F]fluoro-2-deoxyglucose is by far the most important PET radiopharmaceutical with more than 200 applications per week, followed by [15O]water, [15O]carbonmonoxide, [13N]ammonia, [11C]-l-methionine, andl-6-[18F]fluoro-DOPA. More than 25 other PET radiopharmaceuticals are in regular use, however, at rather low application frequencies. The data were used by the European Pharmacopoeia Commission for its priority rating for requesting the formulation of monographs. Since it is likely that group registrations will be issued by authorities for the PET radiopharmaceuticals, relevant data on toxicity and dosimetry for the formulation of summaries of product characteristics have been collected by the task group as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01791152
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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