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  • 1
    Digitale Medien
    Digitale Medien
    Some 3,4,5-Trimethoxy-Substituted Benzamides1 (1965)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 8 (1965), S. 139-140 
    Details
    ISSN: 1520-4804
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jm00325a037
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacological Research in India (1974)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 14 (1974), S. 115-126 
    Details
    ISSN: 0362-1642
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.pa.14.040174.000555
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  • 3
    Digitale Medien
    Digitale Medien
    Separation of the Hypnotic Potentiating Principles from the Essential Oil of Acorus calamus L. of Indian Origin by Liquid–Gas Chromatography (1960)
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 466-467 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] It is the purpose of this communication to describe the isolation and identification of the active principle or principles responsible for the above-mentioned pharmacological activity from the essential oil of Acorus calamus L. of Indian origin. In our investigations the volatile oil distilled ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/185466a0
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  • 4
    Digitale Medien
    Digitale Medien
    An evaluation of apomorphine action on dopaminergic receptors (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1441-1443 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evaluation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO holdtrans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydronaphthalene) incorporatestrans-transoid conformation and primarily acts on post-synaptic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01923234
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  • 5
    Digitale Medien
    Digitale Medien
    Pharmacodynamical Effects of Asarone and β-Asarone (1961)
    [s.l.] : Nature Publishing Group
    Nature 192 (1961), S. 1299-1300 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The prolongation of hypnotic activity of (i) pento-barbitone, (ii) hexobarbitone, and (iii) ethanol was investigated in white mice. Asarone and p-asarone were given in different groups of animals intraperi-toneally in doses of 50 mgm./kgm., followed 15 min. later by one of the anaesthetic agents ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/1921299b0
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  • 6
    Digitale Medien
    Digitale Medien
    Modification of the effect of some central stimulants in mice pretreated with α-methyl-l-tyrosine (1967)
    Springer
    Psychopharmacology 10 (1967), S. 437-444 
    Details
    ISSN: 1432-2072
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In mice treated with α-methyltyrosine (AMT) so as to deplete the brain norepinephrine by 65 percent of the normal, the central stimulant effects of d-amphetamine, morphine, mescaline and cocaine were significantly reduced. The effects were evaluated by observing the spontaneous motor activity, the degree of eye closure and rectal temperature of mice. The hypermotility and hyperthermia caused by lysergic acid diethylamide remained unaffected by AMT treatment. Desmethylimipramine failed to antagonize the sedation produced by repeated doses of AMT which lowered brain norepinephrine by 95 percent. These results showed that except that of lysergic acid diethylamide, the central stimulant effects of other drugs and the antidepressant effect of desmethylimipramine were mediated through norepinephrine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00403985
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  • 7
    Digitale Medien
    Digitale Medien
    Modification of the effects of antipsychotic agents on the “Open Field” performance of rats by treatment with α-methyl tyrosine or p-chlorophenylalanine (1970)
    Springer
    Psychopharmacology 17 (1970), S. 361-366 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Open Field
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Experiments were performed to study the effect on “Open Field” behaviour of subthreshold doses of reserpine and chlorpromazine in rats with lowered brain catecholamine or 5-hydroxytryptamine levels. The doses of α-methyltyrosine which are known to lower brain catecholamine contents by 65% remarkably enhanced the effects of antipsychotic agents on ambulation and rearing responses. These effects could be partially antagonized by simultaneous administration of L-DOPA. The lowering of 5-hydroxytryptamine to the extent of 90% by p-chlorophenylalanine failed to modify the effects of these antipsychotic agents. The findings suggest that the brain catecholamines levels play a greater role in the mechanism of antipsychotic agents as compared to 5-hydroxytryptamine levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00403807
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  • 8
    Digitale Medien
    Digitale Medien
    On the mechanism of potentiation of amphetamine induced stereotype behaviour by imipramine (1972)
    Springer
    Psychopharmacology 27 (1972), S. 367-372 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Open Field ; Amphetamine ; Imipramine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Experiments were performed to study the individual and combined effects of amphetamine and imipramine in rats with lowered brain catecholamines or 5-HT levels. The stereotyped behaviour was studied employing the “Open Field” test apparatus. When the brain catecholamine level was lowered by α-methyl tyrosine, amphetamine failed to induce complex stereotyped behaviour, while disulfiram pretreatment did not significantly alter the complex stereotyped behaviour due to amphetamine. However, pretreatment with either α-methyltyrosine or p-chlorophenylalanine modified the effects of imipramine. Imipramine augmented the amphetamine induced stereotype behaviour. Pretreatment with α-methyl tyrosine, p-chlorophenylalanine or disulfiram altered the behavioural effects due to the interaction of imipramine and amphetamine. These findings suggest that catecholamines, particularly brain dopamine, play a greater role in the stereotype behaviour due to amphetamine and its augmentation by imipramine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00429390
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  • 9
    Digitale Medien
    Digitale Medien
    A comparative study of d- and l-amphetamine on the open field performance of rats (1974)
    Springer
    Psychopharmacology 39 (1974), S. 67-70 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Horizontal Stereotypy ; Vertical Stereotypy ; d- and l-Amphetamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Behavioural effects in the Open Field test following the administration of d- and l-amphetamine were compared in rats. A significant difference was found between the effects of the two isomers on horizontal activity, d-amphetamine alone causing horizontal stereotypy. In both cases dose-response relations were curvilinear. On the other hand, although both isomers produced vertical stereotypy, the dose-response relations were generally monotonic increasing with no signifiacnt differences between isomers. These differential effects on behaviour have been explained on the basis of stereospecificity of adrenergic neurons for amphetamine. The results of the study are consistent with earlier hypotheses that the horizontal and vertical stereotyped behaviours of rats in the Open Field situation are functions of brain noradrenergic and dopaminergic systems, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00421459
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  • 10
    Digitale Medien
    Digitale Medien
    Effects of antidepressant agents on open field behaviour in rats (1973)
    Springer
    Psychopharmacology 33 (1973), S. 333-338 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Stereotyped Behaviour ; Tricyclic Compounds ; MAOIs
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Influence of acute and chronic administration of two types of antidepressant drugs i.e. tricyclic compounds and monoamine oxidase inhibitors (MAOIs), on the Open Field behaviour in rats was examined. Two types of stereotyped behaviour were observed in the open field test namely simple stereotypy (ambulation) and complex stereotypy (rearing). Chronic administration of MAOIs primarily caused an increase in the simple stereotyped behaviour while tricyclic compounds on repeated administration selectively increased complex stereotyped behaviour. The Open Field behaviour of rats due to MAOIs is comparable to hallucinogens while the pattern seen with tricyclic agent differs from MAOIs and other central nervous system stimulant drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00437510
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