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  • 1
    Electronic Resource
    Electronic Resource
    Management of arrhythmias in hypertrophic cardiomyopathy (1994)
    Springer
    Cardiovascular drugs and therapy 8 (1994), S. 95-99 
    Details
    ISSN: 1573-7241
    Keywords: hypertrophic cardiomyopathy ; arrhythmias ; ventricular tachycardia ; sudden death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the management of hypertrophic cardiomyopathy the goals should be the control of symptoms, and the identification and treatment of those at high risk. Arrhythmias, particularly atrial fibrillation and nonsustained ventricular tachycardia, are common in adult patients with hypertrophic cardiomyopathy. Atrial fibrillation has long been thought to herald an ominous prognosis, but this is probably not the case, and in the majority of patients atrial fibrillation can be controlled without accelerated symptomatic deterioration. Uncontrolled observations indicate that low-dose amiodarone may be the most useful drug in both paroxysmal and chronic atrial fibrillation. The detection of nonsustained ventricular tachycardia on ambulatory ECG monitoring remains the single most useful indicator of the risk of sudden death in the adult patient, and the treatment of choice is again low-dose amiodarone. The mechanism of sudden death, and the mode of action of amiodarone in preventing it, are not known for certain in the majority of patients. The risk of sudden death is higher in children and adolescents, but arrhythmias are less common, and no useful predictive marker of increased risk has been found. The roles of invasive electrophysiological studies and the implantable cardioverter-defibrillator are still being evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877095
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Measurement of left ventricular heat production in man (1991)
    Springer
    Medical & biological engineering & computing 29 (1991), S. 149-154 
    Details
    ISSN: 1741-0444
    Keywords: Cardiac energetics ; Coronary sinus flow ; Error analysis ; Left ventricular mechanical efficiency ; Thermodilution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A system to measure left ventricular heat productionΦ Iv in conscious human subjects is described. UsingΦ Iv and the rate of energy supply to the myocardium, the mechanical efficiency of the left ventricle is calculated. Heat carriage in left ventricular myocardial blood flowΦ CS is calculated from coronary sinus flow and the transcoronary temperature difference. Diffusional heat lossΦ diff is derived from the ratio of areas under temperature/time curves recorded in the aorta and coronary sinus after a bolus injection of cold saline into the pulmonary artery. The sum ofΦ cs andΦ diff (the energy of endothermic reactions with haemoglobin) givesΦ Iv . The estimated errors in the derived values of heat production and mechanical efficiency are less than 17 per cent. At basal heart rates 17 patients with good left ventricular function had a transcoronary temperature difference of 0·16±0·03°C (mean ± standard deviation), left ventricular flow blood flow of 145·3±81·5 ml min−1, andΦ Iv of 3·1±1·8 W. Left ventricular oxygen extraction was strongly correlated withΦ Iv (r=0.925, p〈0·001). Left ventricular mechanical efficiency was 0·33±0·11, at basal heart rates, which fell to 0·18±0·15 (p〈0·001) on atrial pacing at 100 beats min−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447100
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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