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  • indoles  (4)
  • pteridines  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Age-dependent effects of 5-methoxytryptophol and melatonin on testes and comb growth of the white leghorn (Gallus Domesticus L.) (1972)
    Springer
    Journal of neural transmission 33 (1972), S. 179-194 
    Details
    ISSN: 1435-1463
    Keywords: Pineal ; indoles ; gonads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Testes weights of white leghorns of the same age or of equal body weight vary considerably. Experiments on the effects of pinealectomy, administration of pineal extracts or indolic compounds on the testes weights therefore require better parameters. Cockerels having a similar initial comb size prove to have testes of similar weights. Experiments using this parameter permit a more exact comparison of control and experimental animals. Administration of 5-methoxytryptophol and melatonin in increasing concentrations to juvenile, maturing and adult white leghorn males shows an age-dependent activity. In juvenile birds, the testes and comb growth are stimulated by 5-methoxytryptophol and melatonin, whereas in maturing and adult cocks both indolic compounds show an inhibitory effect. It appears that the effect of 5-methoxytryptophol is more specific than that of melatonin in juvenile as well as in maturing and adult white leghorns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245316
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of some pteridines on pineal 5-methoxyindole synthesis in male Wistar rats periodically exposed to either white or green light (1983)
    Springer
    Journal of neural transmission 58 (1983), S. 121-134 
    Details
    ISSN: 1435-1463
    Keywords: Pineal ; melatonin/5-methoxytryptophol ; 5-methoxyindoles ; pteridines ; green light
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pineals of 28 days old male Wistar rats, in December periodically exposed to either white or green light, were incubated with pterin-6-aldehyde or reduced neopterin. In white light the rhythm of synthesis of 5-methoxytryptophan and of 5-methoxyindole-3-acetic acid was clearly influenced by the pteridines mentioned. In green light a change in rhythmicity of 5-methoxytryptophan, 5-methoxytryptamine and of melatonin/5-methoxytryptophol synthesis by the pteridines was observed. In white light both pteridines increased 5-methoxytryptophan and decreased 5-methoxyindole-3-acetic acid synthesis. Reduced neopterin stimulated 5-methoxytryptamine synthesis and inhibited melatonin/5-methoxytryptophol synthesis. Pterin-6-aldehyde showed an opposite effect. In green light both pteridines decreased 5-methoxytryptophan synthesis, but increased 5-methoxyindole-3-acetic acid and 5-methoxytryptamine synthesis. Melatonin/5-methoxytryptophol synthesis was decreased by reduced neopterin and increased by pterin-6-aldehyde. The results suggest an indolic metabolic pathway leading from 5-methoxytryptophan via 5-methoxytryptamine to melatonin, while pteridines and light of different wave lengths are correlated in regulating indole metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249130
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of melatonin and other indole derivatives in maintaining ovulation in rats kept in continuous light and the influence of these indoles on HIOMT activity in the pineal gland (1982)
    Springer
    Journal of neural transmission 53 (1982), S. 305-314 
    Details
    ISSN: 1435-1463
    Keywords: Pineal gland ; continuous light ; ovulation ; indoles ; melatonin ; HIOMT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the present study was to investigate whether the ovulation-maintaining effect of melatonin in rats, exposed to continuous light (LL), was also exerted by other pineal indoles which have been reported to influence the reproductive processes of mammals. The effect of 10μg melatonin was compared with that of similar amounts of either N-acetylserotonin, 5-methoxytryptophol, 5-methoxyindole-3-acetic acid, 5-hydroxytryptophol, 5-methoxytryptamine or 5-methoxytryptophan. All these compounds appeared to be significantly less effective than melatonin in preventing the effect of LL, ovulation being preserved in only 20–33 % of the rats investigated, with melatonin this percentage being 60–75%. Investigations were also carried out to assess the effect of these indole derivatives on HIOMT (hydroxyindole-O-methyl transferase) activity in synthesizing different 5-methoxyindoles in the abnormally influenced pineal gland due to LL. Melatonin, the compound the effect of which on ovarian cyclicity is strongest, stimulates 5-methoxytryptophol synthesis; while other less active compounds stimulate the synthesis of melatonin and inhibit that of O-acetyl-5-methoxytryptophol. The possibility that the effect of other indoles than melatonin on ovarian cyclicity might be due to stimulation of melatonin synthesis was considered. A possible functional relationship of the different indoles cannot be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01252041
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of some pteridines on pineal 5-methoxy-indole synthesis in male wistar rats periodically exposed to either white or red light (1983)
    Springer
    Journal of neural transmission 56 (1983), S. 199-210 
    Details
    ISSN: 1435-1463
    Keywords: Pineal ; melatonin/5-methoxytryptophol ; 5-methoxyindoles ; pteridines ; red light
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In previous investigations the change of circadian rhythmicity in pineal melatonin/5-methoxytryptophol synthesis of rats periodically exposed to red light was similar to that in pineals of rats incubated with pterin-6-aldehyde. These experiments were, however, performed with rats of different age and in different periods of the year. In the present study these two factors influencing pineal indole metabolism have been combined the experiments being carried out in rats aged 28 days and during the same day in the month of January. It was observed that under influence of red light the peak of melatonin/5-methoxytryptophol synthesis shifted towards daytime, whereas incubation with pterin-6-aldehyde did not cause such a shift. If under different experimental conditions the mean amount of melatonin/5-methoxytryptophol which was formed over a 24 hour period was compared, it appeared that pineals of rats exposed to white light incubated with reduced neopterin but not pineals incubated with pterin-6-aldehyde behave in this respect similar to pineals of rats exposed to red light. However, if the ratio between melatonin/5-methoxytryptophol and 5-methoxytryptamine is calculated pineals of white light exposed rats incubated in pterin-6-aldehyde behaved very similar to the pineals of rats exposed to red light. Although the role of pteridines remains obscure, it appears that the parameters 1. circadian rhythmicity and 2. the amount of 5-methoxyindoles and 3. the ratio between these indole derivatives might be of importance in analyzing their physiological effects. The influence of application of light of different wavelenghts and year rhythmicity is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243278
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The inhibitory effect of 5-methoxytryptophol on ovarian weight, follicular growth and egg production of adult white leghorn hens (Gallus domesticus L.) (1973)
    Springer
    Journal of neural transmission 34 (1973), S. 159-169 
    Details
    ISSN: 1435-1463
    Keywords: Pineal ; indoles ; gonads ; chick
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Identical age, body weight, or initial comb size are not useful as parameters in analysing effects of pineal substances on the gonadal system of adult white leghorn hens. A combination, however, of the initial comb size with the frequency of oviposition proved to be an adequate parameter. Administration of 5-methoxytryptophol in increasing concentrations to adult hens shows an inhibitory effect on ovarian and follicular weight. This effect is not only realized by a decrease in organ weight, but also by a retardation of the rhythm as expressed in initial comb size units. As follicular growth is mainly dependent on a FSH/LH ratio in which the LH content is increased, the inhibitory effect may possibly be described to this relation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244669
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  • 6
    Electronic Resource
    Electronic Resource
    The stimulatory effects of several concentrations of 5-methoxytryptophol on testicular growth in the white leghorn (Gallus domesticus L.) (1973)
    Springer
    Journal of neural transmission 34 (1973), S. 49-60 
    Details
    ISSN: 1435-1463
    Keywords: Pineal ; indoles ; gonads ; chick
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concerning the gonads, the initial comb size in white leghorn cockerels proved to be a parameter which permits a more exact comparison of control and experimental animals, than the generally used parameters of identical age and/or body weight. As in literature contradictory results are described after injecting different concentrations of 5-methoxyindoles, it may be possible that these results can be explained by the parameters used. To analyse this, several concentrations of 5-methoxytryptophol were injected in increasing amounts in white leghorn cockerels, using the comb size as a parameter. In all experiments a stimulatory effect of 5-methoxytryptophol on testicular weight was observed. Administration of the smallest concentrations (0.1–3.5μg, exp. I, and 1.0–35μg, exp. II) showed an acceleration of the growing rhythm of the testes if compared with the control animals. With the comb size as a parameter it was possible to analyse the degree of stimulation in comb size units. Administration of 2.5–87.5μg (exp. III) and of 10–350μg (exp. IV) of 5-methoxytryptophol resulted also in a stimulatory activity on testicular growth; acceleration of the growing rhythm, however, now proved to be irregular and could not be compared with the growing pattern of the testes in the control animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244826
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    Paper (German National Licenses)
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