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  • 1
    Electronic Resource
    Electronic Resource
    Secretory Component in Immunoglobulin Deficiency: an Immunoelectron Microscopic Study of Intestinal Epithelium (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ultrastructural sites of secretory component (SC) in the intestinal epithelium of severely immunoglobulin-deficient and immunologically intact persons were compared. SC was found in the same sites in the immunoglobulin-deficient and normal epithelium: perinuclear spaces, rough endoplasmic reticulum, Golgi completes, external surfaces and endocytic invaginations of the basolateral plasmalemma, and in membranous vesicles throughout the cytoplasm. These observations suggest that the synthesis, external expression and transcellular migration of SC occur independent of the presence of immunoglobulins. The migration of SC from the basolateral cell surfaces to apical surfaces may be an inherent property of epithelial cells and the primary event in the translocation of polymeric immunoglobulins across the cells to external body fluids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00078.x
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  • 2
    Electronic Resource
    Electronic Resource
    UVB radiation further stimulates proliferation in the already hyperproliferative epidermis of the asebia mouse (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 366-367 
    Details
    ISSN: 1432-069X
    Keywords: UVB radiation ; Hyperproliferation ; Epidermis ; Asebia mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412984
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  • 3
    Electronic Resource
    Electronic Resource
    Optimization of tetrachlorosalicylanilide and ultraviolet A doses a sensitization and challenge for contact photosensitivity in the mouse (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 351-354 
    Details
    ISSN: 1432-069X
    Keywords: Tetrachlorosalicylanilide ; Ultraviolet A ; Photosensitivity ; Dose responses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied contact photosensitivity (CPS) to tetrachlorosalicylanilide (TCSA) in BALB/cJ mice with various doses of TCSA and UVA at sensitization and challenge. From these studies we recommend the following protocol: sensitization on days 0 and 1 with 50 μl of 1% TCSA followed by 3 J/cm2 of UVA, and challenge on day 7 with 10 μl of 3% TCSA followed by 6 J/cm2 of UVA. This gave an ear swelling response of 27.4±0.6×10-3 (mean±standard error). We also demonstrated that there is reciprocity between volume and concentration of TCSA at sensitization but not between TCSA and UVA doses at sensitization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412981
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of proliferating cell nuclear antigen/cyclin in human skin (1992)
    Springer
    Archives of dermatological research 284 (1992), S. 86-91 
    Details
    ISSN: 1432-069X
    Keywords: Cyclin ; Proliferating cell nuclear antigen ; Squamous cell carcinoma ; Basal cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Expression of proliferating cell nuclear antigen/cyclin (PCNA/cyclin) in skin tissue specimens and cultured keratinocytes was studied using a monospecific antibody, obtained from a patient with systemic lupus erythematosus, and a monoclonal antibody. Indirect immunofluorescent staining revealed that cultured keratinocytes obtained from human foreskins expressed PCNA/cyclin as variable nuclear patterns in 15–30% of the cells. In normal human skin tissue specimens, PCNA/cyclin was demonstrated in only a few basal cells. Interestingly, PCNA/cyclin was expressed strongly in almost all the cells of the lowest layer of the epidermis adjacent to squamous cell carcinomas, whereas the tumor aggregates themselves had no positive staining. In contrast, no such characteristic staining was demonstrated in specimens of basal cell carcinoma. The staining pattern of PCNA/cyclin was different from that of Ki-67 in the skin tissue specimens. Our results suggest that PCNA/cyclin could be a useful marker of cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373375
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  • 5
    Electronic Resource
    Electronic Resource
    Condensed matter (1989)
    [s.l.] : Nature Publishing Group
    Nature 337 (1989), S. 314-314 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AT THE end of a eukaryotic mitosis, most of the chromatin in the cell decondenses. Some does not and remains genetically inactive — this material, with its distinctive cytological properties, is called hetero-chromatin. Until recently there has been a gap between the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/337314a0
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  • 6
    Electronic Resource
    Electronic Resource
    Immunocytochemical localization of sphingolipid activator protein-1, the sulfatide/GM1 ganglioside activator, to lysosomes in human liver and colon (1986)
    Springer
    Histochemistry and cell biology 86 (1986), S. 195-200 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sphingolipid activator proteins (SAP) stimulate the enzymatic hydrolysis of sphingolipids. The results of biochemical studies have suggested that SAP are located within lysosomes. In this study we sought immunocytochemical verification of the lysosomal location of SAP-1, a SAP that stimulates the hydrolysis of sulfatide and GM1 ganglioside. We stained adjacent sections of normal adult liver and colon for either SAP-1, by peroxidase-labeled antibodies, or acid phosphatase, by enzyme histochemistry. At the light microscopic level, SAP-1 and acid phosphatase were present in similar cells of the colonic lamina propria and hepatic sinusoids, and in similar supranuclear sites of colonic epithelial cells. By electron microscopy, SAP-1 was present in vesicular structures morphologically similar to those containing acid phosphatase. Thus, SAP-1 is present in lysosomes of several different kinds of cells in the normal human liver and colon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493387
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  • 7
    Electronic Resource
    Electronic Resource
    Macrophages in the interstitial tissue of the rat testis (1986)
    Springer
    Cell & tissue research 243 (1986), S. 337-344 
    Details
    ISSN: 1432-0878
    Keywords: Macrophages ; Leydig cells ; Testis ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Macrophages were identified in the intertubular tissue of the rat testis by loading animals with a particulate vital dye (trypan blue or India ink) and by localizing immunocytochemically a macrophage membrane antigen (MRC W3/25). Leydig cells were identified by the histochemical staining reaction for 3β-hydroxysteroid dehydrogenase activity and by a monoclonal antibody. Macrophages were scattered in the interstitial tissue closely attached to and mixed with the Leydig cells. They were never found in the seminiferous tubules. The macrophages comprised about 25% of all the cells in the interstitium. Double staining with a vital dye and a marker antibody showed that all the phagocytosing cells were macrophages and that the Leydig cells did not take up vital dyes. Double staining for the demonstration of the 3β-hydroxysteroid dehydrogenase activity and the macrophage antigen likewise revealed two distinctly different cell populations. Crude Leydig cell preparations obtained by collagenase treatment of the testis contained macrophages (12–14%). Macrophages were present throughout the postnatal prepuberal development of the testis. Their density was increased in the cryptorchid and irradiated testis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251049
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  • 8
    Electronic Resource
    Electronic Resource
    A method to enhance porosity of micro-particles (1988)
    Springer
    Journal of radioanalytical and nuclear chemistry 124 (1988), S. 523-531 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The nuclear track technique (NTT) is used to enhance the porosity of silica micro-particles. The enhanced porosity is a result of the formation of surface and interior pores or tracks in the silica by the action of external and internal fission fragments. The fission tracks produced at the surface and within the interior of the micro-particles are a result of coating the particles with trace quantitities of uranium, instead of having trace quantities of uranium incorporated within the silica matrix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02041341
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  • 9
    Electronic Resource
    Electronic Resource
    Posttranslational modification of ras proteins: Detection of a modification prior to fatty acid acylation and cloning of a gene responsible for the modification (1988)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 36 (1988), S. 261-273 
    Details
    ISSN: 0730-2312
    Keywords: Schizosaccharomyces pombe ; Saccharomyces cerevisiae ; subcellular localization ; DPR1 gene ; processing of ras protein ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Products of ras genes are synthesized as precursors in the cytosol and transported to the plasma membrane by a process which involves posttranslational modification by fatty acid. In this paper, we present evidence for the occurrence in the cytosol of an intermediate modification of ras proteins prior to the fatty acid acylation. The modification is detected by a slight shift in the mobility of the protein on SDS polyacrylamide gel. The fatty acid acylation does not contribute to this mobility shift. This modification is affected by the dpr1 mutation which has recently been shown to affect the processing of yeast RAS proteins. To further characterize the nature of the modification event, we have cloned DPR1 gene from the DNA of Saccharomyces cerevisiae. The gene is actively transcribed in yeast cells producing mRNA of approximately 1.6 kb. Genes related to the DRP1 appear to be present in a distantly related yeast, Schizosaccharomyces pombe as well as in guinea pig and human cells.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240360307
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