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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of a 58- and a 78-kD Monocytic Membrane Protein with Affinity to the Acetylcholine Receptor in Myasthenia Gravis Patients (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 39 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The autoimmune disease myasthenia gravis (MG), caused by the effect of specific antibodies, directed towards the nicotinic acetylcholine receptor, is triggered by autoantigen-specific T cells. In order to investigate cellular parts of the immune response in MG, the authors investigated the binding of the nicotinic acetylcholine receptor (AChR) to peripheral blood mononuclear cells (PBMC) from MG patients. AChR binding cells were identified by resetting experiments using AChR-coated fluoresceine beads. Applying this technique, a significant percentage of PBMC (21.2 × 7.65%) from MG patients formed rosettes with AChR-coated beads.Membrane preparations of nycodenz- or percoll-separated monocytes from MG patients or T-cell depleted monocytic subpopulations were applied to SDS-PAGE under reducing conditions. Ligand-blotting studies with biotinylated AChRs revealed two cell-membrane proteins with molecular weights of 58- and 78-kD. In parallel the same results were obtained by affinity chromatography of monocytic membrane proteins using AChR-sepharose. A possible interference of anti-AChR IgG was excluded. The 58- and the 78-kD proteins are detectable under reducing conditions by ligand blotting with AChR-biotin, while under non-reducing conditions only the 58-kD protein can be detected. Furthermore, in experiments using Endoglycosidase-H, the 58-kD protein appears to be non-glycosylated, while the 78-kD protein bears carbohydrates.These findings suggest that monocytes which bind the AChR via specific membrane proteins on their surface might act as antigen-presenting cells and may lead to an induction of the T-cell response, in the early phase of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03376.x
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  • 2
    Electronic Resource
    Electronic Resource
    CONCANAVALIN A INDUCED SUPPRESSOR CELLS IN THE PERIPHERAL BLOOD OF MY ASTHENIA GRAVIS PATIENTS (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 377 (1981), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1981.tb33793.x
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  • 3
    Electronic Resource
    Electronic Resource
    Peripheral Blood Mononuclear Cells in Myasthenia Gravis Patients Specifically Binding Acetylcholine Receptor Beads (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 505 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb51341.x
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  • 4
    Electronic Resource
    Electronic Resource
    Thoracic Computer Tomography for Thymus Diagnosis in Myasthenia Gravis (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 505 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb51403.x
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  • 5
    Electronic Resource
    Electronic Resource
    Heterogenität von Acetylcholinrezeptor-Antikörpern bei Myasthenia gravis Patienten (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 377-385 
    Details
    ISSN: 1432-1440
    Keywords: Myasthenia gravis ; Acetylcholine receptor antibody ; Antibody heterogeneity ; Cross-reactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies against the nicotinic acetylcholine receptor in sera of 21 myasthenia gravis patients were checked for their ability to block or split binding of α-bungarotoxin to the human acetylcholine receptor. Affinity-purified acetylcholine receptors from human skeletal muscle were used in parallel in the common precipitation assay and an inhibition assay. Cross-reactivity of acetylcholine receptor antibodies was analyzed with receptor preparation from different species (calf, rat,Torpedo c. andElectrophorus e.), purified identically to high specific activity. An antibody pattern was set up for each patient and related to the clinical state of the disease. α-Bungarotoxin-inhibiting antibodies were demonstrable in 74% of myasthenia gravis patients, α-bgt displacing antibodies were found in 39% of the investigated sera. Broad cross-reactivity with acetylcholine receptors from other mammalian muscle was evident (calf 75%, rat 90%) only very few sera reacted with acetylcholine receptors from electric fish (Torpedo c. 14%,Electrophorus e. 38%). Antibody concentrations determined by using xenoantigens were much lower than those obtained by human acetylcholine receptor. The lack of a clear-cut correlation between the amount of serum antibodies and the clinical state of myasthenia gravis can be explained by the established antibody-heterogeneity, shown by a constant antibody pattern characteristic for each patient. However, between this specific antibody pattern and the state of the disease no correlation could be established either.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716258
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  • 6
    Electronic Resource
    Electronic Resource
    Grand-mal-Serie nach Ecstasy-Einnahme (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 1094-1097 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Grand-mal-Serie ; Ecstasy-Intoxikation ; MDMA-Liquorkonzentration ; Key words Series of grand mal seizures ; Ecstasy intoxication ; MDMA Level in CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The consumption of the jet set drug Ecstasy (3,4-methylenedioxymetamphetamine, abbreviated to MDMA) by young people is increasing markedly. Parallel to this developement, there is a large number of reports on severe neurological, psychiatric and medical complications following the use of Ecstasy. Seizures are among the most common clinical complications of the CNS following the ingestion of Ecstasy. Our report presents the case of a 21-year-old patient, who had a series of grand mal seizures after taking 12 tablets of Ecstasy. 36 hours after ingestion the substance MDMA was demonstrated at a level of 300 ng/ml in the serum and CSF. Following treatment with Clonazepam and under an adequate level of carbamazepine, no further seizures occurred. The diagnosis was difficult because the patient initially denied the consumption of drugs and the routine toxicological screening does not contain the substance MDMA.
    Notes: Zusammenfassung Der Konsum der Modedroge Ecstasy (3,4-methylendioxymetamphetamin, kurz MDMA) nimmt bei Jugendlichen stark zu. Parallel dazu häufen sich Berichte über schwere neurologische, psychiatrische und internistische Komplikationen nach Gebrauch von Ecstasy. Zerebrale Krampfanfälle gehören zu den in der Literatur am häufigsten geschilderten Krankheitsbildern des ZNS nach Ecstasyeinnahme. Wir berichten über einen 21 Jahre alten Patienten, der nach Konsum von 12 Tabletten Ecstasy eine Grand-mal-Serie erlitt. Die Substanz MDMA konnte in ca. 36 h nach Einnahme gewonnenen Serum- und Liquorproben in identischer Konzentration von 300 ng/ml nachgewiesen werden. Unter Clonazepam-Gabe und Aufsättigung mit Carbamazepin traten keine weiteren zerebralen Krampfanfälle mehr auf. Erschwert wurde die Diagnosestellung einer Ecstasy-Intoxikation dadurch, daß der Patient einen Drogenkonsum zunächst verneinte und das durchgeführten Routinetoxikologiescreening die Substanz MDMA nicht beinhaltete.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050544
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  • 7
    Electronic Resource
    Electronic Resource
    Air fluidization therapy of pressure sores due to Guillain-Barré and Cushing syndrome (1992)
    Springer
    Intensive care medicine 18 (1992), S. 62-63 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01706436
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  • 8
    Electronic Resource
    Electronic Resource
    Continuous multivariable monitoring in neurological intensive care patients-preliminary reports on four cases (1991)
    Springer
    Intensive care medicine 17 (1991), S. 87-93 
    Details
    ISSN: 1432-1238
    Keywords: Continuous multivariable monitoring ; Multimodality evoked potentials ; Brain death ; Coma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Evoked potential monitoring is a standard examination method in neurological intensive therapy units. Previously, multimodality observation was only possible in follow-up examinations. First experience with a new bed-side system continuously monitoring 12 neurophysiological and clinical parameters is reported. It consists of a personal computer and various stimulation units. EEG activity, median nerve somatosensory evoked potentials (SEPs) and brainstem auditory evoked potentials (BAEPs) are recorded. Additionally, EEG spectral band power, heart rate, heart rate variability, intracranial presure, body temperature, expiratory PCO2, blood pressure and transcutaneously measured oxygenation can be monitored. This paper reports on 4 exemplary cases of the 33 patients we have monitored to date, illustrating the principles and main advantages of the system. The system was developed to support the observation of ICU patients as well as to aid therapeutic decisions. It supports the clinical determination of brain death by specifying the deterioration of various neurological systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01691429
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  • 9
    Electronic Resource
    Electronic Resource
    Cross-sectional epidemiological study on neurotoxicity of solvents in paints and lacquers (1988)
    Springer
    International archives of occupational and environmental health 60 (1988), S. 233-241 
    Details
    ISSN: 1432-1246
    Keywords: Neurotoxicity ; Organic solvents ; Painters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a multi-disciplinary retrospective study we examined 105 house painters employed for at least ten years (median 27 years, range 10–36 years). Fifty-three workers from various professions (non-painters), who were matched with regard to age, occupational training and socio-economic status served as the control group. In both groups no cases of a clinically manifest polyneuropathy or encephalopathy were found. The neurophysiological examinations (EEG and NCV-measurement) showed no differences in painters and controls that would indicate adverse effects of organic solvents. There were no cases with neuroradiological findings of a diffuse cerebral atrophy. Furthermore the evaluation of certain brain structures (ventricular diameter, cella media index) of the CAT films did not reveal any significant differences. In the neurobehavioral tests significant differences in the results were only found in the subtests “change of personality” and “short term memory capacity” in a subgroup of painters with repeated prenarcotic symptoms at the workplace. Ambient air monitoring measurements at 30 representative work-places showed that the concentrations of the main components of the solvent-mixtures were well below the MAK-values. The results of the “Erlangen Painter Study” does not confirm former epidemiologic findings from other countries, mainly Denmark. However, there are some aspects, such as minor solvent exposure in German house painters, insufficient diagnostic and etiological procedures as well as mis-classifications which may explain the different experiences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378470
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  • 10
    Electronic Resource
    Electronic Resource
    Fatal complications after myelography with meglumine diatrizoate (1990)
    Springer
    Neuroradiology 32 (1990), S. 70-73 
    Details
    ISSN: 1432-1920
    Keywords: Intrathecal diatrizoate meglumine ; Lethal dysregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593948
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