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  • 1
    Electronic Resource
    Electronic Resource
    One-week triple therapy with omeprazole, amoxycillin and either clarithromycin or metronidazole for cure of Helicobacter pylori infection (1996)
    Oxford BSL : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: The present study was designed to evaluate the efficacy and tolerability of 1-week triple therapy regimens for Helicobacter pylori. Methods: In two consecutive series, 120 patients with proven H. pylori infection and peptic ulcer disease or functional dyspepsia were treated with either omeprazole 20 mg b.d., amoxycillin 1 g b.d. and clarithromycin 250 mg b.d. (OAC; n=60) or with omeprazole 20 mg b.d., amoxycillin 1 g b.d. and metronidazole 400 mg b.d. over 1 week (OAM; n=60). H. pylori infection was assessed by rapid urease test, culture and histology before and 4 weeks after cessation of the eradication therapy. Results: H. pylori eradication succeeded in 53 out of 60 patients by omeprazole–amoxycillin–clarithromycin (OAC) (88%; 95% CI 77–95%) and in 47 out of 60 patients by omeprazole–amoxycillin–metronidazole (OAM) (78%; 95% CI 66–88%) (P=0.22). Nine patients of each group available for follow-up reported adverse events (15.0 and 15.5%, respectively) without necessity of discontinuation of the study medications. Serious adverse events were not observed. Conclusions: Simple and convenient 1-week triple therapies consisting of omeprazole, amoxycillin and either clarithromycin or metronidazole are sufficiently effective in eradicating H. pylori infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1996.727119000.x
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  • 2
    Electronic Resource
    Electronic Resource
    High rate of post-therapeutic resistance after failure of macrolide–nitroimidazole triple therapy to cure Helicobacter pylori infection: impact of two second-line therapies in a randomized study (2002)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The optimal second-line treatment after failed Helicobacter pylori therapy has not been established.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:To ascertain whether quadruple therapy or triple therapy with omeprazole, clarithromycin and amoxicillin is the superior re-treatment after triple therapy containing a macrolide and a nitroimidazole, and to determine the impact of microbial in vitro resistance.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Patients after failed triple therapy were randomly allocated to one of two 1-week second-line treatments: omeprazole, 40 mg, clarithromycin, 500 mg, and amoxicillin, 1 g, all b.d.; or omeprazole, 20 mg b.d., bismuth subsalicylate, 600 mg q.d.s., metronidazole, 400 mg t.d.s., and tetracycline, 500 mg q.d.s. Post-therapeutic Helicobacter pylori status was assessed by 13C-urea breath test at least 4 weeks after treatment.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The study was terminated after including 84 patients. H. pylori cure rates differed significantly: omeprazole–clarithromycin–amoxicillin: intention-to-treat, 43%; per protocol, 50%; omeprazole–bismuth subsalicylate–metronidazole–tetracycline: intention-to-treat, 68%; per protocol, 69%. The frequencies of resistance after first-line therapy were: metronidazole, 90%; clarithromycin, 71%; both combined, 68%. For clarithromycin resistance, H. pylori cure with omeprazole–clarithromycin–amoxicillin was 30% vs. 83% for clarithromycin susceptibility.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Omeprazole–bismuth subsalicylate–metron- idazole–tetracycline was superior to omeprazole–clarithromycin–amoxicillin, but both therapies yielded unsatisfactory results. The high rate of post-therapeutic dual resistance has a negative impact on omepraz- ole–clarithromycin–amoxicillin, and probably also on omeprazole–bismuth subsalicylate–metronidazole–tetracycline, and limits the choice for second-line treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01173.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effective treatment after failure of omeprazole plus amoxycillin to eradicate Helicobacter pylori infection in peptic ulcer disease (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 8 (1994), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Methods: Fifty patients with relapsing or complicated Helicobacter pylori positive duodenal (n= 41) or gastric ulcer disease (n= 9) and failure of a combined treatment with omeprazole plus amoxycillin to eradicate H. pylori infection were re-treated with either oral triple therapy (bismuth subsalicylate, metronidazole, tetracycline) plus ranitidine [group I: n= 22] or high-dose omeprazole (40 mg b.d. to t.d.s.) plus amoxycillin (1 g t.d.s.) [group II: n= 28]. Results: Patients of group I and II had similar demographic and clinical characteristics. The overall proportion of eradication of H. pylori infection was 81.8% in group I and 78.6% in group II (P= N.S.) as judged from negative bacterial findings by means of an urease test, specific culture and histology after modified Giemsa stain. Ulcer healing was observed in all patients after a maximum duration of 10 weeks. Ten patients on triple therapy and only one patient on omeprazole plus amoxycillin (45.5%vs. 3.6%; P 〈 0.001) complained of side effects without necessity of discontinuation of the study medication in either group. Twenty patients (group I: n= 10: group II: n= 10) with relapsing duodenal ulcer disease and successful cure were prospectively followed for one year without any evidence of ulcer relapse or H. pylori re-infection. Conclusion: Oral triple therapy plus ranitidine or highdose omeprazole plus amoxycillin remain highly effective in eradicating H. pylori infection in patients with peptic ulcer disease and treatment failure of omeprazole/amoxycillin, but the omeprazole enhanced antibiotic monotherapy seems to be superior with regard to side effects. Thus, high-dose omeprazole/amoxycillin is recommended as the treatment of first choice in these selected patients. Triple therapy should be reserved for patients intolerant of amoxycillin
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1994.tb00295.x
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  • 4
    Electronic Resource
    Electronic Resource
    One-week low-dose triple therapy for Helicobacter pylori is sufficient for relief from symptoms and healing of duodenal ulcers (1997)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To test the hypothesis that 1-week low-dose triple therapy for H. pylori is sufficient for relief from dyspeptic symptoms and healing of duodenal ulcers. Methods: Fifty-nine out-patients with duodenal ulcers and positive rapid urease test participated in this randomized, double-blind, two-centre study. All patients were treated for 1 week with omeprazole 20 mg b.d., clarithromycin 250 mg b.d. and metronidazole 400 mg b.d. In a double-blind fashion, patients were then randomly treated for another 3 weeks with either omeprazole 20 mg once daily or an identical-looking placebo. Patients were investigated endoscopically before treatment for H. pylori, after 2 weeks and after 4 weeks. H. pylori infection was assessed by a 13C-urea breath test at the time of enrolment and 4 weeks after cessation of any study medication. Results: Fifty-two patients were included in the ‘all patients treated’ analysis of efficacy. The overall H. pylori cure rate was 96% (95% CI=87–100%), with no difference between the treatment groups. After 2 weeks duodenal ulcer healing was confirmed in 91% (95% CI=80–100%) of patients treated with omeprazole and in 76% (95% CI=60–91%) in the placebo group (P=0.14). After 4 weeks all ulcers had healed. Relief from dyspeptic symptoms and adverse events (13.8 and 16.7%) did not differ between the treatment groups. Conclusions: One-week low-dose triple therapy consisting of omeprazole, clarithromycin and metronidazole is a highly effective and well-tolerated approach to the cure of H. pylori infection in patients with a duodenal ulcer. Our data suggest that continuation of antisecretory drug therapy beyond anti-H. pylori therapy is actually excessive regarding relief from dyspeptic symptoms and healing of duodenal ulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.80252000.x
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  • 5
    Electronic Resource
    Electronic Resource
    Der Gastrointestinaltrakt als Immunorgan: Das darmassoziierte Immunsystem (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 699-709 
    Details
    ISSN: 1432-1440
    Keywords: Gastrointestinal diseases-Immunology ; Mucous membrane ; Lymphoid tissue ; Plasma cells ; IgA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The gastrointestinal mucosa separates the intraluminal gastrointestinal fluid, which contains a high number of antigens from different sources, and prevents free access of antigens to the body. Simultaneously, it allows some vital host-environment interactions. A number of unspecific factors are important in preventing antigen invasion. The specific mucosal immunity is related to secretory IgA. IgA is derived from mucosal plasma cells after antigen-induced proliferation of its precursors in Peyer's patches. These IgA-positive B-lymphoblasts migrate through the systemic circulation and then “home” to the mucosa. IgA is translocated as a dimer to the gut lumen after attachment to the secretory component (SC). Part of it is excreted into the bile via small bile ducts after portal and possibly systemic circulation and binding to SC. T cells and mast cells are also considered to show migration and homing phenomena. In addition to the gut, some other mucosa-associated lymphoid tissues, (e.g. bronchus, mammary, salivary and lacrimal glands as well as the female genital tract), can participate in homing. Little is known about the local regulatory mechanisms, which allow an immunoglobulin class specifity of immune responses. Induction of local immunity and specific systemic tolerance seems to be a characteristic immune response of the gut-associated lymphoid tissue (GALT). The knowledge of the local immune system allows a better understanding of many aspects of gastrointestinal pathology, especially in immuno-inflammatory and immunoproliferative diseases as well as in gastrointestinal immunodeficiency syndromes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725702
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  • 6
    Electronic Resource
    Electronic Resource
    Prajmaliumbitartrate-associated liver damage (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 998-1000 
    Details
    ISSN: 1432-1440
    Keywords: Prajmaliumbitartrate ; intrahepatic cholestasis ; Liver (drug effects) ; Antiarrhythmic agents (adverse effects)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven further cases with n-propyl-ajmaliumbitartrate (NPAB)-associated liver damage observed between 1976 and 1980 in two collaborating institutions are reported. The cause/effect relationship could be classified as probable in three cases and as potential in the remaining four patients. No drug rechallenge was carried out. In the clinical management, definite exclusion of biliary tract obstruction had a clear priority over histologic documentation of the degree of the transient liver damage. Follow-up data after 2 years 8 months to 5 years 9 months by personal reinvestigation of three patients and by questionnaire to family physicians and patients in the remaining four cases gave no clinical or serologic indication of persisting or relapsing liver damage. Liver biopsies were not considered to be warranted in the follow-up of these asymptomatic patients with normal liver function tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728432
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  • 7
    Electronic Resource
    Electronic Resource
    The role of testosterone in the feedback control of male FSH and LH secretion (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 237-239 
    Details
    ISSN: 1432-1440
    Keywords: FSH ; LH ; testosterone ; gonadotropin regulation ; FSH ; LH ; Testosteron ; Gonadotropinregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Intramuskuläre Injektion von 250 mg Testosteronönanthat je Woche über 21 Wochen fürhrte zu einem raschen und anhaltenden Absinken der Serum-FSH- und -LH-Spiegel bei sieben männlichen Normalpersonen, während die Serum-Testosteronspiegel um etwa einen Faktor 2 anstiegen. Diese und frühere Ergebnisse verweisen auf eine zweifache Feedback-Hemmung der FSH-Sekretion beim Mann durch Gonadensteroide sowie einen bis heute nicht näher charakterisierten tubulären Hodenfaktor.
    Notes: Summary Intramuscular administration of 250 mg testosterone oenanthate per week over a period of 21 weeks treatment rapidly and sustainedly suppressed serum LH as well as FSH levels in seven normal males, while serum testosterone rose by a factor of approximately two. These together with other data provide increasing evidence for a feedback control of FSH secretion by gonadal steroids in the male in addition to the already described but as yet undefined tubular testicular factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468813
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  • 8
    Electronic Resource
    Electronic Resource
    Acute colonic pseudo-obstruction (Ogilvie's syndrome) (1987)
    Springer
    Surgical endoscopy and other interventional techniques 1 (1987), S. 169-174 
    Details
    ISSN: 1432-2218
    Keywords: Acute colonic pseudo-obstruction ; Ogilvie's syndrome ; Colonoscopic decompression ; Cecostomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In addition to the presentation of 14 of our own patients, this study analyzes 1027 cases with acute colonic pseudo-obstruction reported in the literature from 1948 to 1987. Principal associated diseases are cardiopulmonary insufficiencies, postoperative conditions, and systemic disorders. The syndrome is related to a disturbance of colonic autonomic innervation resulting in gross dilatation of the cecum and the right hemicolon. Therapeutic measures include conservative management, colonoscopic decompression, and surgical procedures. The latter have been associated with high morbidity and mortality. Our data support a nonoperative approach to this condition, including conservative measures and colonscopic decompression as the initial therapy of choice with few complications and high efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00590926
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  • 9
    Electronic Resource
    Electronic Resource
    194. Zur Funktion des thorakalen Magens: Pyloroplastik oder nicht? (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 845-846 
    Details
    ISSN: 1435-2451
    Keywords: Intrathoracic stomach ; 24 h pH measurement ; Gastric drainage ; Intrathorakaler Magen ; 24 h pH-Metrie ; Drainageoperation des Magens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 11 Patienten mit einer distalen Resektion des Oesophagus und einer Oesophagogastrostomie in Höhe der Trachealbifurkation (n = 5) und einer transabdominalen subtotalen Oesophagektomie ohne Thoracotomie (n = 6) wurden untersucht. Es wurden keine Drainageoperationen ausgeführt. 6 Patienten hatten ein Plattenepithel-, 3 ein Adenocarcinom des Oesophagus, 2 ein Kardiacarcinom. Die Patienten wurden endoskopisch bis zu 8mal untersucht, jeder Patient hatte mindestens ein postop. CT, 4 Patienten wurden 24 h pH-metriert. 7 Patienten hatten eine Oesophagitis, 5 eine Gastritis. Obwohl die Mehrzahl der Patienten Speisereste im Magen zeigte, wurde bei keinem tumorfreien Patienten eine Magenausgangsstenose beobachtet. Eine primäre Drainageoperation des Magens halten wir daher für nicht indiziert.
    Notes: Summary Eleven patients with distal resection of the esophagus and esophagogastrostomy at the level of the tracheal bifurcation (n = 5), as well as transhiatal esophagectomy without thoracotomy (n = 6), were studied. No drainage procedures were carried out. Three patients had an adenocarcinoma and 6 squamous cell carcinoma of the esophagus. Two patients presented with carcinoma of the cardia. The patients were examined endoscopically up to 8 times. In each patient at least one postoperative CAT scan was carried out; pH was measured for 24 h in 4 patients. Seven had esophagitis and 5 had gastritis of various degrees. Although the majority of the patients had food remains in the stomach, no gastric outlet stenosis was observed. Thus a primary gastric drainage operation is not necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297978
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  • 10
    Electronic Resource
    Electronic Resource
    185. Notfallcoloskopie als Entscheidungshilfe für die Operationsindikation (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 743-743 
    Details
    ISSN: 1435-2451
    Keywords: Colonoscopy ; Acute intestinal bleeding ; Ileus ; Acute pseudo-obstruction ; Coloskopie ; Akute untere Intestinalblutung ; Ileus ; Akute Pseudoobstruktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In 5 Jahren wurden von 1565 Coloskopien 30 (1,9%) notfallmäßig durchgeführt. Bei 7 von 13 Patienten mit akuter Intestinalblutung war eine Lokalisation ohne Segmentzuordnung im Colon möglich. Bei 13 von 17 Patienten mit klinischen und radiologischen Zeichen eines Dickdarmileus ergab sich durch den endoskopischen Ausschluß eines mechanischen Hindernisses die Diagnose einer akuten Pseudoobstruktion. 12 dieser meist polymorbiden Patienten konnten durch die gleichzeitige endoskopische Dekompression risikoarm und erfolgreich therapiert werden. Bei strenger Indikationsstellung war die Notfallcoloskopie eine Hilfe sowohl für die OP-Indikaton wie für den OP-Zeitpunkt und das intraoperative Vorgehen.
    Notes: Summary In 5 years, 30 of 1565 colonoscopies (1.9%) were performed as emergency procedures. In 7 of 13 patients with acute intestinal bleeding, localization to the colon without determination of the segment was possible. In 13 of 17 patients with clinical and radiological signs of colonic ileus, the diagnosis of acute pseudo-obstruction was established endoscopically by ruling out mechanical obstruction. Of these morbidly ill patients, 12 could be safely treated by endoscopic decompression with success. With a strict indication for surgery emergency colonoscopy was a great aid to determining both the indication for and the time of operation, as well as the intra-operative procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274503
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