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  • 1
    Electronic Resource
    Electronic Resource
    Separation of the Hypnotic Potentiating Principles from the Essential Oil of Acorus calamus L. of Indian Origin by Liquid–Gas Chromatography (1960)
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 466-467 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It is the purpose of this communication to describe the isolation and identification of the active principle or principles responsible for the above-mentioned pharmacological activity from the essential oil of Acorus calamus L. of Indian origin. In our investigations the volatile oil distilled ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/185466a0
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacodynamical Effects of Asarone and β-Asarone (1961)
    [s.l.] : Nature Publishing Group
    Nature 192 (1961), S. 1299-1300 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The prolongation of hypnotic activity of (i) pento-barbitone, (ii) hexobarbitone, and (iii) ethanol was investigated in white mice. Asarone and p-asarone were given in different groups of animals intraperi-toneally in doses of 50 mgm./kgm., followed 15 min. later by one of the anaesthetic agents ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1921299b0
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacological Research in India (1974)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 14 (1974), S. 115-126 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.14.040174.000555
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  • 4
    Electronic Resource
    Electronic Resource
    Some 3,4,5-Trimethoxy-Substituted Benzamides1 (1965)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 8 (1965), S. 139-140 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00325a037
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  • 5
    Electronic Resource
    Electronic Resource
    Neurochemical effects of danitracen (WA-355): Mechanism of action (1982)
    Springer
    Journal of neural transmission 53 (1982), S. 217-221 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Danitracen lowered serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. The drug did not appear to affect the concentration of 5-HIAA except in the cerebellum where there was a considerable depletion. Danitracen pretreatment led to a lowering in the 5-HT levels in the various parts of the brain without influencing 5-HIAA levels in the whole brain and decreased NE levels in apomorphine and amphetamine-treated rats. The findings indicate that the mechanism of action of danitracen also involves noradrenergic neurons along with a possible increase in the metabolism of 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243413
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of some psychopharmacological agents on heat stress-induced changes in the glutathione levels of brain and blood in rats (1968)
    Springer
    Psychopharmacology 12 (1968), S. 170-175 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The effect of heat stress on the glutathione content of brain and blood in rats were studied. Observations were also made on the modification of these effects by mesacline, LSD-25, trimeglamide, meprobamate and chlorpromazine. 2. Mescaline and LSD-25 produced a significant reduction in the glutathione levels and pretreatment with these drugs only aggravated the stress-induced reduction in the glutathione levels of brain and blood. 3. Trimeglamide and meprobamate did not produce any significant change in the glutathione levels when administered alone; these drugs helped to minimize the stress-induced reduction in these levels. 4. Chlorpromazine when administered alone produced a reduction in blood glutathione level and failed to prevent the stress-induced fall in the glutathione levels of brain and blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401547
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of LSD on open field performance in rats (1969)
    Springer
    Psychopharmacology 15 (1969), S. 333-340 
    Details
    ISSN: 1432-2072
    Keywords: LSD ; Open Field Test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary LSD has been reported to have variable actions on locomotor and exploratory activity in rats. In the present study LSD in doses ranging from 2 to 500 μg/kg induced varying effects on different components of Open Field behaviour. The “ambulation score” showed a linear increase with increasing log doses while the highest dose caused a steep rise. The “rearing” and “preening scores” exhibited an inverted U type dose-response relationship, the inversion of the curve occuring with doses higher than 8 μg/kg. It is suggested that LSD in normal doses increases all stereotyped activity whereas with higher doses only simple stereotyped activity is increased. Simple horizontal stereotyped activity therefore increases at the cost of vertical stereotype. Thus LSD increases stereotyped activity with increasing dose but while normal doses increase both the horizontal and the vertical type of activity, the higher doses increase only the horizontal type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401687
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  • 8
    Electronic Resource
    Electronic Resource
    On the mechanism of potentiation of amphetamine induced stereotype behaviour by imipramine (1972)
    Springer
    Psychopharmacology 27 (1972), S. 367-372 
    Details
    ISSN: 1432-2072
    Keywords: Open Field ; Amphetamine ; Imipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were performed to study the individual and combined effects of amphetamine and imipramine in rats with lowered brain catecholamines or 5-HT levels. The stereotyped behaviour was studied employing the “Open Field” test apparatus. When the brain catecholamine level was lowered by α-methyl tyrosine, amphetamine failed to induce complex stereotyped behaviour, while disulfiram pretreatment did not significantly alter the complex stereotyped behaviour due to amphetamine. However, pretreatment with either α-methyltyrosine or p-chlorophenylalanine modified the effects of imipramine. Imipramine augmented the amphetamine induced stereotype behaviour. Pretreatment with α-methyl tyrosine, p-chlorophenylalanine or disulfiram altered the behavioural effects due to the interaction of imipramine and amphetamine. These findings suggest that catecholamines, particularly brain dopamine, play a greater role in the stereotype behaviour due to amphetamine and its augmentation by imipramine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429390
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  • 9
    Electronic Resource
    Electronic Resource
    A comparative study of d- and l-amphetamine on the open field performance of rats (1974)
    Springer
    Psychopharmacology 39 (1974), S. 67-70 
    Details
    ISSN: 1432-2072
    Keywords: Horizontal Stereotypy ; Vertical Stereotypy ; d- and l-Amphetamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Behavioural effects in the Open Field test following the administration of d- and l-amphetamine were compared in rats. A significant difference was found between the effects of the two isomers on horizontal activity, d-amphetamine alone causing horizontal stereotypy. In both cases dose-response relations were curvilinear. On the other hand, although both isomers produced vertical stereotypy, the dose-response relations were generally monotonic increasing with no signifiacnt differences between isomers. These differential effects on behaviour have been explained on the basis of stereospecificity of adrenergic neurons for amphetamine. The results of the study are consistent with earlier hypotheses that the horizontal and vertical stereotyped behaviours of rats in the Open Field situation are functions of brain noradrenergic and dopaminergic systems, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421459
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  • 10
    Electronic Resource
    Electronic Resource
    Modification of the effect of some central stimulants in mice pretreated with α-methyl-l-tyrosine (1967)
    Springer
    Psychopharmacology 10 (1967), S. 437-444 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In mice treated with α-methyltyrosine (AMT) so as to deplete the brain norepinephrine by 65 percent of the normal, the central stimulant effects of d-amphetamine, morphine, mescaline and cocaine were significantly reduced. The effects were evaluated by observing the spontaneous motor activity, the degree of eye closure and rectal temperature of mice. The hypermotility and hyperthermia caused by lysergic acid diethylamide remained unaffected by AMT treatment. Desmethylimipramine failed to antagonize the sedation produced by repeated doses of AMT which lowered brain norepinephrine by 95 percent. These results showed that except that of lysergic acid diethylamide, the central stimulant effects of other drugs and the antidepressant effect of desmethylimipramine were mediated through norepinephrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403985
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