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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 28 (2003), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 66-year-old male, whose primary skin lesion in extramammary Paget's disease had been surgically resected 4 years previously, was hospitalized with liver metastases. Hepatic arterial infusion chemotherapy was carried out and the tumours clearly reduced in size. Serum levels of some common tumour markers were not elevated, even prior to therapy. We measured serum levels of a novel tumour-associated antigen, RCAS1, because its expression was detected in the tumour cells. The patient's serum RCAS1 level was elevated (22.0 U/mL) before therapy and fell during (10.5 U/mL) and after (5.0 U/mL) therapy. Therefore, serum RCAS1 levels may be valuable as a potential biomarker for monitoring therapeutic efficacy against Paget's disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    The @island arc 12 (2003), S. 0 
    ISSN: 1440-1738
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Abstract  Pressure and temperature (P–T) conditions of mélange formation are estimated from fluid inclusions within “syn-mélange” veins developed in the necks of boudins of sandstone blocks in the mélange of the Shimanto accretionary complex, south-west Japan. The mélange records décollement-zone processes. P–T conditions are in the range of 81 (+15) to 235 (±18) MPa and 150 (±25) to 220 (±31)°C. Assuming a constant fluid-pressure to lithostatic-pressure ratio for each data set, we estimate a P–T gradient of between 10.0°C/km (+0.2/−1.5) (lithostatic pressure) and 4.2°C/km (+0.1/−0.9) (hydrostatic pressure) from these results. The estimated lithostatic P–T gradient is much lower than that calculated from the age of the subducting oceanic plate. The estimated P–T conditions suggest that the mélange was formed within the seismogenic zone (hypothesized from thermal modeling), although the deformation mechanism of mélange (i.e. dominant diffusive mass transfer mainly in shale matrix with minor brittle breakage mainly in sandstone blocks) does not show evidence of seismic deformation. In addition, at the time of syn-mélange vein formation, a shale matrix of mélange has injected into the vein, which indicates a ductile deformation of shale. A possible explanation for this discrepancy is that the mélange was formed during the interseismic period.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 21 (1992), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A mapping study of cystectomy specimens in three cases of pure squamous cell carcinoma and 28 cases with transitional cell carcinoma with squamous differentiation is described, with an emphasis on the histogenesis of pure squamous cell carcinoma. Two of the three cases of pure squamous cell carcinoma had extensive benign keratinizing mucosa and an atypical squamous metaplastic mucosa contiguous with the tumour. These pure squamous cell carcinomas seemed to be derived from the squamous metaplasia. On the other hand, in all except one of the cases of transitional cell carcinoma with squamous differentiation, there was neither benign keratinizing nor atypical squamous metaplastic mucosa in the bladder.The quantitative amounts of both the transitional cell and squamous components differed from case to case in 28 cases with transitional cell carcinoma with squamous differentiation. Five of the 28 had a tumour composed predominantly of a squamous component with minute transitional cell components at the margin. In another two cases, transitional carcinoma in situ or satellite tumours of transitional cells were present adjacent to the main tumour which was composed of squamous cell carcinoma alone. We think these seven tumours originated as a result of extensive squamous differentiation in the transitional cell carcinomas. These features may indicate two forms of histogenesis of pure squamous cell carcinoma. The first is malignant transformation on the basis of squamous metaplasia of the bladder mucosa and the second is extensive squamous differentiation in a pre-existing transitional cell carcinoma.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1076
    Keywords: Xanthogranuloma ; Cholecystitis ; Jaundice ; Infants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a female infant with obstructive jaundice due to inflammatory stenosis of the choledochus. It was surrounded and narrowed by a xanthogranulomatous lesion, extending from xanthogranulomatous cholecystitis (XGC). The obstructive jaundice was released by a cholecysiectomy, resection of the choledochus, and hepaticojejunostomy. This is the first reported case of infantile XGC associated with obstructive jaundice.
    Type of Medium: Electronic Resource
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