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  • 1
    Electronic Resource
    Electronic Resource
    Oxygen transfer in a multiple air-lift loop reactor (1995)
    Springer
    Bioprocess and biosystems engineering 12 (1995), S. 167-172 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The Multiple Air-lift Loop reactor (MAL) is a new type of bioreactor, in which a series of airlifts with internal loops is incorporated into one vessel. As such, the MAL is an approximation of an aerated plug-flow fermenter. Gas/liquid oxygen transfer was studied as a function of the gas flow rate in a MAL. The second MAL-compartment in the series was investigated in particular, and a Rectangular Air-lift Loop reactor (RAL) was used as a reference. Both a dynamic and a steady-state method were used for the determination of the overall volumetric oxygen-transfer coefficient. Both methods gave the same results. The oxygen transfer coefficient in the second MAL-compartment was low compared to that of conventional internal-loop reactors. Wall effects probably caused bubble coalescence and a reduction in the oxygen transfer. For the RAL it was found that oxygen transfer was comparable to that in a bubble column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01767462
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Production of Baculovirus or Recombinant Derivatives in Continuous Insect-Cell Bioreactors (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 613 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb18159.x
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  • 3
    Electronic Resource
    Electronic Resource
    Production of Baculovirus in a Continuous Insect-Cell Culture (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 589 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb24261.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Oxygen transfer in a multiple air-lift loop reactor (1995)
    Springer
    Bioprocess engineering 12 (1995), S. 167-172 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  The Multiple Air-lift Loop reactor (MAL) is a new type of bioreactor, in which a series of airlifts with internal loops is incorporated into one vessel. As such, the MAL is an approximation of an aerated plug-flow fermentor. Gas/liquid oxygen transfer was studied as a function of the gas flow rate in a MAL. The second MAL-compartment in the series was investigated in particular, and a Rectangular Air-lift Loop reactor (RAL) was used as a reference. Both a dynamic and a steady-state method were used for the determination of the overall volumetric oxygen-transfer coefficient. Both methods gave the same results. The oxygen transfer coefficient in the second MAL-compartment was low compared to that of conventional internal-loop reactors. Wall effects probably caused bubble coalescence and a reduction in the oxygen transfer. For the RAL it was found that oxygen transfer was comparable to that in a bubble column. List of symbols A d [m2] cross-sectional downcomer area A r [m2] cross-sectional riser area a [m2 ⋅ m-3] specific gas/liquid interfacial surface area c l [mol ⋅ m-3] actual oxygen concentration in the liquid c s [mol ⋅ m-3] saturation oxygen concentration d b [m] mean bubble diameter H w [m] separator-wall height H l [m] liquid height above reactor base k ol [m ⋅ s-1] overall oxygen transfer coefficient R 2 [m] inner radius for the separator wall in the second MAL compartment T [°C] temperature t [s] time ν gs [m ⋅ s-1] superficial gas velocity w [m] separator-wall thickness α [–] overall gas holdup ρ [kg ⋅ m-3] density τ m [s] mixing time Φ l [m3 ⋅ s-1] liquid flow rate Subscripts d de-oxygenation vessel in incoming out outcoming r reactor
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01767462
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of optimization methods for fed-batch cultures of hybridoma cells (1997)
    Springer
    Bioprocess engineering 17 (1997), S. 99-102 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Two methods for the calculation of optimal trajectories for the input variables of a fed-batch culture of hybridoma cells are compared. It pointed out that a gradient method based on Pontryagins' minimum principle based yields a significant better performance with respect to computational effort and the calculated minimum than a dynamic programming approach which has been presented in a previous paper [1] as the most suitable method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050360
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Optimum design for a series of continuous stirred tank reactors containing immobilized biocatalyst beads obeying intrinsic Michaelis-Menten kinetics (1989)
    Springer
    Bioprocess and biosystems engineering 4 (1989), S. 153-158 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The optimum design of a series of mixed reactors containing immobilized biocatalysts is described. A detailed description is given of the modelling of internal diffusion and reaction in the beads, and external mass transfer resistance. The model is validated by experiments with cascades of two and three reactors, containing immobilized invertase. For that, invertase was first bound to DE32-cellulose anion exchanger and then entrapped in Calcium Alginate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369393
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of initial biomass concentration on the growth of immobilized Nitrosomonas europaea (1994)
    Springer
    Applied microbiology and biotechnology 42 (1994), S. 153-157 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Nitrosomonas europaea was immobilized in carrageenan-gel beads with a low and a high biomass concentration (100-fold difference). Under growth conditions in a continuous air-lift loop reactor, a low initial concentration yielded a few large micro-colonies per bead, whereas a high initial biomass concentration resulted in many small micro-colonies per bead. The macroscopic consumption rate of the latter was three times higher under the circumstances applied. This is also predicted by our colony-expansion model when diffusion limitation over the micro-colonies is incorporated. This model also predicts that diffusion limitation over the ultimate colonies is negligible when the initial biomass concentration exceeds 0.5 kg·m−3 of carrageenan gel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170239
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  • 8
    Electronic Resource
    Electronic Resource
    Continuous production of baculovirus in a cascade of insect-cell reactors (1990)
    Springer
    Applied microbiology and biotechnology 33 (1990), S. 43-47 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Insect cells (Spodoptera frugiperda) were cultured in a continuous stirred-tank reactor. The effluent was led to a cascade of another two reactors, each containing half the volume of the cell-growth reactor, where the cells were infected with Autographa californica nuclear polyhedrosis virus. For about 10 days production of 107 polyhedra (virus particles embedded in a protein capsule) per cm3 was achieved. This short production time compared to previous experiments involving an analogous system with a single infection vessel of equal volume to the cell-growth vessel is ascribed to the accelerated occurence of the so-called passage effect (a decrease of infectious virus with time). From the results of a computer model it was concluded that this passage effect was accelerated by the change in residence time distribution as compared to the earlier experiments. time distribution as compared to the earlier experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170567
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  • 9
    Electronic Resource
    Electronic Resource
    Erratum (1989)
    Springer
    Applied microbiology and biotechnology 31 (1989), S. 434-434 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257618
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  • 10
    Electronic Resource
    Electronic Resource
    A model for baculovirus production with continuous insect cell cultures (1989)
    Springer
    Applied microbiology and biotechnology 30 (1989), S. 497-501 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A model, suitable for reactor-design purposes, is presented for the infection process of insect cells with baculovirus in a continuous bioreactor system. The infection process can be described by a first-order reaction mechanism if the viable, non-infected, insect cells are regarded as substrate, and the resulting polyhedra as product. Experimental results from continuous systems, consisting of a series of mixed reactors in which growth of Spodoptera frugiperda cells takes place in the first reactor and infection with Autographa californica nuclear polyhedrosis virus in the other reactors in the series, show typical values for the reaction rate constant of 0.7–1.0 10-5 s-1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263855
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