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  • 1
    Electronic Resource
    Electronic Resource
    Assessment of the alcohol withdrawal syndrome—validity and reliability of the translated and modified Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-A) (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction 89 (1994), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The alcohol withdrawal syndrome is a common phenomenon in psychiatric hospital care. Not only treatment strategies, but also the evaluation of the syndrome, are discussed controversially. The most widely used instrument is the Clinical Institute Withdrawal Assessment-Alcohol (CIWA-A) and the succeeding CIWA-Ar. We modified the CIWA-A and translated it into German. Validity and reliability of the modified and translated scale were analysed by several psychological tests as well as different somatic measures in 31 patients. The German version appears to be a valid and reliable instrument for the assessment of alcohol withdrawal syndrome useful for clinical routine as well as treatment trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1360-0443.1994.tb03307.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clozapine plasma levels determined by high-performance liquid chromatography with ultraviolet detection
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 428 (1988), S. 160-166 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0378-4347(00)83902-X
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  • 3
    Electronic Resource
    Electronic Resource
    Eine neuc Umlagerung an einem Metathebainon-Derivat mit Cyclohexa-2,5-dienon-Struktur (1969)
    Springer
    Monatshefte für Chemie 100 (1969), S. 163-174 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Abstract 4-O-Methyl-7.8-dehydrometathebainonemethine (1) in alkaline solution rearranges to the naphthalene derivative3, which eliminates formiate to give7. The occurrence of3 was confirmed by isolation of13a after reduction with NaBH4. The hydroxy compounds8a and13a, obtained by reduction, eliminate methanol and cyclize to the 2.3-dihydronaphtho[1.8-bc]pyrans9 and14.
    Notes: Zusammenfassung 4-O-Methyl-7,8-dehydro-metathebainon-methin (1) geht in alkalischer Lösung in das Naphthalin-Derivat3 über, das unter Abspaltung von Formiat7 liefert. Das Auftreten von3 kann durch Isolierung von13a nach Reduktion mit NaBH4 nachgewiesen werden. Die aus3 und7 durch Reduktion erhaltenen Alkohole8a und13a werden in saurer Lösung unter Methanol-Abspaltung zu den 2,3-Dihydro-naphtho[1,8-bc]pyranen9 und14 cyclisiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00938253
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  • 4
    Electronic Resource
    Electronic Resource
    7-Hydroxy-neopinon-dimethylacetal (1971)
    Springer
    Monatshefte für Chemie 102 (1971), S. 558-568 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Durch Schütteln einer Lösung von 14-Brom-codeinon-dimethylacetal (1 b) in methanol. NaOH mit einem besonders vorbehandelten Hydrierungskatalysator an der Luft entsteht das bisher noch nicht beschriebene (7R)-7-Hydroxy-neopinon-dimethylacetal (6) (Ausb. 75%). Die Nebenprodukte7, 8, 9, 10a und10 b wurden durch präp.DC getrennt und in kristallisierter Form gewonnen. Ihre Struktur sowie die Konfiguration am C-7 wurde vor allem NMR-spektroskopisch ermittelt.
    Notes: Abstract The synthesis of (7R)-7-Hydroxy-neopinone dimethyl acetal (6) has been performed by shaking on air a solution of 14-bromo-codeinone-dimethyl acetal (1 b) in alcoholic NaOH in the presence of an especially prepared hydrogenation catalyst in 75% yield. The by-products7, 8, 9, 10a, and10b were isolated by preparative thin layer chromatography. The structures and the configuration on C-7 were established on the basis of NMR-spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00909353
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  • 5
    Electronic Resource
    Electronic Resource
    Ein neuer Weg zum (−)-Sinomeninon (1971)
    Springer
    Monatshefte für Chemie 102 (1971), S. 643-647 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die beiden epimeren 7-Hydroxy-neopinon-dimethylacetale1 und2 gehen bereits unter den milden Bedingungen der Acetalhydrolyse in Δ(4) über. In Analogie zu dieser Reaktion liefert 7-Hydroxy-dihydro-codeinon-dimethylacetal (6) bei der Behandlung mit HCl den Sinomeninon-Antipoden (5), in 85proz. Ausbeute.
    Notes: Abstract The epimeric 7-hydroxy-neopinone-dimethylacetals1 and2, under the considerate conditions of acetal hydrolysis, are converted to 8(14)-7-oxo-thebainone (4). Similar treatment of 7-hydroxy-dihydro-codeinone-dimethylacetal (6) leads to (−)-sinomeninone (5), yield 85%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01167242
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  • 6
    Electronic Resource
    Electronic Resource
    Die Methanolyseprodukte von 14-Brom-codeinon-dimethylacetal: (14S)-14-Methoxy-codeinon (1972)
    Springer
    Monatshefte für Chemie 103 (1972), S. 1066-1077 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Beim Erhitzen von 14-Brom-codeinon-dimethylacetal (1) in absol. Methanol mit einer äquivalenten Menge Na2CO3 entstehen die drei isomeren Methoxycodeinon-acetale3, 4 und5 sowie die beiden Indolino-codeinonderivate6 und7. Die Strukturen und Konfigurationen der Verbindungen3–6 werden auf Grund der NMR- und IR-Spektren sowie durch Umwandlung in bekannte Verbindungen bewiesen.
    Notes: Abstract 14-Bromocodeinone dimethyl acetal (1) reacts in methanol containing sodium carbonate (0.5 moles) to give the three isomeric methoxycodeinone acetals3, 4, and5 besides the indolino-codeinones6 and7. The structures and configurations of3–6 were established on the basis of NMR- and IR-spectroscopy and by conversion to known compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00905182
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  • 7
    Electronic Resource
    Electronic Resource
    Struktur- und Konfigurationsbeweis für das Diketon aus 14-Bromcodeinon (1970)
    Springer
    Monatshefte für Chemie 101 (1970), S. 1215-1222 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Abstract The diketo compounds formed in the hydrolysis of 14-bromocodeinone (1) and 7-bromoneopinone methoperchlorate, resp., have been shown to possess structure and configuration of Δ8(14)-7-oxothebainone (5) and its methoperchlorate, resp. The quinoxaline derivative7, obtained by condensation of5 with o-phenylenediamine, yields two dihydro compounds (8 and10) diastereomeric at C-6a.8 has been found to be the enantiomer of the condensation product obtained from sinomeninone (6) and o-phenylenediamine.
    Notes: Zusammenfassung Es wird nachgewiesen, daß den aus 14-Brom-codeinon (1)* bzw. 7-Brom-neopinon-methoperchlorat durch einfache Hydrolyse entstehenden Diketoverbindungen die Struktur und Konfiguration von Δ8(14)-7-Oxo-thebainon (5) bzw. des entsprechenden Methoperchlorats zukommt. Das durch Kondensation von5 mit o-Phenylendiamin entstehende Chinoxalinderivat7 gibt zwei am C-6a diastereomere Dihydroverbindungen (8 und10), wobei8 das Enantiomere des Kondensationsproduktes von Sinomeninon (6) und o-Phenylendiamin darstellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00908568
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  • 8
    Electronic Resource
    Electronic Resource
    Reaktionen von (−)-Ephedrin bzw. (+)-Norpseudoephedrin und Derivaten mit N,N-Dimethylacetamid-dimethylacetal und N,N,-Dimethylformamid-dimethylacetal (1992)
    Springer
    Monatshefte für Chemie 123 (1992), S. 911-918 
    Details
    ISSN: 1434-4475
    Keywords: (−)-Ephedrine ; (+)-Norpseudoephedrine ; N,N-Dimethylacetamid-dimethylacetal ; N,N-Dimethylformamid-dimethylacetal ; Sympathomimetic effects ; Sigmatropic rearrangements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The reactivity of (−)-ephedrine (2) and (+)-norpseudoephedrine (3) towards the amidacetals1 a/b has been studied. Both2 and3 were acetylated resp. formylated at first at the amino group. Nevertheless, derivatives of2 and3 possessing a trisubstituted amino group react with1 a in a [3.3] sigmatopic rearrangement toortho substituted dimethylcarbamoylmethyl derivatives. By subsequent reduction with lithiumaluminiumhydride the aromatic compounds8,13, and18 with two aminoethyl groups are easily available. In contrast to these results1 b did not furnish any rearrangement products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811546
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  • 9
    Electronic Resource
    Electronic Resource
    Erstmalige Herstellung von N,C10-überbrückten Morphin-Derivaten 5H-10,13-Iminoethanophenanthro[4,5-bcd]furan, 1. Mitt. (1993)
    Springer
    Monatshefte für Chemie 124 (1993), S. 909-922 
    Details
    ISSN: 1434-4475
    Keywords: 7-Iodo-neopinondimethylacetal ; 5H-10,13-Iminoethanophenanthro[4,5-bcd]furan ; Hofmann-degradation of ammonium-bases ; Azepinocodeines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary In addition to recently reported results [1, 2] we present a new codeine-analogue7 with a different structural pattern in the nitrogen-region of the alkaloid. Synthesis by two different routes and some elucidating reactions are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00816414
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  • 10
    Electronic Resource
    Electronic Resource
    N,C10-Überbrückte Morphinalkaloide, 5H-10,13-Iminoethano-phenanthro[4,5-bcd]furan, 3. Mitt. (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 355-361 
    Details
    ISSN: 1434-4475
    Keywords: (5H)-10,13-Iminoethano-phenanthro[4,5-bcd]furan ; (5H) 3,6-Dimethoxy-N-methyl-14,13-iminoethano-phenanthro[4,5-bcd] (8H)-8-chloracetate ; (5H)-3,6,8-Trimethoxy-(8H)14,13-iminoethanophenaophenanthro[4,5-bcd]furan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary In continuation of our recent papers [2, 3] a successful approach to N,C-10-bridged morphine derivatives by rearrangement of the chloroacetate of the previously described indolinocodeinone dimethylacetal is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811321
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