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  • 1
    Electronic Resource
    Electronic Resource
    Inflammation-induced increase in the density of neuropeptide-immunoreactive nerve endings in rat skeletal muscle (1998)
    Springer
    Experimental brain research 121 (1998), S. 174-180 
    Details
    ISSN: 1432-1106
    Keywords: Key words Substance P ; Nerve growth factor ; Growth-associated protein 43 ; Nerve endings ; Myositis ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The density of substance P (SP)-, calcitonin gene-related peptide (CGRP)- and vasoactive intestinal polypeptide (VIP)-immunoreactive (ir) nerve endings was quantitatively evaluated in intact and inflamed gastrocnemius-soleus muscle of the rat. In persistently inflamed muscle (12 days after a single injection of Freund’s adjuvant into the muscle), the density of SP-ir fibres was significantly increased. CGRP- and VIP-ir fibres displayed an insignificant increase in density. The density of fibres ir for nerve growth factor (NGF) and for growth-associated protein 43 (GAP-43/B-50), a marker for axonal sprouting, regeneration and synaptic reorganisation, increased significantly in persistently inflamed muscle. The data are consistent with the established contribution of NGF on the expression of SP and GAP-43 in afferent neurones under the influence of a persistent inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050449
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of mechanical stimuli and of acetylsalicylic acid on the discharges of slowly conducting afferent units from normal and inflamed muscle in the rat (1993)
    Springer
    Experimental brain research 92 (1993), S. 431-440 
    Details
    ISSN: 1432-1106
    Keywords: Inflammation ; Muscle pain ; Slowly conducting muscle afferents ; Sensitization ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anaesthetized rats, the influence of an experimental inflammation and of acetylsalicylic acid (ASA) on the discharge properties of muscle receptors with slowly conducting afferent fibres was studied using a single-fibre recording technique. Following the induction of a myositis with carrageenan, the proportion of units having background activity and the frequency of the background discharge were significantly increased. The latter change was particularly prominent in high-threshold mechanosensitive (HTM) units. There was evidence for an inflammation-induced lowering of mechanical threshold in HTM units, but the change was not statistically significant. Administration of ASA intravenously led to a decrease in the frequency of background discharge in some units while others were unaffected, although they appeared to be sensitized by the inflammation. If one assumes that at least some of the HTM receptors fulfil nociceptive functions, the results suggest that the pain and tenderness of an inflamed muscle is largely due to a sensitization and hence increased activity of nociceptive muscle receptors. The sensitization is only partially abolished by ASA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229031
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    Paper (German National Licenses)
    Fulltext
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