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  • 1
    Electronic Resource
    Electronic Resource
    Lymphoproliferative responses to Borrelia burgdorferi in circumscribed scleroderma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Humoral immune responses to Borrelia hurgdorferi (Bb) have been reported to occur in certain patients with circumscribed scleroderma (CS) (morphoea). Together with the isolation of spiro-chaetes from CS skin biopsies, this finding was taken to suggest Bb as the aetiological agent of CS. Since there is cellular immunoreactivity to Bb in patients with chronic Lyme borreliosis (LB). Bb-specific lymphocytic responses were tested in patients with CS. For this purpose, peripheral blood mononuclear cells from CS patients and. as controls, from patients with various manifestations of LB, and from healthy volunteers without any evidence of Bb infection, were exposed to Bb organisms for 5 days and then assayed for DNA synthesis. Stimulation indices (SI)〉 10 were scored positive. By performing lymphocyte proliferation tests we found: (i) that not only patients with various manifestations of LB but also a considerable percentage of seropositive (five of 13 = 38%) and seronegative (six of 26 = 23%) CS patients exhibit an elevated Bb-induced lymphocyte proliferation; (ii) that the magnitude of the cellular response seen in CS patients is comparable to that encountered in patients with established Bb manifestations; and (iii) that, within a given patient, antibiotic therapy can result in a significant reduction of this response. These results support a causative role of Bb in at least some CS patients. Bb-induced lymphocyte responses were also seen in both seropositive and seronegative erythema chronicum migrans patients. These findings show that the pattern of Bb-specific immune responses is more complex than previously thought, and underscore the importance of lymphocyte function assays in evaluating the diagnosis of potential Bb infection in seronegative patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07615.x
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  • 2
    Electronic Resource
    Electronic Resource
    Kritische Evaluation von Fructosamin als Kontrollparameter in der Beurteilung der diabetischen Stoffwechseleinstellung (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 379-385 
    Details
    ISSN: 1432-1440
    Keywords: Diabetes ; Fructosamine ; Non-enzymatic protein glycosylation ; Glycated hemoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For some years the glycosylated plasma proteins, the so-called fructosamines, have been used for the evaluation of metabolic control in diabetic patients. We studied the usefulness of fructosamine as an intermediate parameter in the control of diabetes and we also corrected fructosamine for serum protein. Furthermore, the dependence on daily times and amounts of food intake were examined for fructosamine alone as well as for protein-corrected fructosamine. Both parameters showed a statistically significant correlation with HbA1C (r=0,7;P〈0,001). Changes in the metabolic state of the diabetic patients were reflected more rapidly by both these parameters than by HbA1C. While the correction of fructosamine for serum protein eliminated its postprandial increase in the diabetic patients, circadian variation remained unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711265
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence for negative correlation between quantitative histological studies and microradiography of iliac crest bone and forearm osteodensitometry in elderly women with osteoporosis (1982)
    Springer
    Calcified tissue international 34 (1982), S. 456-458 
    Details
    ISSN: 1432-0827
    Keywords: Osteoporosis ; Histomorphometry ; Microradiography ; Osteodensitometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Quantitative histomorphometric and microradiographic analysis of iliac crest bone biopsy specimens of 10 unselected and untreated postmenopausal women with osteoporosis was performed and the results were correlated with the values measured by osteodensitometry on the right forearm. No positive correlation between histomorphometry or microradiography and osteodensitometry was observed. Moreover, the data of various histomorphometric parameters and those of the bone mineral content measured by microradiography revealed a significant negative correlation when compared to the values obtained by osteodensitometry. Our results suggest, that evaluation of one skeletal site is not necessarily representative of the entire skeleton in patients with postmenopausal osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411284
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  • 4
    Electronic Resource
    Electronic Resource
    Gefahren der Statistik am Beispiel einer Dysplasieuntersuchung (1976)
    Springer
    Archives of orthopaedic and trauma surgery 84 (1976), S. 169-177 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand von 97 zufällig ausgewählten Kindern im Alter von 5–16 Wochen werden die Winkel nach Hilgenreiner und der Einfluß verschiedener Faktoren darauf, wie etwa familiäre Anamnese und Frühgeburt, untersucht. Die gefundenen Werte werden mit den von Tönnis u. Brunken publizierten verglichen. Dabei scheinen die Werte dieser Autoren für die Normalbevölkerung zu hoch zu liegen. Auf die Notwendigkeit einer exakten Stichprobenauswahl wird hingewiesen.
    Notes: Summary In 97 cases of randomly selected children of an age from 5 to 16 weeks the angles of Hilgenreiner are determined. In relation to these findings also the influence of various factors such as hereditary anamnesis and untimely birth are observed. The so found data are compared with those published from Tönnis and Brunken. It seems that their data are higher than those in an average population. The necessity of an exact random test is pointed out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414976
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of acetyl-salicylic-acid pretreatment on re-formed aqueous humor (1980)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 214 (1980), S. 61-67 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei insgesamt 67 Patienten, die einer intracapsulären Extraktion der getrübten Augenlinse unterzogen wurden, konnte am Beginn der Operation primäres und vor dem endgültigen Wundverschluß neugebildetes „sekundäres” Kammerwasser entnommen werden. Bei 28 dieser Patienten wurde eine Vorbehandlung mit Acetyl-Salicylsäure (insgesamt 2,5 g, beginnend 18h vor der Operation) durchgeführt. Unmittelbar nach Beendigung der Operation wurde bei 55 Patienten eine Serumprobe abgenommen. In allen Proben wurden mit Hilfe der radialen Immundiffusion Albumin und IgG bestimmt. In der Gruppe der vorbehandelten Patienten fand sich ein signifikant geringerer relativer Anstieg des Proteins mit höherem Molekulargewicht (P〈0.05). Der Anstieg der Proteine zeigte jedoch keine Abhängigkeit von ihrem Serumspiegel. Die einzige beobachtete Nebenwirkung dieser Behandlung war eine signifikante Erhöhung des Serum-Albumin-Spiegels, deren Ursache unbekannt ist. Der mögliche klinische Anwendungsbereich einer Behandlung mit Prostaglandin-Synthese-Inhibitoren bei Risikopatienten wird kurz zusammengefaßt.
    Notes: Abstract Aqueous humor (a.h.) was sampled in 67 patients operated on for cataract by intracapsular lens extraction at the start and finish of surgery. Twenty eight of these patients received pretreatment with acetyl-salicylic acid (ASA), to a total of 2.5 g, beginning 18 hours prior to surgery. A serum sample was drawn immediately following the operation from 55 patients. Using radial immunodiffusion, albumin and IgG were measured in primary and secondary a.h. and in serum. The group pretreated with ASA showed a significantly smaller relative increase of IgG (P〈0.05). The increase of the proteins, however, showed no dependence on their serum-level and the only side-effect of the treatment was an unexplained rise in serum-albumin. The possible clinical application for patients with a high risk of postoperative complications is briefly summarized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414538
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  • 6
    Electronic Resource
    Electronic Resource
    Human tear lysozyme (1982)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 218 (1982), S. 265-270 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 116 Personen ohne Erkrankungen des äußeren Auges (67 Männer und 49 Frauen) wurde Trä nenflüßigkeit beider Augen mit Hilfe von Filterpapierscheibchen gewonnen. Dieser Vorgang wurde nach Applikation eines Lokalanästhetikums wiederholt. Nach dem Auswiegen und Eluieren der Tränenprobe wurde Lysozym mittels zweier immunologischer Methoden (der radialen Immundiffusion und der Immunelektrophorese) sowie einer spectrophotometrischen Technik bestimmt. Zur Erstellung der Standardkurven wurde gereinigtes menschliches, sowie Hühner-Eiweiß-Lysozym verwendet. Zusätzlich wurde Albumin mittels der Immunelektrophorese bestimmt. Die Werte aller Lysozym-Bestimmungen zeigten eine hohe Korrelation, wobei jedoch die Mittelwerte der turbidimetrischen Technik signifikant unter jenen der immunologischen Methoden lagen, wenn humanes Lysozym zur Erstellung der Standardkurve verwendet wurde.
    Notes: Abstract In 116 persons (67 men and 49 woman) the tear fluid of both eyes was collected using paper discs and once more after topical anaesthesia. After weighing the discs and eluting the tear fluid, the lysozyme content was measured using two immunological methods [radial immunodiffusion (RID) and rocket immuno-electrophoresis (RIE)] and a spectrophotometric assay. Standard curves were established with purified human lysozyme and egg-white lysozyme. In addition, albumin was determined in all the samples by rocket immuno-electrophoresis. All lysozyme assays showed a high degree of correlation, the spectrophotometric technique giving significantly lower values (compared with RID and RIE) when human lysozyme was used for standardization. The lysozyme content of the tears did not correlate with the fluid uptake in the discs, but showed a significant decrease with age, which was abolished by topical anaesthesia. In contrast, albumin levels were dependent upon the weight and independent of the age of the patient. It is suggested that the determination of albumin as a ‘reference protein’ might help in comparing the results of different tear sampling techniques used by various groups, which induce variable amounts of reflex tearing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02175895
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