ISSN:
1439-1104
Keywords:
philanthotoxins
;
patch clamp
;
locust muscle
;
ionotropic glutamate receptor
;
intracellular injection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The effects of intracellularly-applied philanthotoxin-343 (PhTX-343) on single channel currents gated by quisqualate-sensitive glutamate receptors (qGluR) of locust leg muscle have been studied. PhTX-343 initially increased qGluR channel open probability, mainly by virtue of an increase in mean channel open time, but this was followed by a decrease in channel open probability, sometimes to zero, because of a decline in the frequency of channel openings and a decline in mean channel open time. These results suggest that antagonism of qGluR by PhTX-343 can arise, in part, through binding of the toxin to a site or sites on the intracellular domain of this receptor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02211935
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