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  • 11
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 4064-4064 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: It is well known that the effective anisotropy field change Δ(Hk−4πMs) in as-He+/Ne+-implanted garnet films reaches a maximum value (2500 Oe) and then decreases with increasing the ion dose. It has been also reported that the Δ(Hk−4πMs) is recovered to the maximum value by annealing in the heavily implanted films. We have found an anomalous increase in Δ(Hk−4πMs) for the films which are heavily implanted with He+ or Ne+ and subsequently annealed at high temperature (350–600 °C). With annealing, Δ(Hk−4πMs) increases with annealing time and reaches a maximum value (5000 Oe for He+ implantation). It should be noticed that this maximum value is 2500 Oe larger than that in as-implanted films. This anomalous increase has been observed only for the films whose initial strain is more than about 1.5%. This effect has not been observed in heavily H+2 implanted films. This difference may be related to the type of damage induced by He+/Ne+ implantation and H+2 implantation. Using the above-mentioned effect, 4-μm-period ion-implanted propagation tracks have been fabricated and tested . The ion implantation condition was 50 keV/1×1014 Ne cm−2+200 keV/4.5×1014 Ne cm−2. Δ(Hk−4πMs) in the as-implanted film was 1900 Oe. After 560 °C annealing, it increased to 3700 Oe. For the 4-μm-period contiguous disk propagation tracks, 10% bias field margin has been obtained.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 4080-4080 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Hybrid bubble memory devices using ion-implanted and Permalloy bubble propagation tracks have been proposed and developed. In this paper, the reduction of the cell size from 4 to 3 μm will be discussed. In the hybrid devices, the minor loops are composed of ion-implanted tracks and the functions are composed of Permalloy tracks. To reduce the cell size, therefore, both of the tracks should be improved. For the 3-μm-period ion-implanted tracks, the bubble diameter is reduced from 1 to 0.8 μm. According to the reduction of a bubble diameter, magnetostrictive anisotropy Δλ=λ100−λ111 is increased from 5 to 8×10−6 because the Sm content is increased to increase the anisotropy field Hk. The large Δλ affects the characteristics of inside and outside turns in the ion-implanted tracks. To get a good margin for the turns, the anisotropy field change induced by ion implantation ΔHk should be larger than in 4-μm-period tracks. There is a new problem in 3-μm-period hybrid devices. In the hybrid devices, there is no deep ion implantation in the Permalloy track region, while there is a deep ion implantation in the ion-implanted track region. The effective bubble height is, therefore, different in the ion-implanted and Permalloy track region, and the bias field region where bubbles exist stable is different. In the typical 3-μm-period devices, the bias field region of the ion-implanted tracks is 20–30 Oe lower than that of the Permalloy tracks. The operating bias field adjustment (OBA) is needed. We have checked some OBA methods and found that the thinning of the garnet film in the Permalloy track region is a good method. Thinning the garnet film partially, the operating bias field can be adjusted easily and there is no harmful effect.
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: This work was undertaken to determine the growth parameters of Lockhart’s equation for finding which component was predominantly contributing to the cell expansion rates of plants subjected to environmental stresses under tissue-culture conditions. Embryos isolated from soybean (Glycine max [L.] Merr.) and kidney bean (Phaseolus vulgaris L.) seeds were grown under tissue-culture conditions. The water potential of culture media ranged from − 0·02 to − 0·94 MPa so that nutrient deficiency and salt stress conditions could be applied. Additionally, the temperature of culture conditions was set from 10 to 40 °C to apply low-temperature and high-temperature stresses on plants grown at the optimum concentration of culture medium. Cell expansion could be inhibited completely by adding 2,4-dichlorophenoxyacetic acid and benzylaminopurine to culture media to form callus tissue. The sizes of the water potential gradient between the water source and elongating cells correlated with the speed of growth rates under nutrient deficiency, salt stress, growth retardation induced by plant hormones, low-temperature and high-temperature conditions in the present study, indicating that cell expansion rates were mainly associated with how much water could be absorbed by elongating cells regardless of the kinds of environmental stress conditions applied.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The dental plaque of 96 healthy donors was screened for the production of such antibacterial substances as mutalipocin and bacteriocin and 192 strains of mutans streptococci isolated: 28 produced mutalipocin and 22 produced bacteriocin. Mutalipocin produced by these 28 S. mutans strains possessed similar biochemical and biological characteristics of well-characterized mutalipocin-producing strain S. mutans 32K (serotype c). When equal amounts of S. mutans 32K and S. sobrinus 6715 (g) were cultured together, cells of S. sobrinus 6715 were completely killed in 18 h. In addition, S. mutans 32K inhibited in vitro plaque formation by S. sobrinus 6715, and S. mutans 32K also eliminated in vitro plaque preformed by S. sobrinus 6715. In rat experiments, S. mutans 32K could preemptively colonize in plaque preformed by S. sobrinus 6715. On the other hand, S. sobrinus 6715 could not colonize in plaque preformed by S. mutans 32K. The results indicate that S. mutans serotype c which produces antibacterial substances is able to invade denatl plaque and replace the other mutans streptococci. This investigation offers one of the possible explanation why S. mutans serotype c is a predominant species among mutans streptococci in human plaque.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 24 (1989), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sonic extract (SE) from periodontopathic bacteria were studied for their effects on the immune response and adjuvanticity. The preparations of SE from A. actinomycetemcomitans, B. intermedius and B. gingivalis were found to have strong immunomodulating activity against the antigen itself and also sheep erythrocytes (SRBC) in in vivo experiments using C3H/HeN mice. All the SE enhanced the immune response to antigen and SRBC at low concentration. A strong immuno suppressive effect, however, was found at high concentrations of A. actinomycetemcomitans and B. intermedius but not of B. gingivalis. Moreover, these immunosuppressive effects were enhanced by the 3-day-prior injection to SRBC even at low concentrations, including that of B. gingivalis. The suppressive effect of SE from A. actinomycetemcomitans was dependent on the protein fraction in the SE tested, because suppressed anti-SRBC immune response was restored by pronase treatment or heating. Failure to recover immune response, found in a similar experiment using Bacteroides intermedius, indicated that its suppressive effect was due to a heat-stable and pronase-resistant substance. These findings, along with the data presented in this paper, support the hypothesis that patients who harbor these bacteria could suffer systemic immune suppression not only from the initial periodontopathic bacteria but also from secondary infecting bacteria. These suppressive effects may also enhance the pathogenicity of other opportunistic organisms in the gingival crevice.
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 0020-1693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: We cultured Dermatophagoides farinae (Df), one of the most common mites in house dust and the most important allergen among natural allergens. With this material, we attempted to produce an animal model of the atopic eczema/dermatitis syndrome (AEDS).Methods: We cultured Df mites in high density and prepared a crude extract of Df (DfE) together with the culture medium. We applied the extract to the back skin of NC/Nga and BALB/c mice three times per week for 8 weeks.Results: In the NC/Nga group, dryness or scaling appeared on the skin, and scratching behavior increased at the second week in the DfE-treated group. Skin erosion and hemorrhage occurred at the fourth week. The epidermis thickened and deepened into the upper dermis, in which mast cells were highly accumulated, corresponding with the skin lesion of AEDS patients. Specific IgE and IgG to DfE and total IgE were elevated in the sera. Mice treated with an extract of mite culture medium did not develop skin lesions. In the BALB/c group, mice developed specific IgE and IgG to DfE, however, no typical skin lesions appeared. Mast cells in the upper dermis did not increase.Conclusions: Repeated painting of Dermatophagoides extract produced IgE-associated AEDS-like lesions on the skin of NC mice.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 53 (1998), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Recent studies have revealed that interleukin (IL)-13, as well as IL-4, causes de novo surface expression of vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells of the umbilical vein and accelerates selective eosinophil migration. However, its role in allergic rhinitis remains to be clarified. Of particular interest is whether IL-13 upregulates VCAM-1 expression in human mucosal microvascular endothelial cells (HMMECs), to which eosinophils adhere in nasal mucosa. Methods To understand the potential role of IL-13 in eosinophilic inflammation in nasal mucosa, we examined the effects of IL-13 on the adhesiveness between HMMECs and eosinophils. Results IL-13 increased VCAM-1 expression in HMMECs, the adhesiveness of endothelial cells to eosinophils, and the transendothelial migration. On the other hand, IL-13 decreased the adhesiveness of eosinophils to HMMECs, and, as a result, accelerated eosinophil infiltration. Those effects are more potent than was those of IL-4. In addition, we also report that the amount of IL-13 in nasal mucosa was higher than that of IL-4. Conclusions These results strongly indicate that IL-13. as well as IL-4, may be important in eosinophilic inflammation in the nasal mucosa.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of OKY-046, a specific thromboxane (TX) synthetase inhibitor, on blood pressure, urinary excretion of TX and its release from blood platelets and renal papilla, and pathological change of glomeruli were evaluated in Dahl salt-sensitive rats.2. Average daily intakes of OKY-046-treated rats were 0.93 mg/kg (low dose), 9.8mg/kg (moderate dose), and 88 mg/kg (high dose).3. Systolic blood pressure tended to decrease by 6.3, 11.4, and 10.9% in three OKY-treated groups.4. OKY-046 suppressed the release of TX from platelets in a dose-dependent fashion. Both TX in urine and released from renal papilla decreased in OKY-treated groups with moderate and high dose. OKY-046 resulted no change in urinary excretion or release from renal papilla of prostaglandin E2 or 6-keto-prostaglandin F1α.5. Glomerular sclerosis score decreased significantly in both groups treated with moderate and high doses of OKY-046.6. An inhibition of renal TX synthesis by TX synthetase inhibitor has a protective effect on the development of hypertensive renal damage with minor antihypertensive effect in Dahl salt-sensitive rats.
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 〈list xml:id="l1" style="custom"〉1To clarify whether acute changes in the properties of baroreflexes can occur in man, we evaluated the time course of baroreflex control of heart rate and cardiopulmonary baroreflex control of forearm vascular resistance (FVR) over 240 min after intravenous administration of propranolol (0.2 mg/kg) in 13 healthy young men.2Systolic and diastolic blood pressure remained unchanged after propranolol. Propranolol significantly decreased cardiac index and heart rate, and significantly increased total peripheral resistance. These effects remained unchanged for 240 min after propranolol.3Baroreflex control of heart rate was significantly augmented immediately after, and at 30, 60 min after propranolol, but partly reverted to the initial level afterwards. Cardiopulmonary baroreflex control of FVR was reduced immediately after, and at 30, 60 min after propranolol, but partly reverted to the initial level afterwards. Pressor responses to phenylephrine was reduced immediately after propranolol, but no significant differences were observed after 30 min.4These results suggest that acute changes in the properties of baroreflexes occur in man after propranolol.
    Type of Medium: Electronic Resource
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