ISSN:
1432-0614
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary A model, suitable for reactor-design purposes, is presented for the infection process of insect cells with baculovirus in a continuous bioreactor system. The infection process can be described by a first-order reaction mechanism if the viable, non-infected, insect cells are regarded as substrate, and the resulting polyhedra as product. Experimental results from continuous systems, consisting of a series of mixed reactors in which growth of Spodoptera frugiperda cells takes place in the first reactor and infection with Autographa californica nuclear polyhedrosis virus in the other reactors in the series, show typical values for the reaction rate constant of 0.7–1.0 10-5 s-1.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00263855
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