Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Modification of the effect of some central stimulants in mice pretreated with α-methyl-l-tyrosine (1967)
    Springer
    Psychopharmacology 10 (1967), S. 437-444 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In mice treated with α-methyltyrosine (AMT) so as to deplete the brain norepinephrine by 65 percent of the normal, the central stimulant effects of d-amphetamine, morphine, mescaline and cocaine were significantly reduced. The effects were evaluated by observing the spontaneous motor activity, the degree of eye closure and rectal temperature of mice. The hypermotility and hyperthermia caused by lysergic acid diethylamide remained unaffected by AMT treatment. Desmethylimipramine failed to antagonize the sedation produced by repeated doses of AMT which lowered brain norepinephrine by 95 percent. These results showed that except that of lysergic acid diethylamide, the central stimulant effects of other drugs and the antidepressant effect of desmethylimipramine were mediated through norepinephrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403985
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    A comparative study of d- and l-amphetamine on the open field performance of rats (1974)
    Springer
    Psychopharmacology 39 (1974), S. 67-70 
    Details
    ISSN: 1432-2072
    Keywords: Horizontal Stereotypy ; Vertical Stereotypy ; d- and l-Amphetamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Behavioural effects in the Open Field test following the administration of d- and l-amphetamine were compared in rats. A significant difference was found between the effects of the two isomers on horizontal activity, d-amphetamine alone causing horizontal stereotypy. In both cases dose-response relations were curvilinear. On the other hand, although both isomers produced vertical stereotypy, the dose-response relations were generally monotonic increasing with no signifiacnt differences between isomers. These differential effects on behaviour have been explained on the basis of stereospecificity of adrenergic neurons for amphetamine. The results of the study are consistent with earlier hypotheses that the horizontal and vertical stereotyped behaviours of rats in the Open Field situation are functions of brain noradrenergic and dopaminergic systems, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421459
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    On the mechanism of potentiation of amphetamine induced stereotype behaviour by imipramine (1972)
    Springer
    Psychopharmacology 27 (1972), S. 367-372 
    Details
    ISSN: 1432-2072
    Keywords: Open Field ; Amphetamine ; Imipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were performed to study the individual and combined effects of amphetamine and imipramine in rats with lowered brain catecholamines or 5-HT levels. The stereotyped behaviour was studied employing the “Open Field” test apparatus. When the brain catecholamine level was lowered by α-methyl tyrosine, amphetamine failed to induce complex stereotyped behaviour, while disulfiram pretreatment did not significantly alter the complex stereotyped behaviour due to amphetamine. However, pretreatment with either α-methyltyrosine or p-chlorophenylalanine modified the effects of imipramine. Imipramine augmented the amphetamine induced stereotype behaviour. Pretreatment with α-methyl tyrosine, p-chlorophenylalanine or disulfiram altered the behavioural effects due to the interaction of imipramine and amphetamine. These findings suggest that catecholamines, particularly brain dopamine, play a greater role in the stereotype behaviour due to amphetamine and its augmentation by imipramine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429390
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...