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  • Digitale Medien  (13)
  • 1
    Digitale Medien
    Digitale Medien
    Some 3,4,5-Trimethoxy-Substituted Benzamides1 (1965)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 8 (1965), S. 139-140 
    Details
    ISSN: 1520-4804
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jm00325a037
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacological Research in India (1974)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 14 (1974), S. 115-126 
    Details
    ISSN: 0362-1642
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.pa.14.040174.000555
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  • 3
    Digitale Medien
    Digitale Medien
    Separation of the Hypnotic Potentiating Principles from the Essential Oil of Acorus calamus L. of Indian Origin by Liquid–Gas Chromatography (1960)
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 466-467 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] It is the purpose of this communication to describe the isolation and identification of the active principle or principles responsible for the above-mentioned pharmacological activity from the essential oil of Acorus calamus L. of Indian origin. In our investigations the volatile oil distilled ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/185466a0
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  • 4
    Digitale Medien
    Digitale Medien
    Pharmacodynamical Effects of Asarone and β-Asarone (1961)
    [s.l.] : Nature Publishing Group
    Nature 192 (1961), S. 1299-1300 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The prolongation of hypnotic activity of (i) pento-barbitone, (ii) hexobarbitone, and (iii) ethanol was investigated in white mice. Asarone and p-asarone were given in different groups of animals intraperi-toneally in doses of 50 mgm./kgm., followed 15 min. later by one of the anaesthetic agents ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/1921299b0
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  • 5
    Digitale Medien
    Digitale Medien
    Neurochemical effects of danitracen (WA-355): Mechanism of action (1982)
    Springer
    Journal of neural transmission 53 (1982), S. 217-221 
    Details
    ISSN: 1435-1463
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Danitracen lowered serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. The drug did not appear to affect the concentration of 5-HIAA except in the cerebellum where there was a considerable depletion. Danitracen pretreatment led to a lowering in the 5-HT levels in the various parts of the brain without influencing 5-HIAA levels in the whole brain and decreased NE levels in apomorphine and amphetamine-treated rats. The findings indicate that the mechanism of action of danitracen also involves noradrenergic neurons along with a possible increase in the metabolism of 5-HT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01243413
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  • 6
    Digitale Medien
    Digitale Medien
    An evaluation of apomorphine action on dopaminergic receptors (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1441-1443 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evaluation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO holdtrans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydronaphthalene) incorporatestrans-transoid conformation and primarily acts on post-synaptic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01923234
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  • 7
    Digitale Medien
    Digitale Medien
    The effect of some psychopharmacological agents on heat stress-induced changes in the glutathione levels of brain and blood in rats (1968)
    Springer
    Psychopharmacology 12 (1968), S. 170-175 
    Details
    ISSN: 1432-2072
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. The effect of heat stress on the glutathione content of brain and blood in rats were studied. Observations were also made on the modification of these effects by mesacline, LSD-25, trimeglamide, meprobamate and chlorpromazine. 2. Mescaline and LSD-25 produced a significant reduction in the glutathione levels and pretreatment with these drugs only aggravated the stress-induced reduction in the glutathione levels of brain and blood. 3. Trimeglamide and meprobamate did not produce any significant change in the glutathione levels when administered alone; these drugs helped to minimize the stress-induced reduction in these levels. 4. Chlorpromazine when administered alone produced a reduction in blood glutathione level and failed to prevent the stress-induced fall in the glutathione levels of brain and blood.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00401547
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  • 8
    Digitale Medien
    Digitale Medien
    Effects of LSD on open field performance in rats (1969)
    Springer
    Psychopharmacology 15 (1969), S. 333-340 
    Details
    ISSN: 1432-2072
    Schlagwort(e): LSD ; Open Field Test
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary LSD has been reported to have variable actions on locomotor and exploratory activity in rats. In the present study LSD in doses ranging from 2 to 500 μg/kg induced varying effects on different components of Open Field behaviour. The “ambulation score” showed a linear increase with increasing log doses while the highest dose caused a steep rise. The “rearing” and “preening scores” exhibited an inverted U type dose-response relationship, the inversion of the curve occuring with doses higher than 8 μg/kg. It is suggested that LSD in normal doses increases all stereotyped activity whereas with higher doses only simple stereotyped activity is increased. Simple horizontal stereotyped activity therefore increases at the cost of vertical stereotype. Thus LSD increases stereotyped activity with increasing dose but while normal doses increase both the horizontal and the vertical type of activity, the higher doses increase only the horizontal type.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00401687
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  • 9
    Digitale Medien
    Digitale Medien
    Modification of the effects of antipsychotic agents on the “Open Field” performance of rats by treatment with α-methyl tyrosine or p-chlorophenylalanine (1970)
    Springer
    Psychopharmacology 17 (1970), S. 361-366 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Open Field
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Experiments were performed to study the effect on “Open Field” behaviour of subthreshold doses of reserpine and chlorpromazine in rats with lowered brain catecholamine or 5-hydroxytryptamine levels. The doses of α-methyltyrosine which are known to lower brain catecholamine contents by 65% remarkably enhanced the effects of antipsychotic agents on ambulation and rearing responses. These effects could be partially antagonized by simultaneous administration of L-DOPA. The lowering of 5-hydroxytryptamine to the extent of 90% by p-chlorophenylalanine failed to modify the effects of these antipsychotic agents. The findings suggest that the brain catecholamines levels play a greater role in the mechanism of antipsychotic agents as compared to 5-hydroxytryptamine levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00403807
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  • 10
    Digitale Medien
    Digitale Medien
    Effects of antidepressant agents on open field behaviour in rats (1973)
    Springer
    Psychopharmacology 33 (1973), S. 333-338 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Stereotyped Behaviour ; Tricyclic Compounds ; MAOIs
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Influence of acute and chronic administration of two types of antidepressant drugs i.e. tricyclic compounds and monoamine oxidase inhibitors (MAOIs), on the Open Field behaviour in rats was examined. Two types of stereotyped behaviour were observed in the open field test namely simple stereotypy (ambulation) and complex stereotypy (rearing). Chronic administration of MAOIs primarily caused an increase in the simple stereotyped behaviour while tricyclic compounds on repeated administration selectively increased complex stereotyped behaviour. The Open Field behaviour of rats due to MAOIs is comparable to hallucinogens while the pattern seen with tricyclic agent differs from MAOIs and other central nervous system stimulant drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00437510
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